The biophysics of balanced living: a mechano-homeostasis paradigm for balancing in animals and robots DOI Open Access
Nick Wilkinson

Published: Dec. 14, 2024

From birth until death animals resist gravity, effortfully asserting bodily form, animate behaviour, and postural balance. Most basic negentropic behaviours are understood as homeostasis (e.g. thermoregulation), but balance is taken to be an exception. Many studies have elucidated its sub-mechanisms, the existence of goal-oriented homeostatic organisation remains open question. The current theoretical paper reviews existing work highlight challenge assumptions that belie a model, arguing organised one aspect wider mechano-homeostasis, by control loop organisationally akin thermoregulation. biophysical cost maintaining agent-medium density gradient defines task, which regulation mechanical force. Organism-level mechano-homeostasis must approximately maintain certain force field at surface organism (i.e. precisely cancels gravitational acceleration), or will fall, dissipate die. argument specifies this fluid, dynamical ‘balance’ for arbitrary morphologies configurations, describes how apprehend it developmentally their own embodiment. I motivate define examine against evidence, discuss implications, limitations scope understanding embodied spatiotemporal animacy in robots.

Language: Английский

Homeostasis in the laboratory, the clinic and our academic institutions! DOI Open Access
Ken D. O’Halloran

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

Citations

0
An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics DOI Creative Commons

Shao Feng Yu,

Maya Michon,

Anuradha F. Lingappa

et al.

Clinical Proteomics, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 28, 2025

Abstract Assembly modulators are a new class of allosteric site-targeted therapeutic small molecules, some which effective at restoring nuclear localization TDP-43 in ALS cellular models, and display efficacy variety animal models. These compounds have been shown to bind selectively subset protein disulfide isomerase (PDI), implicated pathophysiology. The targeted PDI is found within novel, transient energy-dependent multi-protein complex that includes other important members the interactome, such as TDP-43, RanGTPase, selective autophagy receptor p62/SQSTM1. We demonstrate here similar drug target present PBMCs isolated by resin affinity chromatography (eDRAC) characterized mass spectrometry Western blot (WB). Signature alterations composition from patients compared healthy individuals were identified WB eDRAC bound proteins, thereby extending earlier literature suggesting PBMC dysfunction ALS. Changes include diminished p62/SQSTM1 appearance 17 kDa post-translationally modified form RanGTPase. changes not readily apparent analysis whole cell extracts, individual components comprise only percentages total those component proteins extract. Furthermore, blood shows distinctive degradation RanGTPase observed individuals. This appears be rescued treatment for 72 h with ALS-active assembly modulator molecules. Our findings consistent hypothesis fundamentally disorder homeostasis can detected early, prior disability, methods described, restored state treatment.

Language: Английский

Citations

0
The biophysics of balanced living: a mechano-homeostasis paradigm for balancing in animals and robots DOI Open Access
Nick Wilkinson

Published: Dec. 14, 2024

From birth until death animals resist gravity, effortfully asserting bodily form, animate behaviour, and postural balance. Most basic negentropic behaviours are understood as homeostasis (e.g. thermoregulation), but balance is taken to be an exception. Many studies have elucidated its sub-mechanisms, the existence of goal-oriented homeostatic organisation remains open question. The current theoretical paper reviews existing work highlight challenge assumptions that belie a model, arguing organised one aspect wider mechano-homeostasis, by control loop organisationally akin thermoregulation. biophysical cost maintaining agent-medium density gradient defines task, which regulation mechanical force. Organism-level mechano-homeostasis must approximately maintain certain force field at surface organism (i.e. precisely cancels gravitational acceleration), or will fall, dissipate die. argument specifies this fluid, dynamical ‘balance’ for arbitrary morphologies configurations, describes how apprehend it developmentally their own embodiment. I motivate define examine against evidence, discuss implications, limitations scope understanding embodied spatiotemporal animacy in robots.

Language: Английский

Citations

0