The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth

EMBO Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Language: Английский

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Physiology of ageing skeletal muscle and the protective effects of exercise

The Journal of Physiology, Journal Year: 2025, Volume and Issue: 603(1), P. 3 - 6

Published: Jan. 1, 2025

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

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An Integrated Neuromuscular Training Intervention Applied in Primary School Induces Epigenetic Modifications in Disease‐Related Genes: A Genome‐Wide DNA Methylation Study

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 1, 2025

Physical exercise has been shown to induce epigenetic modifications with various health implications, directly affect DNA methylation (DNAm), as well reverse the age. Hence, we aimed identify differential changes and assess age in saliva of 7-9-year-old school children following a 3-month integrated neuromuscular training (INT), explore if any are core genes. Core genes defined high relevance essential importance within human genome. Forty (17 boys 23 girls) were recruited from schools Girona, Spain, allocated into control (N = 20) or INT group. The group performed warm-up during physical education (PE) classes, encompassing strength, coordination, dynamic stabilization, plyometrics, speed, agility exercises, whereas traditional activities, aerobic exercises that will prepare cardiovascular system increase joint mobility for upcoming effort class. Genome-wide DNAm analysis was Illumina 900 K microarray. recognized based on accomplishment rigorous widely accepted 3-point criteria: participation enriched pathways, connectivity (≥ 10), target key transcription factors. There 1200 differentially methylated positions (DMPs) 414 DMPs (FDR < 0.05, p Aβ |0.1|), suggesting non-significant trend acceleration (1.18 months, > 0.05) 1-month decrease (p 0.05). showed low similarity between pathways interconnectivity, distinct mostly development growth-related. Additionally, no identified Interestingly, related involving signaling mechanisms, hormone protein metabolism pathways. Moreover, 17 main findings present study an response stimulus INT, including considered Trial Registration: protocol registered ISRCTN registry (ISRCTN16744821).

Language: Английский

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The Pivotal Role of LACTB in the Process of Cancer Development

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1279 - 1279

Published: Feb. 1, 2025

The mitochondrial serine β-lactamase-like protein LACTB has emerged as a critical regulator in cancer biology, distinguished by its unique structural and functional attributes. Defined conserved penicillin-binding proteins β-lactamases (PBP-βLs) domain SXXK catalytic motif, demonstrates properties distinct from prokaryotic homologs, including the ability to polymerize into filaments. These characteristics enable modulate organization enzymatic activity, influencing lipid metabolism indirectly affecting cellular proliferation. Importantly, expression roles of exhibit cancer-type-specific variation, underscoring dual function both tumor suppressor an oncogene. Decreased is associated with poor clinical outcomes cancers such breast cancer, lung colorectal while specific mutations regulatory mechanisms have been linked oncogenic activity osteosarcoma pancreatic adenocarcinoma. Mechanistically, regulates key processes progression, dynamics, epithelial–mesenchymal transition (EMT), cell death pathways. This duality highlights promising therapeutic target underscores relevance advancing precision oncology strategies. review provides comprehensive analysis level, structure–function relationships, diverse oncogenesis, promise focal point for therapies.

Language: Английский

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A primer on global molecular responses to exercise in skeletal muscle: Omics in focus

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101029 - 101029

Published: Feb. 1, 2025

Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over past 2 decades, transcriptome studies have detailed acute and chronic responses to resistance, endurance, concurrent exercise, focusing on variables such as training status, nutrition, age, sex, metabolic health profile. Multi-omics approaches, integration transcriptomic epigenetic data, along with emerging ribosomal RNA sequencing advancements, further provided insights into how adapts exercise across lifespan. Downstream transcriptome, proteomic phosphoproteomic identified novel regulators adaptations, while single-cell/nucleus spatial technologies promise evolve cellular specialization communication around cells. This narrative review highlights (a) historical foundations muscle, (b) current research 3 layers cascade (DNA, RNA, protein), (c) applications single-cell study adaptation exercise. Further elaboration muscle's global footprint using multi-omics methods will help researchers practitioners develop more effective targeted approaches improve well athletic performance.

Language: Английский

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Epigenome–proteome integration in aged skeletal muscle after exercise training

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 603(1), P. 29 - 31

Published: Sept. 19, 2024

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