Clinical approach to donor‐derived infection in solid organ transplant recipients DOI
Varun K. Phadke

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(S1)

Published: July 16, 2024

Donor-derived infection is an uncommon but potentially devastating complication of solid organ transplantation (SOT). Accurate and timely identification unexpected infectious disease transmission events has implications not only for the recipient(s) experiencing infection, also other recipients organs or tissues from same donor who may require additional testing risk mitigation, as well broader transplant regulatory framework. This narrative review synthesizes data published reports symptomatic donor-derived infections in SOT to provide clinicians with a systematic approach evaluation undifferentiated illnesses that be origin. Key reasons consider include certain microbiologically proven recipient, especially early after transplant, characteristics their management suggest potential exposure specific pathogens prior procurement, select clinical syndromes occur post-transplant period. Syndromes which expedited consideration warranted central nervous system graft perigraft complications developing absence typical factors, unexplained critical illness/sepsis syndrome When embarking on investigation suspected should apply knowledge entire continuum procurement process ensure unbiased comprehensive collection will facilitate appropriate adjudication these high-consequence events.

Language: Английский

Child Organ Offer Process (cOOPS): Understanding Infectious Risk Assessment and Mitigation Strategies DOI
Taekhee Lee, Katya Prakash, Hannah Bahakel

et al.

Pediatric Transplantation, Journal Year: 2025, Volume and Issue: 29(4)

Published: May 7, 2025

ABSTRACT Introduction Pediatric Infectious Disease (PID) clinicians involved in solid organ transplantation often assess infection risk and mitigation strategies for donor offers. While some guidance is available, real‐life practice patterns have not been previously described. Methods We surveyed PID about acceptance associated posttransplantation interventions using 12 fictitious pediatric case scenarios through 3 PID‐specific listservs. Descriptive statistics were employed. Results 48 (71.6%) of 67 ID respondents offer assessment. Agreement was strong (> 80%) to accept (syphilis, severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2], MRSA, E. coli , TB [liver], rhino/enterovirus) or decline (undifferentiated encephalitis, [lung]) organs from these cases, while there less agreement cases with coccidioidomycosis, Chagas disease, multi‐drug‐resistant Acinetobacter baumannii influenza. Less present posttransplant monitoring antimicrobial administration. Practice varied testing treatment donors SARS‐CoV‐2 positive test, MRSA bacteremia, disease. Conclusions For many scenarios, high; however, improved education based on currently available recommendations may enhance decision‐making. The variability management highlights educational research opportunities optimize limit the impact donor‐derived infections recipients.

Language: Английский

Citations

0
Clinical approach to donor‐derived infection in solid organ transplant recipients DOI
Varun K. Phadke

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(S1)

Published: July 16, 2024

Donor-derived infection is an uncommon but potentially devastating complication of solid organ transplantation (SOT). Accurate and timely identification unexpected infectious disease transmission events has implications not only for the recipient(s) experiencing infection, also other recipients organs or tissues from same donor who may require additional testing risk mitigation, as well broader transplant regulatory framework. This narrative review synthesizes data published reports symptomatic donor-derived infections in SOT to provide clinicians with a systematic approach evaluation undifferentiated illnesses that be origin. Key reasons consider include certain microbiologically proven recipient, especially early after transplant, characteristics their management suggest potential exposure specific pathogens prior procurement, select clinical syndromes occur post-transplant period. Syndromes which expedited consideration warranted central nervous system graft perigraft complications developing absence typical factors, unexplained critical illness/sepsis syndrome When embarking on investigation suspected should apply knowledge entire continuum procurement process ensure unbiased comprehensive collection will facilitate appropriate adjudication these high-consequence events.

Language: Английский

Citations

1