Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2540 - 2540
Published: Nov. 7, 2024
The
impressive
achievements
made
in
the
last
century
extending
lifespan
have
led
to
a
significant
growth
rate
of
elderly
individuals
populations
across
world
and
an
exponential
increase
incidence
age-related
conditions
such
as
cardiovascular
diseases,
diabetes
mellitus
type
2,
neurodegenerative
diseases.
To
date,
geroscientists
identified
12
hallmarks
aging
(genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
impaired
macroautophagy,
mitochondrial
dysfunction,
nutrient
sensing,
cellular
senescence,
stem
cell
exhaustion,
defective
intercellular
communication,
chronic
inflammation,
gut
dysbiosis),
intricately
linked
among
each
other,
which
can
be
targeted
with
senolytic
or
senomorphic
drugs,
well
more
aggressive
approaches
cell-based
therapies.
side
effects
seriously
limit
use
these
drugs.
However,
since
rejuvenation
is
dream
mankind,
future
research
expected
improve
tolerability
available
drugs
highlight
novel
strategies.
In
meantime,
medical
community,
healthcare
providers,
society
should
decide
when
start
treatments
how
tailor
them
individually.
Nutrients,
Journal Year:
2023,
Volume and Issue:
16(1), P. 54 - 54
Published: Dec. 23, 2023
During
the
COVID-19
pandemic,
an
increase
in
incidence
of
overweight
and
obesity
children
was
observed.
It
appears
that
unhealthy
food
choices,
unbalanced
diet,
a
sedentary
lifestyle,
as
well
experiencing
stress
related
to
may
be
contributing
this
disturbing
trend.
Chronic
is
significant
factor
eating
disorders
youngsters,
involving
medical,
molecular,
psychological
elements.
Individuals
under
chronic
often
focus
on
appearance
weight,
leading
negative
body
image
disrupted
relationships
with
food,
resulting
behaviors.
also
impacts
hormonal
balance,
reducing
satiety
hormone
leptin
elevating
appetite-stimulating
ghrelin,
fostering
increased
hunger
uncontrolled
snacking.
Two
systems,
hypothalamic–pituitary–adrenal
axis
sympathetic
system
adrenal
medulla,
are
activated
response
stress,
causing
impaired
secretion
noradrenaline
cortisol.
Stress-related
mechanisms
encompass
oxidative
neuroinflammation,
insulin
resistance,
neurohormonal
neurotransmission
disorders.
Stress
induces
risk
by
disrupting
blood
sugar
regulation
fat
storage.
affects
gut
microbiome,
potentially
influencing
inflammation
metabolic
processes
linked
obesity.
In
conclusion,
multifaceted
for
children,
necessitating
comprehensive
understanding
effective
preventive
intervention
strategies
amid
escalating
prevalence
childhood
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2540 - 2540
Published: Nov. 7, 2024
The
impressive
achievements
made
in
the
last
century
extending
lifespan
have
led
to
a
significant
growth
rate
of
elderly
individuals
populations
across
world
and
an
exponential
increase
incidence
age-related
conditions
such
as
cardiovascular
diseases,
diabetes
mellitus
type
2,
neurodegenerative
diseases.
To
date,
geroscientists
identified
12
hallmarks
aging
(genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
impaired
macroautophagy,
mitochondrial
dysfunction,
nutrient
sensing,
cellular
senescence,
stem
cell
exhaustion,
defective
intercellular
communication,
chronic
inflammation,
gut
dysbiosis),
intricately
linked
among
each
other,
which
can
be
targeted
with
senolytic
or
senomorphic
drugs,
well
more
aggressive
approaches
cell-based
therapies.
side
effects
seriously
limit
use
these
drugs.
However,
since
rejuvenation
is
dream
mankind,
future
research
expected
improve
tolerability
available
drugs
highlight
novel
strategies.
In
meantime,
medical
community,
healthcare
providers,
society
should
decide
when
start
treatments
how
tailor
them
individually.
