Modality-Level Obstacles and Initiatives to Improve Representation in Fetal, Infant, and Toddler Neuroimaging Research Samples

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 72, P. 101505 - 101505

Published: Jan. 5, 2025

Fetal, infant, and toddler (FIT) neuroimaging researchers study early brain development to gain insights into neurodevelopmental processes identify markers of neurobiological vulnerabilities target for intervention. However, the field has historically excluded people from global majority countries marginalized communities in FIT research. Inclusive representative samples are essential generalizing findings across modalities, such as magnetic resonance imaging, magnetoencephalography, electroencephalography, functional near-infrared spectroscopy, cranial ultrasonography. These techniques pose unique overlapping challenges equitable representation research through sampling bias, technical constraints, limited accessibility, insufficient resources. The present article adds conversation around need improve inclusivity by highlighting modality-specific historical current obstacles ongoing initiatives. We conclude discussing tangible solutions that transcend individual ultimately providing recommendations promote neuroscience.

Language: Английский

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The pulsing brain: state of the art and an interdisciplinary perspective

Interface Focus, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

Understanding the pulsing dynamics of tissue and fluids in intracranial environment is an evolving research theme aimed at gaining new insights into brain physiology disease progression. This article provides overview related magnetic resonance imaging, ultrasound medical diagnostics mathematical modelling biological tissues fluids. It highlights recent developments, illustrates current goals emphasizes importance collaboration between these fields.

Language: Английский

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Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 11, 2024

Introduction Interpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, prosocial commitment. Mental disorders characterized by interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment (RAD), Social Anxiety (SAD), often exhibit atypical with others across multiple levels. With introduction “second-person” neuroscience perspective, our understanding interpersonal neural (INS) has improved, however, so far, it hardly impacted development novel therapeutic interventions. Methods To evaluate potential INS-based treatments for mental disorders, we performed two systematic literature searches identifying studies that directly target INS through neurofeedback (12 publications; 9 independent studies) or stimulation techniques (7 studies), following PRISMA guidelines. In addition, narratively review indirect manipulations biofeedback, hormonal We discuss ASD, RAD, SAD using a database search assess acceptability (4 neurostimulation in patients dysfunction. Results Although behavioral approaches, engaging eye contact cooperative actions, have been shown to be associated increased INS, little is known about long-term consequences Few proof-of-concept utilized techniques, like transcranial direct current neurofeedback, showing feasibility preliminary evidence interventions can boost synchrony connectedness. Yet, optimal protocols parameters are still undefined. For SAD, far no randomized controlled trial proven efficacy intervention although general methods seem well accepted these patient groups. Discussion Significant work remains translate into effective disorders. Future research should focus on mechanistic insights technological advancements, rigorous design standards. Furthermore, will key compare targeting those other modalities define dyads clinical

Language: Английский

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Wearable functional near‐infrared spectroscopy for measuring dissociable activation dynamics of prefrontal cortex subregions during working memory

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(2)

Published: Feb. 1, 2024

Abstract The prefrontal cortex (PFC) has been extensively studied in relation to various cognitive abilities, including executive function, attention, and memory. Nevertheless, there is a gap our scientific knowledge regarding the functionally dissociable neural dynamics across PFC during task their individual differences performance. Here, we explored this possibility using delayed match‐to‐sample (DMTS) working memory (WM) NIRSIT, high‐density, wireless, wearable functional near‐infrared spectroscopy (fNIRS) system. First, upon presentation of sample stimulus, observed an immediate signal increase ventral (orbitofrontal) region anterior PFC, followed by activity dorsolateral PFC. After DMTS test stimulus appeared, orbitofrontal activated once again, while rest showed overall disengagement. Individuals with higher accuracy earlier sustained activation trial. Furthermore, network efficiency connectivity were correlated WM Our study sheds new light on subregional its potential applicability explaining experimental, educational, or clinical populations. Practitioner Points Wearable captured temporal subregions task. Anterior regions (OFC) first delay period, (PFC). disengaged after delay, but OFC reactivated stimulus. Earlier was associated better accuracy. Functional also varied

Language: Английский

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Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near‐infrared spectroscopy: A scoping review

Developmental Medicine & Child Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Aim To map and critically appraise the literature on feasibility current use of functional near‐infrared spectroscopy (fNIRS) to assess cortical activity, connectivity, neuroplasticity in individuals with cerebral palsy (CP). Method A scoping review methodology was prospectively registered reported following Preferred Reporting Items for Systematic Meta‐Analysis Extension Scoping Reviews (PRISMA‐ScR) guidelines. systematic search conducted four databases. Empirical studies using fNIRS neural or CP aged 3 years older were included. Results Sixteen met inclusion criteria. Individuals (age range = 3–43 years; 70% unilateral CP) underwent fNIRS‐based assessment task‐evoked activity (studies [ n ] 15) and/or resting‐state connectivity ( 3). Preliminary observations suggest greater magnitude, extent, ipsilateral hemispheric lateralization sensorimotor cortex CP, while magnitude patterns prefrontal appear dependent task demands. Normalization metrics observed postintervention 3) paralleled improvements outcomes, highlighting their potential as promising biomarkers gains CP. Interpretation This details highlights research gaps technical limitations, offers recommendations support implementation ecologically valid neuroimaging

Language: Английский

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Functional connectivity changes in mouse models of maple syrup urine disease

Cerebral Cortex, Journal Year: 2025, Volume and Issue: 35(2)

Published: Feb. 1, 2025

Maple syrup urine disease is a rare metabolic disorder that results in neurodevelopmental injury despite dietary therapy. While structural neuroimaging has shown characteristic pattern of edema and white matter injury, no functional studies maple have been performed. Using widefield optical imaging, we investigated resting-state connectivity two brain-specific mouse models (an astrocyte-specific knockout whole-brain knockout). At 8 weeks, was performed using custom-built imaging system. Imaging before after initiation high-protein diet for 1 week to mimic crisis, which hypothesized would result decreased strength. Data were analyzed seed-based cluster-based inference. Astrocyte-specific mice developed increased contralateral within the posteromedial somatosensory cortex initiation. Whole-brain had similar present at baseline, persisted Thus, contrary expectations, resulted strength, especially underlying etiology these changes unclear, demonstrate inborn errors metabolism networks. Further research may biomarkers could be translated clinical care.

Language: Английский

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Usability and Acceptance Analysis of Wearable BCI Devices

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(7), P. 3512 - 3512

Published: March 23, 2025

In the current scientific and technological scenario, wearable neuroimaging devices represent a revolution in neuroscience technology. These tools combine features of technologies with convenience devices, enabling real-time exploration brain activity real-world contexts. This convergence defines new perspectives research, medical diagnosis, human performance analysis. Technologies such as EEG fNIRS enable non-invasive monitoring without need for heavy clinical equipment. Indeed, miniaturization, portability, wireless communication, energy efficiency are key objectives design advanced devices. comfort is requirement to widespread use different contexts, requiring lightweight minimally invasive The literature review examines impact on user real-life laboratory environments terms usability acceptability. study presents evaluation factors—applied testing—defined improve quality perception experience ensure accuracy cognitive load detection. results will be useful defining applications, future challenges BCI.

Language: Английский

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Continuous Wave-Diffuse Optical Tomography (CW-DOT) in Human Brain Mapping: A Review

Sensors, Journal Year: 2025, Volume and Issue: 25(7), P. 2040 - 2040

Published: March 25, 2025

Continuous wave-diffuse optical tomography (CW-DOT) has emerged as a promising non-invasive neuroimaging technique for assessing brain function. Its ability to provide mapping with high spatial resolution over traditional functional near-infrared spectroscopy (fNIRS) garnered significant interest in clinical and cognitive neuroscience. In this review, we critically summarized the hardware, reconstruction algorithms, applications of CW-DOT human mapping, providing an up-to-date overview guidelines future studies conduct studies. ScienceDirect, PubMed, Web Science, IEEE Xplore databases were searched from their inception up 1 July 2024. A total 83 articles included final systematic review. The review focused on existing hardware systems, algorithms CW-DOT, both settings Finally, highlighted current challenges potential directions research, including absence standardized protocols pressing need enhanced quantitative precision. This underscores sophisticated capabilities particularly realm imaging. Extensive neuroscience research attested technique's anatomical precision reliability, establishing it potent instrument practice.

Language: Английский

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Three-dimensional infrared scanning: an enhanced approach for spatial registration of probes for neuroimaging

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(02)

Published: May 26, 2024

Accurate spatial registration of probes (e.g., optodes and electrodes) for measurement brain activity is a crucial aspect in many neuroimaging modalities. It may increase precision enable the transition from channel-based calculations to volumetric representations.

Language: Английский

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ninjaCap: a fully customizable and 3D printable headgear for functional near-infrared spectroscopy and electroencephalography brain imaging

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(03)

Published: Aug. 27, 2024

Accurate sensor placement is vital for non-invasive brain imaging, particularly functional near-infrared spectroscopy (fNIRS) and diffuse optical tomography (DOT), which lack standardized layouts such as those in electroencephalography (EEG). Custom, manually prepared probe on textile caps are often imprecise labor intensive. We introduce a method creating personalized, 3D-printed headgear, enabling the accurate translation of 3D coordinates to 2D printable panels custom fNIRS EEG while reducing costs manual labor. Our approach uses atlas-based or subject-specific head models spring-relaxation algorithm flattening onto panels, using 10-5 reference. This process ensures geometrical fidelity, crucial placement. Probe geometries holder types customizable printed directly cap, making agnostic instrument manufacturers types. ninjaCap offers 2.7±1.8 mm accuracy. Over last five years, we have developed validated this with over 50 cap 500 participants. A cloud-based generation pipeline along detailed instructions now available at openfnirs.org. The marks significant advancement individualized neuroimaging caps, improving accuracy, thereby variability research.

Language: Английский

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