Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology, Journal Year: 2024, Volume and Issue: 109(9), P. 1545 - 1556

Published: July 9, 2024

Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition enteric nervous system, using GCaMP6f reporter neural crest cell derivatives. We found spontaneous calcium activity is tetrodotoxin (TTX) resistant at stage E11.5, but not E18.5. Motility E18.5 was characterized by periodic, alternating high- and low-frequency contractions of circular smooth muscle; frequency modulation inhibited TTX. Calcium imaging neurogenic-motility stages E18.5-P3 showed Ca

Language: Английский

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Enteric neuronal substrates underlying spontaneous and evoked neurogenic contractions in mouse colon

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101462 - 101462

Published: Jan. 1, 2025

Using cell-specific tools to image myenteric neurons of mouse colon, we find that distinct subtypes are active during spontaneous neurogenic contractions.The same were evoked contractions, suggesting the existence a common contractile neuronal substrate.

Language: Английский

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Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 7, 2024

Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca

Language: Английский

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Gastrointestinal tract

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 179 - 193

Published: Dec. 4, 2024

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