Collagen remodeling in murine melanoma therapy response through second-harmonic generation imaging DOI Creative Commons
Mihaela Balu

Biophotonics discovery., Journal Year: 2024, Volume and Issue: 1(03)

Published: Dec. 17, 2024

The study by Heaton et al. marks a significant advancement in understanding the role of collagen remodeling within melanoma tumor microenvironment during immunotherapy. Using vivo second-harmonic generation imaging, authors quantitatively tracked dynamic changes morphology preclinical model, revealing shift toward healthier phenotype associated with treatment. These findings enhance our extracellular matrix dynamics and highlight potential optical imaging technologies to guide optimize cancer This commentary will explore these findings, contextualize them broader field immunology, discuss their implications for improving immunotherapy strategies other cancers.

Language: Английский

Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma DOI Creative Commons
Luke Horton,

Joseph W. Fakhoury,

Rayyan Manwar

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(5), P. 297 - 297

Published: May 7, 2025

Imaging technologies are constantly being developed to improve not only melanoma diagnosis, but also staging, treatment planning, and disease progression. We start with a description of how is characterized using histology, then continue by discussing nearly two dozen different technologies, including systems currently used in medical practice those development. For each technology, we describe its method operation, it or would be projected most commonly diagnosing managing melanoma, for current use, identify at least one manufacturer. provide table the biomarkers identified main limitations associated technology conclude offering suggestions on specific characteristics that might best enhance technology’s potential widespread clinical adoption.

Language: Английский

Citations

0
Recombinant humanized type III collagen inhibits ovarian cancer and induces protective anti-tumor immunity by regulating autophagy through GSTP1 DOI Creative Commons
Hui Zeng, Hu Li, Li Wang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101220 - 101220

Published: Sept. 1, 2024

Ovarian cancer (OC) is one of the leading causes death from malignancy in women and lacks safe efficient treatment. The novel biomaterial, recombinant humanized collagen type III (rhCOLIII), has been reported to have various biological functions, but its role OC unclear. This study aimed reveal function mechanism action rhCOLIII OC. We developed an injectable human (rhCOL)-derived material with a molecular weight 45 kDa, stable triple helix structure, high biocompatibility, water solubility biosafety. anti-tumor activity was comprehensively evaluated through

Language: Английский

Citations

2
Quantitative Assessment of Collagen Architecture to Determine Role of Tumor Stroma During Vestibular Schwannoma Progression DOI Creative Commons
Melanie Fisher, Bailey H. Duhon,

Han T. N. Nguyen

et al.

Otolaryngology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Objective The primary objective was to characterize the abundance and architecture of collagen in extracellular matrix vestibular schwannoma (VS). secondary investigate association between tumor size. Study Design Retrospective cohort study. Setting Academic referral center. Methods Tumor samples were obtained from patients with sporadic VS undergoing microsurgical resection. Histological analyses performed including picrosirius red (PSR) staining under polarized light. Collagen quantified using an automated fiber detection software. Second Harmonic Generation (SHG) microscopy immunofluorescence (IF) utilized architecture. Results Eleven specimens included (mean diameter = 2.80 cm, range 1.5‐4.0 cm), divided into large 3.5 ± 0.4 cm) small 2.0 cohorts based on showed significantly higher density (27.65% vs 12.73%, P .0043), more thick fibers (mature Type I, 24.54% 12.97%, .0022) thin (immature I or mature III, 23.55% 12.27%, .026). volume correlated greater degree disorganization ( .0413, r 2 0.298). Specifically, type intensity compared tumors < .001) peripheral nerve .028). Conclusion Larger exhibit increased stroma, a disorganized smaller normal tissue. This finding indicates that organization may play significant role remodeling progression VS.

Language: Английский

Citations

0
Collagen remodeling in murine melanoma therapy response through second-harmonic generation imaging DOI Creative Commons
Mihaela Balu

Biophotonics discovery., Journal Year: 2024, Volume and Issue: 1(03)

Published: Dec. 17, 2024

The study by Heaton et al. marks a significant advancement in understanding the role of collagen remodeling within melanoma tumor microenvironment during immunotherapy. Using vivo second-harmonic generation imaging, authors quantitatively tracked dynamic changes morphology preclinical model, revealing shift toward healthier phenotype associated with treatment. These findings enhance our extracellular matrix dynamics and highlight potential optical imaging technologies to guide optimize cancer This commentary will explore these findings, contextualize them broader field immunology, discuss their implications for improving immunotherapy strategies other cancers.

Language: Английский

Citations

0