Effects of social isolation on locus coeruleus opioid receptor expression and affective behavior.

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: unknown, P. 100717 - 100717

Published: March 1, 2025

Language: Английский

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Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: March 26, 2025

The prefrontal cortex (PFC), located at the anterior region of cerebral cortex, is a multimodal association essential for higher-order brain functions, including decision-making, attentional control, memory processing, and regulation social behavior. Structural, circuit-level, functional abnormalities in PFC are often associated with neurodevelopmental disorders. Here, we review recent findings on postnatal development PFC, particular emphasis rodent studies, to elucidate how its structural circuit properties established during critical developmental windows these processes influence adult behaviors. Recent evidence also highlights lasting effects early life stress structure, connectivity, function. We explore potential mechanisms underlying stress-induced alterations, focus epigenetic implications maturation By integrating insights, this provides an overview shaping their health disease.

Language: Английский

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Histone‐deacetylation inhibitors – old tools in new applications may ameliorate the consequences of social isolation on mental health

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(9), P. 1883 - 1884

Published: April 9, 2024

'Happiness is only real when shared' marks the end of motion picture Into Wild, named after corresponding book by Jon Krakauer. Conversely, lack social interaction causes adverse effects. This relationship has been subject to a vast number psychological studies. A new study led Zhen Yan and colleagues at State University New York Buffalo's Jacobs School Medicine Biomedical Sciences (Yan et al., 2024) now provides important insights into how early-life isolation affects mammalian genome, hence potentially human shaping stress responses stress-related aggression. In their study, al. (2024) identified an epigenetic mechanism underlying heightened aggression in mice that experienced stressor early life compared with animals housed groups. They revealed increased deacetylation histones neurons prefrontal cortex, which ultimately considered change expression genes without altering DNA sequence. humans, epigenetics already play role psychiatric disorders such as major depressive disorder. The present data provide might also alter gene humans underlie maladaptation response. series elegant experiments ranging from slice electrophysiology animal behaviour, find altered histone acetylation accompanied excitatory postsynaptic current socially isolated male upon exposure acute stress, putatively resulting activity behavioural phenotype. very well line for synaptic plasticity, addition effect modulate rapidly (Gräff & Tsai, 2013). Thus, strongly point towards leading hyperactivity within frontal networks, impulsive action aggressive behaviour response stressors. Importantly, using histone-deacetylation inhibitors treat these symptoms pharmacologically resulted attenuation were life. Consistent improved group found excitation regions be reduced baseline levels, highlighting not effects on plasticity finally but effectiveness pharmacological interventions targeting epigenetics. These results contribute earlier recent findings changes, methylation deacetylations, described where use was shown facilitate extinction learning went through fear conditioning (Bludau 2023). Including this issue Journal Physiology, observed several brain involved fear, assigning general precipitation stressful situations during Collectively, corroborates significance treatment manifestations. Histone-deacetylation constitute known tools various cancers, they are able suppress rapid growth tumour cells and, combination other drugs, reveal broad range different classes. two drugs used (2024), romidepsin MS-275, target pharmacologically, context cancer therapies (Bondarev 2021). Romidepsin approved United States Food Drug Administration, MS-275 currently clinical trials show less side than romidepsin. raises possibility inhibition prominent avenue disorders. particular interest post-pandemic society, adolescents kids teenagers have suffering isolation, changing society facilitates beings any age. costs coronavirus disease 2019 pandemic measures yet calculated. growing cities increasing anonymity, mankind consequently encounters elevated levels mental health well-being described. Therefore, tackle disadvantages consequences identification targets particularly relevant. research will further strengthen focus field inhibition. It illustrates necessity develop modifications high specificity minimal (Park Kim, 2020). Please note: publisher responsible content or functionality supporting information supplied authors. Any queries (other missing content) should directed author article. None declared. Sole author. Deutsche Forschungsgemeinschaft (DFG): Lars Paeger, 403161218. Open access funding enabled organized Projekt DEAL.

Language: Английский

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Effects of Social Isolation on Locus Coeruleus Opioid Receptor Expression and Affective Behavior

Published: Jan. 1, 2024

Language: Английский

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