Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms

International Journal of Sports Medicine, Journal Year: 2022, Volume and Issue: 44(03), P. 177 - 183

Published: Dec. 1, 2022

Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and lower in normobaric hypobaric hypoxia compared to normoxia. The aim this study was assess the effects hypobaria on BRS normoxia hypoxia. Continuous blood pressure ventilation were recorded eighteen seated participants (NNx), (HNx), (NHx) (HHx). Barometric matched between NNx vs. NHx (723±4 mmHg) HNx HHx (406±4 403±5 mmHg). Inspired oxygen (PiO

Language: Английский

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Hypoxia-Induced Pulmonary Injury—Adrenergic Blockade Attenuates Nitrosative Stress, and Proinflammatory Cytokines but Not Pulmonary Edema

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(7), P. 195 - 195

Published: June 27, 2024

Hypoxia can induce pulmonary edema (PE) and inflammation. Furthermore, hypoxia depresses left ventricular (LV) inotropy despite sympathetic activation. To study the role of hypoxic activation, we investigated effects with without adrenergic blockade (AB) on cardiovascular dysfunction lung injury, i.e., edema, congestion, inflammation, nitrosative stress. Eighty-six female rats were exposed for 72 h to normoxia or normobaric received infusions NaCl, prazosin, propranolol, prazosin-propranolol combination. We evaluated hemodynamic function performed histological immunohistochemical analyses lung. significantly depressed LV but not right (RV) inotropic lusitropic functions. AB decreased in both hypoxia. RV weaker. Hypoxic showed signs moderate PE This was accompanied by elevated levels tumor necrosis factor α (TNFα) nitrotyrosine, a marker stress lungs. In hypoxia, all types markedly reduced TNFα nitrotyrosine. However, did attenuate PE. The results suggest that hypoxia-induced activation contributes inflammation lungs aggravates backlog into circulation, thus promoting

Language: Английский

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Impact of the Menstrual Cycle on the Cardiovascular and Ventilatory Responses During Exercise in Normoxia and Hypoxia

High Altitude Medicine & Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Citherlet, Tom, Antoine Raberin, Giorgio Manferdelli, Nicolas Bourdillon, and Grégoire P Millet. Impact of the menstrual cycle (MC) on cardiovascular ventilatory responses during exercise in normoxia hypoxia.

Language: Английский

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Effects of Acute Hypoxic Exposure in Simulated Altitude in Healthy Adults on Cognitive Performance: A Systematic Review and Meta-Analysis

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 835 - 835

Published: Oct. 17, 2024

The neurocognitive response following hypoxia has received special interest. However, it is necessary to understand the impact of acute hypoxic exposure induced by simulated altitude on cognitive performance. This study aimed determine effects in healthy adults reaction time, accuracy, memory, and attention. Five electronic databases were searched. inclusion criteria were: (1) Experimental studies involving a intervention air generator performance; (2) Conducted (males and/or females; aged 18–50 years) without pathologies or health/mental problems. Four meta-analyses performed: (3) (4) Finally, 37 included meta-analysis. Hypoxia detrimental time (standard mean difference (SMD) −0.23; 95% confidence interval (CI) −0.38–−0.07; p = 0.004), accuracy (SMD −0.20; CI −0.38–−0.03; 0.02), memory −0.93; CI: −1.68–−0.17; 0.02). Nevertheless, attention was not affected during −0.06; −0.23–0.11; 0.47). Acute controlled lab conditions appears be performance, specifically memory.

Language: Английский

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Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51

Progress in brain research, Journal Year: 2021, Volume and Issue: unknown, P. e3 - e4

Published: Jan. 1, 2021

Language: Английский

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