European Journal of Sport Science,
Journal Year:
2024,
Volume and Issue:
24(6), P. 812 - 823
Published: March 18, 2024
Abstract
We
aimed
to
assess
the
effects
of
muscle
disuse
on
strength
(MS),
mass
(MM)
and
cardiovascular
fitness.
Databases
were
scrutinized
identify
human
studies
assessing
both
(1)
MM
(2)
maximal
oxygen
uptake
(VO
2max
)
and/or
MS.
Random‐effects
meta‐analysis
meta‐regression
with
initial
physical
fitness
length
protocol
as
a
priori
determined
moderators
performed.
quantitatively
analyzed
51
different
studies,
level
significance
was
set
at
p
<
0.05.
Data
from
participants
in
14
showed
decline
VO
(SMD:
−0.93;
95%
CI:
−1.27
−0.58)
−0.34;
−0.57
−0.10).
47
(−0.88;
−1.04
−0.73)
−0.47;
−0.58
−0.36).
MS
loss
twice
high
loss,
but
differences
existed
between
anatomical
regions.
Notably,
analysis
revealed
that
inversely
associated
decline.
higher
extent
than
during
disuse.
reported
more
profound
subjects
muscular
strength.
This
is
physiologically
relevant
for
athletes
because
their
required
can
profoundly
period
It
should
however
be
noted
have
devastating
consequences
old
low
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
240(3)
Published: Jan. 31, 2024
Abstract
Aim
Altered
mitochondrial
function
across
various
tissues
is
a
key
determinant
of
spaceflight‐induced
physical
deconditioning.
In
comparison
to
tissue
biopsies,
blood
cell
bioenergetics
holds
promise
as
systemic
and
more
readily
accessible
biomarker,
which
was
evaluated
during
head‐down
tilt
bed
rest
(HDTBR),
an
established
ground‐based
analog
for
physiological
changes
in
humans.
More
specifically,
this
study
explored
the
effects
HDTBR
exercise
countermeasure
on
respiration
peripheral
mononuclear
cells
(PBMCs).
Methods
We
subjected
24
healthy
participants
strict
30‐day
protocol.
The
control
group
(
n
=
12)
underwent
only,
while
engaged
regular
supine
cycling
followed
by
veno‐occlusive
thigh
cuffs
post‐exercise
6
h.
assessed
routine
parameters
14
days
before
rest,
respiratory
capacity
PBMCs
via
high‐resolution
respirometry,
citrate
synthase
activity
2
at
day
30
rest.
confirmed
PBMC
composition
flow
cytometry.
Results
change
maximal
oxidative
phosphorylation
(OXPHOS)
amounted
11%
increase
group,
it
decreased
10%
p
0.04).
limitation
OXPHOS
increased
only
other
states
were
not
affected
either
intervention.
Correlation
analysis
revealed
positive
associations
between
white
cells,
lymphocytes,
basophils
with
both
groups.
Conclusion
This
reveals
that
has
impact
function,
confirming
potential
application
human
spaceflight.
Medicine & Science in Sports & Exercise,
Journal Year:
2022,
Volume and Issue:
55(3), P. 482 - 496
Published: Oct. 26, 2022
ABSTRACT
Purpose
Premature
birth
induces
long-term
sequelae
on
the
cardiopulmonary
system,
leading
to
reduced
exercise
capacity.
However,
mechanisms
of
this
functional
impairment
during
incremental
remain
unclear.
Also,
a
blunted
hypoxic
ventilatory
response
was
found
in
preterm
adults,
suggesting
an
increased
risk
for
adverse
effects
hypoxia
population.
This
study
aimed
investigate
oxygen
cascade
exhaustion
both
normoxia
and
hypobaric
prematurely
born
adults
with
normal
lung
function
their
term
counterparts.
Methods
Noninvasive
measures
gas
exchange,
cardiac
hemodynamics,
muscle
cerebral
oxygenation
were
continuously
performed
using
metabolic
cart,
transthoracic
impedance,
near-infrared
spectroscopy,
respectively,
test
at
sea
level
after
3
d
high-altitude
exposure
healthy
(
n
=
17;
gestational
age,
29
±
1
wk;
function)
17)
adults.
Results
At
peak,
power
output,
uptake,
stroke
volume
indexed
body
surface
area,
output
lower
compared
P
0.042,
0.027,
0.030,
0.018,
respectively)
but
not
hypoxia,
whereas
pulmonary
ventilation,
peripheral
saturation,
similar
between
groups.
These
later
parameters
modified
by
<
0.001).
Hypoxia
extraction
submaximal
maximal
intensity
0.05)
participants.
decreased
saturation
rest
0.05).
Convective
delivery
0.001)
diffusive
transport
similarly
groups
0.001
0.001,
respectively).
Conclusions
results
suggest
that
capacity
is
primarily
impaired
convective,
rather
than
diffusive,
transport.
Moreover,
may
experience
hypoxia-induced
impairments
European Journal of Applied Physiology,
Journal Year:
2024,
Volume and Issue:
124(7), P. 2069 - 2079
Published: Feb. 24, 2024
Different
strategies
for
near-infrared
spectroscopy
(NIRS)-derived
muscle
oxidative
capacity
assessment
have
been
reported.
This
study
compared
and
evaluated
(I)
approaches
averaging
trials;
(II)
NIRS
signals
blood
volume
correction
equations;
(III)
the
of
vastus
lateralis
(VL)
tibialis
anterior
(TA)
muscles
in
two
fitness
levels
groups.
European Journal of Sport Science,
Journal Year:
2024,
Volume and Issue:
24(6), P. 812 - 823
Published: March 18, 2024
Abstract
We
aimed
to
assess
the
effects
of
muscle
disuse
on
strength
(MS),
mass
(MM)
and
cardiovascular
fitness.
Databases
were
scrutinized
identify
human
studies
assessing
both
(1)
MM
(2)
maximal
oxygen
uptake
(VO
2max
)
and/or
MS.
Random‐effects
meta‐analysis
meta‐regression
with
initial
physical
fitness
length
protocol
as
a
priori
determined
moderators
performed.
quantitatively
analyzed
51
different
studies,
level
significance
was
set
at
p
<
0.05.
Data
from
participants
in
14
showed
decline
VO
(SMD:
−0.93;
95%
CI:
−1.27
−0.58)
−0.34;
−0.57
−0.10).
47
(−0.88;
−1.04
−0.73)
−0.47;
−0.58
−0.36).
MS
loss
twice
high
loss,
but
differences
existed
between
anatomical
regions.
Notably,
analysis
revealed
that
inversely
associated
decline.
higher
extent
than
during
disuse.
reported
more
profound
subjects
muscular
strength.
This
is
physiologically
relevant
for
athletes
because
their
required
can
profoundly
period
It
should
however
be
noted
have
devastating
consequences
old
low
