Improving the Biostability of Extra Virgin Olive Oil with Olive Fruit Extract During Prolonged Deep Frying

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 260 - 260

Published: Jan. 15, 2025

This study explores approaches to enhancing the biostability of extra virgin olive oil (EVOO) supplemented with fruit extract (OFE) enriched hydroxytyrosol (HTyr). The investigation focuses on prolonged deep frying (DF) conditions at 170 °C and 210 °C, over durations ranging from 3 48 h, aim improving sensorial attributes, polyphenolic content, thermal oxidative stability. Parameters, such as acidity, peroxide value (PV), K232, K270, ΔK, phenolic compounds, sensory were monitored. PV did not exceed standard limit in HTyr-EVOO °C/24 h; however, non-supplemented EVOOs, it remained within limits only up °C/18 h. Acidity stayed acceptable (≤0.8) h both non-enriched EVOOs. K232 values ≤2.5 fried K270 ΔK °C/3 whereas they surpassed them oils. Additionally, HTyr tyrosol levels significantly higher (p < 0.05) HTyr-EVOOs. Phenolic including verbascoside, pinoresinol, 1-acetoxypinoresinol, acids, chlorogenic, vanillic, homovanillic, 4-dihydroxybenzoic, caffeic detected Oxidized secoiridoid derivatives increased DF progressed. Moreover, analysis revealed that positive attributes EVOOs—such fruity, bitter, pungent notes—decreased increasing temperature duration 0.05). Beyond °C/6 these rated zero. However, HTyr-EVOOs exhibited lower rancidity compared oils under identical conditions, attributed protective effect HTyr. In conclusion, demonstrated stability retaining desirable qualities, reduced degradation. These findings indicate natural OFEs have strong potential food additive properties, health benefits, overall innovation provides a practical solution for industry by versatility EVOO. Further research is recommended investigate various EVOO categories diverse origins.

Language: Английский

Collagen–Chitosan Composites Enhanced with Hydroxytyrosol for Prospective Wound Healing Uses

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 618 - 618

Published: May 6, 2025

Background/Objectives: Recent studies highlight the excellent wound-healing properties of collagen and chitosan materials. Combining these polymers with a bioactive compound could enhance their effectiveness as next-generation wound dressings. Hydroxytyrosol (HT), an antioxidant derived from olive oil, may aid healing due to its anti-inflammatory, antimicrobial, angiogenesis-stimulating properties, making it beneficial addition collagen–chitosan It be dressings, thus improving therapeutic effects. This study screens potential composites HT for applications assesses influence compound’s incorporation on materials’ properties. Methods: The material production involved incorporating into marine extract. resulting collagen–chitosan–HT was obtained through freeze-drying. Prototype dressing characterization included morphology by scanning electron microscopy, solid hydrated state textural rheological studies, in vitro release studies. cytocompatibility screening assessed using mouse fibroblast cell line, antibacterial activity evaluated against microorganisms commonly implicated infections. Results: Burst strength, viscosity, frequency sweep test, tackiness, adhesion results indicate that contributes material’s mechanical robustness maintaining high viscosity preserving gel structure. suggest HT-controlled profile maximum (70%) achieved after 10 h. Biological experiments confirmed skin cells very promising efficacy Staphylococcus aureus Pseudomonas aeruginosa. Conclusions: In conclusion, successfully incorporated matrix, enhancing prospect resultant material. composite presents advanced

Language: Английский

Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12844 - 12844

Published: Nov. 29, 2024

Acute liver injury (ALI) is an to tissue caused by viruses, drugs, alcohol, and oxygen deprivation, one of the most common serious clinical disorders. Hydroxytyrosol (HT) a naturally occurring polyphenolic compound isolated from forsythia has excellent anti-inflammatory properties. However, effect mechanisms HT in ALI remain unclear. We used LPS/D-GalN induced experimental mouse model AML12 cells reveal efficacy potential ALI, HE staining was for evaluation pathologies. A biochemical assay detect changes function, RNA-seq conducted underlying WB, RT-qPCR, IF were assess effects action. Furthermore, vitro against protection mechanism. significant alleviated LPS/D-GalN-induced mice suppressing inflammatory. In terms RNA-seq, improved TNF, ECM-receptor interaction, PI3K/AKT signaling pathway, it downregulated mRNA levels VCAM-1, CXCL5, TNF-α IL-6 liver. Mechanically, targeting TNF-α, thereby inhibiting TNF-α/PI3K/AKT pathway.

Language: Английский