Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection
Published: Jan. 14, 2025
Locomotion
is
controlled
by
spinal
circuits
that
interact
with
supraspinal
drives
and
sensory
feedback
from
the
limbs.
These
sensorimotor
interactions
are
disrupted
following
cord
injury.
The
thoracic
lateral
hemisection
represents
an
experimental
model
of
incomplete
injury,
where
connections
between
brain
abolished
on
one
side
cord.
To
investigate
effects
such
injury
operation
locomotor
network,
we
used
our
computational
cat
locomotion
recently
published
in
eLife
(Rybak
et
al.,
2024)
to
predict
changes
cycle
phase
durations
a
during
treadmill
tied-belt
(equal
left-right
speeds)
split-belt
(unequal
conditions.
In
simulations,
“hemisection”
was
always
applied
right
side.
Based
model,
hypothesized
hemisection,
contralesional
(“intact”,
left)
network
mostly
drives,
whereas
ipsilesional
(“hemisected”,
right)
somatosensory
feedback.
We
then
compared
simulated
results
those
obtained
experiments
adult
cats
before
after
mid-thoracic
same
Our
confirmed
many
predicted
simulations.
show
having
hindlimb
step
slow
belt,
but
not
fast
substantially
reduces
hemisection.
provides
explanations
for
temporal
characteristics
based
altered
circuits,
Language: Английский
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection
eLife,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 27, 2025
Locomotion
is
controlled
by
spinal
circuits
that
interact
with
supraspinal
drives
and
sensory
feedback
from
the
limbs.
These
sensorimotor
interactions
are
disrupted
following
cord
injury.
The
thoracic
lateral
hemisection
represents
an
experimental
model
of
incomplete
injury,
where
connections
between
brain
abolished
on
one
side
cord.
To
investigate
effects
such
injury
operation
locomotor
network,
we
used
our
computational
cat
locomotion
recently
published
in
eLife
(Rybak
et
al.,
2024)
to
predict
changes
cycle
phase
durations
a
during
treadmill
tied-belt
(equal
left-right
speeds)
split-belt
(unequal
conditions.
In
simulations,
‘hemisection’
was
always
applied
right
side.
Based
model,
hypothesized
contralesional
(‘intact’,
left)
network
mostly
drives,
whereas
ipsilesional
(‘hemisected’,
right)
somatosensory
feedback.
We
then
compared
simulated
results
those
obtained
experiments
adult
cats
before
after
mid-thoracic
same
Our
confirmed
many
predicted
simulations.
show
having
hindlimb
step
slow
belt,
but
not
fast
substantially
reduces
hemisection.
provides
explanations
for
temporal
characteristics
based
altered
circuits,
Language: Английский
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection
eLife,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Locomotion
is
controlled
by
spinal
circuits
that
interact
with
supraspinal
drives
and
sensory
feedback
from
the
limbs.
These
sensorimotor
interactions
are
disrupted
following
cord
injury.
The
thoracic
lateral
hemisection
represents
an
experimental
model
of
incomplete
injury,
where
connections
between
brain
abolished
on
one
side
cord.
To
investigate
effects
such
injury
operation
locomotor
network,
we
used
our
computational
cat
locomotion
recently
published
in
eLife
(Rybak
et
al.,
2024)
to
predict
changes
cycle
phase
durations
a
during
treadmill
tied-belt
(equal
left-right
speeds)
split-belt
(unequal
conditions.
In
simulations,
“hemisection”
was
always
applied
right
side.
Based
model,
hypothesized
hemisection,
contralesional
(“intact”,
left)
network
mostly
drives,
whereas
ipsilesional
(“hemisected”,
right)
somatosensory
feedback.
We
then
compared
simulated
results
those
obtained
experiments
adult
cats
before
after
mid-thoracic
same
Our
confirmed
many
predicted
simulations.
show
having
hindlimb
step
slow
belt,
but
not
fast
substantially
reduces
hemisection.
provides
explanations
for
temporal
characteristics
based
altered
circuits,
Language: Английский