Cerebrovascular responses to exercise DOI
Ali M. McManus, Christine M. Tallon

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 91 - 102

Published: Aug. 1, 2023

Abstract Various studies have linked exercise to brain structure and function, but the mechanistic pathways underlying exercise-induced benefits are poorly understood. Augmented function is related cerebrovascular responses in adults; however, evidence children limited. This an emerging area of integrative paediatric physiology this chapter provides insight into development cerebral metabolism blood flow, key mechanisms that regulate flow at rest, exercise. Similar adults, response incremental exhaustion adolescents biphasic, increasing up ventilatory threshold, then declining back resting values from respiratory compensation point maximum. In contrast, amplitude increase velocity about half noted adults. Unlike biphasic not mirrored by end-tidal carbon dioxide partial pressure (PETCO2), flow–ventilation relationship differs, suggesting regulatory developmentally distinct. The paucity on acute chronic physical activity training child or adolescent means true impact future health has yet be fully

Language: Английский

Atrial fibrillation, hypertension, and the cerebral vasodilatory reserve DOI Creative Commons
Takayuki Katayama,

Kae Takahashi,

Osamu Yahara

et al.

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(9), P. 2586 - 2588

Published: June 19, 2024

Schematic representation for the cascade model of atrial fibrillation, hypertension, cerebral vasodilatory reserve, and cognitive decline.

Language: Английский

Citations

0
The influence of different arterial carbon dioxide levels on the cerebrovascular autoregulation curve in a porcine cranial window model. DOI Creative Commons
Sofie Dietvorst, Bavo Kempen,

Veerle De Sloovere

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract Introduction: Cerebrovascular autoregulation (CA) is the ability to maintain adequate cerebral blood flow (CBF) over a wide range of arterial pressure (ABP). Carbon dioxide (PaCO₂) potent vasodilator, but its precise influence on CA remains incompletely understood. Methods: A porcine cranial window model, in which CBF can be measured directly pial arterioles while ABP mechanically manipulated, used investigate effect PaCO₂ capacity. Hypercapnia and hypocapnia were induced 12 male piglets each by adjusting respiratory rate. Once stable levels resp 60 mmHg 25 respectively achieved, was gradually increased half animals or decreased other beyond limits inflating balloon aorta inferior caval vein. Results: Before manipulation, hypercapnia already significant vasodilation (+33.9%) increase (+20.5%) whereas did not alter diameter CBF. Both hyper- significantly reduced adjust arteriolar diameters response changes ABP. Conclusion: During hypo- as well hypercapnia, narrowing with shorter plateau between upper lower limit observed, compared normocapnia.

Language: Английский

Citations

0
Ventilatory response to head‐down‐tilt in healthy human subjects DOI Creative Commons
Abdulaziz Alsharifi,

N Carter,

Akbar Irampaye

et al.

Experimental Physiology, Journal Year: 2024, Volume and Issue: 109(12), P. 2134 - 2146

Published: Oct. 24, 2024

Abstract Postural fluid shifts may directly affect respiratory control via a complex interaction of baro‐ and chemo‐reflexes, cerebral blood flow. Few data exist concerning the steady state ventilatory responses during head‐down tilt. We examined cardiorespiratory acute 50° tilt (HDT) in 18 healthy subjects (mean [SD] age 27 [10] years). Protocol 1 ( n = 8, two female) was HDT from 60° head‐up posture sustained for 10 min, while exposed to normoxia, normoxic hypercapnia (5% CO 2 ), hypoxia (12% inspired O ) or hyperoxic (95% , 5% ). 10, four supine, breathing either medical air hypercapnic gas. Ventilation (, pneumotachograph), end‐tidal concentration pressure (Finapres) were measured continuously throughout each protocol. Middle artery flow velocity (MCAv; transcranial Doppler) also protocol 2. increased significantly P < 0.05) compared baseline both (protocol by mean 139 [26]%) 131 [21]% 129 [23]%), despite no change baseline. No observed with hypoxia, there significant MCAv The absence leads us postulate that augmented response steep involve mechanisms related venous outflow.

Language: Английский

Citations

0
Effects of Selective Sleep Deprivation on Related Indexes of Sleep Respiratory Events in Healthy Volunteers DOI

聪 王

Advances in Clinical Medicine, Journal Year: 2022, Volume and Issue: 12(12), P. 11649 - 11656

Published: Jan. 1, 2022

Language: Английский

Citations

2
Cerebrovascular responses to exercise DOI
Ali M. McManus, Christine M. Tallon

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 91 - 102

Published: Aug. 1, 2023

Abstract Various studies have linked exercise to brain structure and function, but the mechanistic pathways underlying exercise-induced benefits are poorly understood. Augmented function is related cerebrovascular responses in adults; however, evidence children limited. This an emerging area of integrative paediatric physiology this chapter provides insight into development cerebral metabolism blood flow, key mechanisms that regulate flow at rest, exercise. Similar adults, response incremental exhaustion adolescents biphasic, increasing up ventilatory threshold, then declining back resting values from respiratory compensation point maximum. In contrast, amplitude increase velocity about half noted adults. Unlike biphasic not mirrored by end-tidal carbon dioxide partial pressure (PETCO2), flow–ventilation relationship differs, suggesting regulatory developmentally distinct. The paucity on acute chronic physical activity training child or adolescent means true impact future health has yet be fully

Language: Английский

Citations

0