Phenotype of early-onset fetal growth restriction in sheep

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

Introduction Fetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve or organ FGR, animal models essential mimic the physiological adaptations FGR assess potential interventions. This study aimed identify temporal nature of reduced developmental trajectory fetuses examine effects factors that may mediate differential such as glucocorticoid treatment. We hypothesised would be adversely impacted FGR. Methods was induced via surgical insufficiency fetal sheep (89 days gestation/0.6 gestation; n=135) compared age-matched controls over last third gestation into neonatal life (n=153). Results Body weight fetuses/lambs significantly (p<0.0001) from 127 (term 148 days), increased brain:body ratio indicative brain sparing. All biometric measures body size were group exception biparietal (head) diameter. The trimester controls, stillbirth rate longer gestation. Discussion work provides well characterised model mimics known human can used determine efficacy

Language: Английский

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Long-term neurologic consequences following fetal growth restriction; the impact on brain reserve.

Developmental Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: May 14, 2024

<b><i>Background:</i></b> Fetal growth restriction (FGR) corresponds to the fetus’s inability achieve an adequate weight gain based on genetic potential and gestational age. It is important cause of morbidity mortality. <b><i>Summary:</i></b> In this review, we address challenges diagnosis classification FGR. We review how chronic fetal hypoxia impacts brain development. describe recent advances placental imaging using magnetic resonance they offer new noninvasive means study in humans. go impact FGR integrity neonatal period, later childhood, adulthood available therapies. <b><i>Key Messages:</i></b> consequences are not limited perinatal period. hypothesize that impaired reserve, as defined by structure size, may predict some concerning epidemiological data cognitive outcomes dementia with aging group patients.

Language: Английский

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Cardiovascular responses to mild perinatal asphyxia in growth-restricted preterm lambs

AJP Heart and Circulatory Physiology, Journal Year: 2023, Volume and Issue: 325(5), P. H1081 - H1087

Published: Sept. 1, 2023

Preterm growth-restricted lambs maintain carotid blood flow for longer than control during asphyxia and have a lower requirement chest compressions resuscitation. growth-restricted, but not control, displayed an overshoot in following return of spontaneous circulation.

Language: Английский

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Hypoxia 2023: physiological mechanisms of adaptation

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(21), P. 5405 - 5407

Published: Sept. 19, 2024

Language: Английский

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