Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions DOI
Richa Sirmaur, Rishikesh Narayanan

Published: July 8, 2024

Abstract Local field potentials (LFPs) are compound signals that represent the dynamic flow of information across brain, which have been historically associated with chemical synaptic inputs. How do gap junctional inputs onto active compartments shape LFPs? We developed methodology to record extracellular different patterns conductance-based models. found synchronous through synapses yielded a negative deflection in proximal electrodes, whereas those junctions manifested positive deflection. Importantly, we observed dipoles only when arrived synapses, but not junctions. Remarkably, hyperpolarization-activation cyclic nucleotide-gated channels, typically conduct inward currents, mediated outward currents triggered by fast voltage transition caused With rhythmic at frequencies arriving junctions, strong suppression LFP power higher as well frequency-dependent differences spike phase LFP, compared respective counterparts. All were relative dominance vs . voltage-driven transmembrane respectively. Our analyses unveil hitherto unknown role for dendritic shaping potentials.

Language: Английский

Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions DOI Open Access
Richa Sirmaur, Rishikesh Narayanan

Published: Feb. 26, 2025

Local field potentials (LFPs) are compound signals that represent the dynamic flow of information across brain, which have been historically associated with chemical synaptic inputs. How do gap junctional inputs onto active compartments shape LFPs? We developed methodology to record extracellular different patterns conductance-based models. found synchronous through synapses yielded a negative deflection in proximal electrodes, whereas those junctions manifested positive deflection. Importantly, we observed dipoles only when arrived synapses, but not junctions. Remarkably, hyperpolarization-activation cyclic nucleotide-gated channels, typically conduct inward currents, mediated outward currents triggered by fast voltage transition caused With rhythmic at frequencies arriving junctions, strong suppression LFP power higher as well frequency-dependent differences spike phase LFP, compared respective counterparts. All were relative dominance vs . voltage-driven transmembrane respectively. Our analyses unveil hitherto unknown role for dendritic shaping potentials.

Language: Английский

Citations

0
Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions DOI Open Access
Richa Sirmaur, Rishikesh Narayanan

Published: Feb. 26, 2025

Local field potentials (LFPs) are compound signals that represent the dynamic flow of information across brain, which have been historically associated with chemical synaptic inputs. How do gap junctional inputs onto active compartments shape LFPs? We developed methodology to record extracellular different patterns conductance-based models. found synchronous through synapses yielded a negative deflection in proximal electrodes, whereas those junctions manifested positive deflection. Importantly, we observed dipoles only when arrived synapses, but not junctions. Remarkably, hyperpolarization-activation cyclic nucleotide-gated channels, typically conduct inward currents, mediated outward currents triggered by fast voltage transition caused With rhythmic at frequencies arriving junctions, strong suppression LFP power higher as well frequency-dependent differences spike phase LFP, compared respective counterparts. All were relative dominance vs . voltage-driven transmembrane respectively. Our analyses unveil hitherto unknown role for dendritic shaping potentials.

Language: Английский

Citations

0
Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions DOI
Richa Sirmaur, Rishikesh Narayanan

Published: July 8, 2024

Abstract Local field potentials (LFPs) are compound signals that represent the dynamic flow of information across brain, which have been historically associated with chemical synaptic inputs. How do gap junctional inputs onto active compartments shape LFPs? We developed methodology to record extracellular different patterns conductance-based models. found synchronous through synapses yielded a negative deflection in proximal electrodes, whereas those junctions manifested positive deflection. Importantly, we observed dipoles only when arrived synapses, but not junctions. Remarkably, hyperpolarization-activation cyclic nucleotide-gated channels, typically conduct inward currents, mediated outward currents triggered by fast voltage transition caused With rhythmic at frequencies arriving junctions, strong suppression LFP power higher as well frequency-dependent differences spike phase LFP, compared respective counterparts. All were relative dominance vs . voltage-driven transmembrane respectively. Our analyses unveil hitherto unknown role for dendritic shaping potentials.

Language: Английский

Citations

0