Extreme altitude‐induced central sleep apneas lasting more than 100 seconds in a healthy 23‐year‐old man DOI
Grégory Heiniger,

Arton Peci,

Nicola Andrea Marchi

et al.

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Summary Central sleep apneas (CSA) can occur de novo at high‐altitude in individuals without sleep‐disordered breathing low altitude. These are usually brief, lasting only 5–15 s. This report presents the first documented case of a man experiencing extreme altitude‐induced CSA more than 100 s absence any disorder normoxia. A 23‐year‐old male with no pre‐existing health conditions was recruited for study examining work during simulated altitude 3500 m (FiO 2 :13%). lowland polysomnography conducted to exclude moderate severe and showed an apnea–hypopnea index (AHI) 7.6/h, oxygen desaturation (ODI) 4.8/h, mean pulse oximetry‐based saturation (SpO ) 93.9%. During recording hypoxic chamber, participant experienced prolonged up 1 min 49 were associated significant desaturations (nadir: 44%). To investigate origin these atypical CSA, underwent new low‐altitude transcutaneous CO measurement (mean PaCO :46 mmHg) diurnal arterial blood gas analysis (pH: 7.42, pCO : 35.1 mmHg, pO 79.9 HCO 3 − 22.4 mmol/L). results indicated signs chronic hypercapnia or hypocapnia. hypoxia tolerance test 11.5%) demonstrated good ventilatory response exercise (1.004 L/min/kg). rebreathing according Read protocol hyperoxia impaired (<0.6 L/min/mmHg). documents rare form hypoxia‐induced potentially caused by chemoreceptor sensitivity increased arousal threshold.

Language: Английский

Altered breathing pattern of lowlanders sleeping at high altitude: novel insights from home sleep apnoea tests procedures DOI Creative Commons

P Prosperi,

Antonella Spacone,

Alberto Taverna

et al.

Respiratory Physiology & Neurobiology, Journal Year: 2025, Volume and Issue: unknown, P. 104415 - 104415

Published: March 1, 2025

Lowlanders sojourning at high altitude often experience sleep disturbances, which are driven by blood gases alterations and manifest as stress-related patterns, including frequent awakenings, apnoeas, reduction in duration possibly with the occurrence of periodic breathing. This study demonstrated clinical evidence disturbances using portable device during a Himalayan expedition. The home apnoea test was conducted on 10 participants taking part "Lobuche Peak - Pyramid Exploration & Physiology". longitudinal design included five assessments, before expedition, pre-expedition Kathmandu (≈1,400m), peak ≈5,000m, upon return to one month after Italy. Total time below 7h highest all participants. Nocturnal SpO2 dropped daytime measurement greatly reduced altitude; conversely, heart rate increased. All experienced an increase apnea-hypopnea index altitude, seven out falling moderate-to-severe grade. Periodic breathing pattern clearly observed two participants, whom developed acute mountain sickness did not. impairments were fully reversible once back low altitude. Translationally, our findings underscore importance conducting tests living Sleep-disordered arises from complex that can be due wide range responses, overall functions revealed testing field expedition have potential safety sojourners, while advancing knowledge hypoxia red line linking respiratory environmental physiology.

Language: Английский

Citations

0
REM sleep breathing: Insights beyond conventional respiratory metrics DOI
Robert J. Thomas

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Summary Breathing and sleep state are tightly linked. The traditional approach to evaluation of breathing in rapid eye movement has been focus on apneas hypopneas, associated hypoxia or hypercapnia. However, offers novel insights into physiology pathology, secondary complex interactions cardiorespiratory biology. In this review, morphological analysis clinical polysomnogram data assess respiratory patterns associations across a range health disease is presented. There several relatively unique that may be evident by assessment during sleep. These include the original discovery scoring neonatal sleep, control homeostasis, apnea endotyping pharmacotherapy, stability, non‐electroencephalogram staging, influences cataplexy, mimics behaviour disorder, reflection autonomic health, cardiac arrhythmogenesis. summary, there rich clinically actionable information beyond encoded

Language: Английский

Citations

1
Effects of Naltrexone on Sleep Quality and Periodic Breathing at High Altitude DOI

Katharine Foster,

James D. Anholm, Gary P. Foster

et al.

High Altitude Medicine & Biology, Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Foster, Katharine, James D. Anholm, Gary Suman Thapamagar, and Prajan Subedi. Effects of naltrexone on sleep quality periodic breathing at high altitude.

Language: Английский

Citations

0
Hypoxia 2023: physiological mechanisms of adaptation DOI
Mike Stembridge, Philip N. Ainslie

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(21), P. 5405 - 5407

Published: Sept. 19, 2024

Language: Английский

Citations

0
Extreme altitude‐induced central sleep apneas lasting more than 100 seconds in a healthy 23‐year‐old man DOI
Grégory Heiniger,

Arton Peci,

Nicola Andrea Marchi

et al.

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Summary Central sleep apneas (CSA) can occur de novo at high‐altitude in individuals without sleep‐disordered breathing low altitude. These are usually brief, lasting only 5–15 s. This report presents the first documented case of a man experiencing extreme altitude‐induced CSA more than 100 s absence any disorder normoxia. A 23‐year‐old male with no pre‐existing health conditions was recruited for study examining work during simulated altitude 3500 m (FiO 2 :13%). lowland polysomnography conducted to exclude moderate severe and showed an apnea–hypopnea index (AHI) 7.6/h, oxygen desaturation (ODI) 4.8/h, mean pulse oximetry‐based saturation (SpO ) 93.9%. During recording hypoxic chamber, participant experienced prolonged up 1 min 49 were associated significant desaturations (nadir: 44%). To investigate origin these atypical CSA, underwent new low‐altitude transcutaneous CO measurement (mean PaCO :46 mmHg) diurnal arterial blood gas analysis (pH: 7.42, pCO : 35.1 mmHg, pO 79.9 HCO 3 − 22.4 mmol/L). results indicated signs chronic hypercapnia or hypocapnia. hypoxia tolerance test 11.5%) demonstrated good ventilatory response exercise (1.004 L/min/kg). rebreathing according Read protocol hyperoxia impaired (<0.6 L/min/mmHg). documents rare form hypoxia‐induced potentially caused by chemoreceptor sensitivity increased arousal threshold.

Language: Английский

Citations

0