Delay- and Pressure-Dependent Neuromodulatory Effects of Transcranial Ultrasound Stimulation

Neuromodulation Technology at the Neural Interface, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Despite the growing interest in transcranial focused ultrasound stimulation (TUS), our understanding of its underlying mechanisms remains limited. In this study, we aimed to investigate effects TUS on several functional magnetic resonance imaging metrics by considering their latency, duration, and relationship with applied acoustic pressure. We recruited 22 healthy volunteers used a pre- vs post-TUS protocol. Half were stimulated right inferior frontal cortex other half thalamus. The fractional amplitudes low-frequency fluctuations, regional homogeneity, degree centrality, local connectivity density, eigenvector centrality considered. These compared before at three different time points first hour after TUS. Our results showed that 1) primarily alters both global levels; 2) stronger alterations are observed when delay increases 3) pressure is close maximum. suggest some consequences might not be immediate, inviting us revise premise immediate will progressively disappear.

Language: Английский

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Non-invasive brain stimulation to modulate neural activity in Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 5, 2025

Despite its potential to modulate brain and network activity, non-invasive stimulation is not yet clinically applied for treating Parkinson's disease. We here review recent findings that illustrate how various techniques can modify pathological compensatory activities. Due unavoidable heterogeneities low effect sizes of the reviewed studies, a deeper understanding mechanisms action will be critical refining clinical effectiveness generating consistent results.

Language: Английский

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Advances in cell-penetrating peptide-based nose-to-brain drug delivery systems

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125598 - 125598

Published: April 1, 2025

Language: Английский

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Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 28, 2025

Language: Английский

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Neuromodulation using transcranial focused ultrasonography in neonates with perinatal hypoxic-ischemic encephalopathy

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 191, P. 111463 - 111463

Published: Aug. 19, 2024

Language: Английский

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