The normal distribution of the hypoxic ventilatory response and methodological impacts: a meta‐analysis and computational investigation DOI Creative Commons

Britney Oeung,

Kathy Pham, I. Mark Olfert

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(19), P. 4423 - 4440

Published: Aug. 17, 2023

Abstract The hypoxic ventilatory response (HVR) is the increase in breathing to reduced arterial oxygen pressure. Over several decades, studies have revealed substantial population‐level differences magnitude of HVR as well significant inter‐individual variation. In particular, low HVRs occur frequently Andean high‐altitude native populations. However, our group conducted hundreds measures over years and commonly observed responses sea‐level populations well. As a result, we aimed determine normal distribution, whether were common, what extent variation study protocols influence these findings. We comprehensive search literature examined distributions values across 78 that utilized step‐down/steady‐state or progressive hypoxia methods untreated, healthy human subjects. Several included multiple datasets different experimental conditions. final analysis, 72 reported mean 60 provided raw datasets. Of reporting values, 35 (58.3%) at least moderately positively skewed (skew > 0.5), 21 (35%) significantly 1), indicating lower are common. skewness does not appear be an artifact methodology unit with which reported. Further analysis demonstrated use step‐down versus did impact on average but isocapnic produced higher than poikilocapnic protocols. This work provides reference for expected illustrates this key reflex. Finally, prevalence general population insight into understanding blunted adapted groups. image Key points plays crucial role determining individual's predisposition hypoxia‐related pathologies. There notable variability sensitivity individuals differences. report distribution skewed, amongst population. also find no protocol used induce hypoxia, although greater methods. These results provide HVR, could useful clinical decisions diseases related hypoxaemia. Additionally, found within genetic adaptations residing high altitudes.

Language: Английский

Smart oxygen monitoring in hospitals: a pilot study during COVID-19 DOI Creative Commons
Jan Velička, Martin Pieš, Radovan Hájovský

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

During 2020-2021, the COVID-19 pandemic exposed significant vulnerabilities in hospital safety, with oxygen-related fires and explosions occurring at twice usual rate. This highlighted insufficient preparedness for increased oxygen therapy demands associated risks of oxygen-enriched atmospheres. study aimed to develop test a smart monitoring system detect concentrations environments, mitigating risk fires. Based on Internet Things (IoT) technology, includes wireless sensors that measure levels regular intervals transmit data database. Alerts are sent staff via short message service e-mail when exceed predefined thresholds. The were deployed an intensive care unit validated through real-time measurements under conditions. demonstrated high accuracy (±1%) low power consumption (345 µA concentration taken every minute). Notifications reliably informed level thresholds, enabling timely interventions. proposed IoT-based is cost-effective efficient solution improving safety medical environments.

Language: Английский

Citations

0
Happy Hypoxia With SARS-CoV-2 Pneumonitis: A Life-Threatening Case of a Medical Doctor DOI Open Access
Jigyasa Sharma, Padmini Yadav,

Rahim R Sewani

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The second wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had devastating consequences in developing countries like Nepal and India. SARS-CoV-2 affected everyone, encompassing all professions, age brackets, socioeconomic levels. Symptoms, along with the reverse transcription-polymerase chain reaction (RT-PCR) results, were primary factors used to determine whether patients should be instructed quarantine at home or admitted hospitals immediately. Happy hypoxia refers a situation where patient shows no symptoms yet experiences decline oxygen saturation This drop can go unnoticed, potentially resulting sudden deterioration patient's condition, reports fatalities occurring. We present case involving physician who experienced sore throat fever as but distress, decrease 87% 82% hospital, near-fatal situation.

Language: Английский

Citations

0
Predicting respiratory failure for COVID-19 patients in Japan: a simple clinical score for evaluating the need for hospitalisation DOI Creative Commons
Gen Yamada, Kayoko Hayakawa, Nobuaki Matsunaga

et al.

Epidemiology and Infection, Journal Year: 2021, Volume and Issue: 149

Published: Jan. 1, 2021

Abstract Predicting the need for hospitalisation of patients with coronavirus disease 2019 (COVID-19) is important preventing healthcare disruptions. This observational study aimed to use COVID-19 Registry Japan (COVIREGI-JP) develop a simple scoring system predict respiratory failure due using only underlying diseases and symptoms. A total 6873 admitted Japanese medical institutions between 1 June 2020 2 December were included divided into derivation validation cohorts according date admission. We used multivariable logistic regression analysis create risk score model, as outcome young (18–39 years), middle-aged (40–64 years) older (≥65 groups, sex, age, body mass index, history The models selected each age group quite different. Areas under receiver operating characteristic curves model 0.87, 0.79 0.80 young, elderly cohorts, 0.81, 0.67 in cohorts. Calibration was good. may be useful appropriate allocation resources during pandemic.

Language: Английский

Citations

22
Time Domains of Hypoxia Responses and -Omics Insights DOI Creative Commons
James J. Yu, Amy L. Non, Erica C. Heinrich

et al.

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 8, 2022

The ability to respond rapidly changes in oxygen tension is critical for many forms of life. Challenges homeostasis, specifically the contexts evolutionary biology and biomedicine, provide important insights into mechanisms hypoxia adaptation tolerance. Here we synthesize findings across varying time domains terms delivery, ranging from early animal modern human evolution examine potential impacts environmental clinical challenges through emerging multi-omics approaches. We discuss how diverse species have adapted hypoxic environments, humans vary their responses (i.e., context high-altitude exposure, cardiopulmonary disease, sleep apnea), each these fields inform other lead promising new directions basic research.

Language: Английский

Citations

15
The normal distribution of the hypoxic ventilatory response and methodological impacts: a meta‐analysis and computational investigation DOI Creative Commons

Britney Oeung,

Kathy Pham, I. Mark Olfert

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(19), P. 4423 - 4440

Published: Aug. 17, 2023

Abstract The hypoxic ventilatory response (HVR) is the increase in breathing to reduced arterial oxygen pressure. Over several decades, studies have revealed substantial population‐level differences magnitude of HVR as well significant inter‐individual variation. In particular, low HVRs occur frequently Andean high‐altitude native populations. However, our group conducted hundreds measures over years and commonly observed responses sea‐level populations well. As a result, we aimed determine normal distribution, whether were common, what extent variation study protocols influence these findings. We comprehensive search literature examined distributions values across 78 that utilized step‐down/steady‐state or progressive hypoxia methods untreated, healthy human subjects. Several included multiple datasets different experimental conditions. final analysis, 72 reported mean 60 provided raw datasets. Of reporting values, 35 (58.3%) at least moderately positively skewed (skew > 0.5), 21 (35%) significantly 1), indicating lower are common. skewness does not appear be an artifact methodology unit with which reported. Further analysis demonstrated use step‐down versus did impact on average but isocapnic produced higher than poikilocapnic protocols. This work provides reference for expected illustrates this key reflex. Finally, prevalence general population insight into understanding blunted adapted groups. image Key points plays crucial role determining individual's predisposition hypoxia‐related pathologies. There notable variability sensitivity individuals differences. report distribution skewed, amongst population. also find no protocol used induce hypoxia, although greater methods. These results provide HVR, could useful clinical decisions diseases related hypoxaemia. Additionally, found within genetic adaptations residing high altitudes.

Language: Английский

Citations

9