Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds DOI
Chenguang Liu,

Li He

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

Photobiomodulation studies on diabetic wound healing: An insight into the inflammatory pathway in diabetic wound healing DOI Creative Commons

Tintswalo Nomsa Mgwenya,

Heidi Abrahamse, Nicolette N. Houreld

et al.

Wound Repair and Regeneration, Journal Year: 2024, Volume and Issue: 33(1)

Published: Nov. 28, 2024

Diabetes mellitus remains a global challenge to public health as it results in non-healing chronic ulcers of the lower limb. These wounds are challenging heal, and despite different treatments available improve healing, there is still high rate failure relapse, often necessitating amputation. Chronic diabetic do not follow an orderly progression through wound healing process associated with persistent inflammatory state characterised by accumulation pro-inflammatory macrophages, cytokines proteases. Photobiomodulation has been successfully utilised involves illuminating at specific wavelengths using predominantly light-emitting diodes or lasers. induces diminishing inflammation oxidative stress, among others. Research into application photobiomodulation for current ongoing drawn attention many researchers healthcare sector. This review focuses on pathway influence this wavelengths.

Language: Английский

Citations

5
The role of Latin America medicinal plants in wound healing DOI Creative Commons
Mariana Sánchez‒Ramos,

Andrea Ruiz-Betancourt,

Stephany Abigail Tadeo-Cuenca

et al.

Frontiers in Chemical Engineering, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 13, 2025

Wound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At biological level, wound involves complex mechanism in immune system cellular biochemical cascades intervene coordinated manner, whose development occurs stages inflammation, proliferation, remodeling. Therefore, therapies have been developed to accelerate proven effective. However, factors diabetes mellitus limit process because causes alterations microvascular dysfunction, well inflammatory response greater oxidative stress. This reflected abnormal process; therefore, search compounds has become area interest. In this regard, medicinal plants used centuries treat wounds different cultures world. Hence, review documents main plant species Latin America due its great biodiversity numerous that are potentially important new active compounds. review, 62 families with studies were found, highlighting Fabaceae, Asteraceae Euphorbiaceae family. Additionally, 32 natural diverse structural nature effects evaluated vivo vitro models, essential studying pathogenesis tissue repair mechanism, detecting biomarkers, evaluate treatments. Currently, several models study process, including silico , vitro, models. On other hand, there no appropriate model determine effect, and, many cases, they combined provide sufficient scientific evidence. demonstrates potential region research into sources molecules. Nevertheless, still being studied findings allow generating viable alternatives solution problems associated healing.

Language: Английский

Citations

0
Photobiomodulation therapy DOI Creative Commons
Praveen Arany

JADA Foundational Science, Journal Year: 2025, Volume and Issue: 4, P. 100045 - 100045

Published: Jan. 1, 2025

Language: Английский

Citations

0
Injectable dual-network hydrogel for phototherapy and immunomodulation in the treatment of MRSA-infected and diabetic wound DOI

Shengfei Bao,

Aodi Jiang,

Peng Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163026 - 163026

Published: April 1, 2025

Language: Английский

Citations

0
Therapeutic Potential of Near-Infrared Polychromatic Light in Hyperglycemic Human Cell Models: Toward Improved Diabetic Wound Healing DOI

Simge Çıtak,

Tülay Selin Erkut,

Anıl Sera Çakmak

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds DOI
Chenguang Liu,

Li He

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

Citations

0