Successful Modulation of Temporoparietal Junction Activity and Stimulus-Driven Attention by fNIRS-based Neurofeedback – a Randomized Controlled Proof-of-Concept Study DOI Creative Commons
Simon H. Kohl,

Pia Melies,

Johannes Uttecht

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract The right temporoparietal junction (rTPJ) is a core hub in neural networks associated with reorienting of attention and social cognition. However, it remains unknown whether participants can learn to actively modulate their rTPJ activity via neurofeedback. Here, we explored the feasibility functional near-infrared spectroscopy (fNIRS)-based neurofeedback modulating its effect on functions such as visual perspective taking. In bidirectional regulation control group design, 50 healthy were either reinforced up- or downregulate activation over four days training. Both groups showed an increase from beginning trainingbut only upregulation maintained this effect, while downregulation decline initial activation. This suggests learning exclusively, making challenging draw definitive conclusions about effectiveness observed group-specific effects behavioral level. We found significant x time interaction performance task changes, decreased reaction times (RTs) increased RTs across all conditions after Those low baseline greater improvements. perspective-taking task, however, that non-group-specific.These findings demonstrate fNIRS-based feasible method preliminary evidence neurophysiologically specific effects, thus paving way for future applications non-invasive modulation neuropsychiatric disorders. Graphical abstract Highlights attentive socio-cognitive promising target neuromodulatory interventions first single-blinded, randomized controlled study demonstrates training adults subjects are able regulate different characteristics stimulus-driven have important implications clinical translation targeting

Language: Английский

Effects of Home-Based EEG Neurofeedback Training as a Non-Pharmacological Intervention for Parkinson’s Disease DOI Creative Commons
Andrew Cooke, John V. Hindle, Catherine L. Lawrence

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Abstract Aberrant movement-related cortical activity has been linked to impaired motor function in Parkinson’s disease (PD). Dopaminergic drug treatment can restore these, but dosages and long-term are limited by adverse side-effects. This experiment reports the first study of home-based electroencephalographic (EEG) neurofeedback training as a non-pharmacological candidate for PD. Sixteen people with PD received six home visits comprising symptomology self-reports, standardised assessment, precision handgrip force production task while EEG was recorded (visits 1, 2 6); 3 × 1-hr sessions reduce high-alpha power before initiating movements 5). Participants successfully learned self-regulate alpha rhythms, this appeared expedite initiation movements. There no evidence wider reduction. Interviews indicated that intervention well-received. We conclude is feasible warrants further research.

Language: Английский

Citations

0
Successful Modulation of Temporoparietal Junction Activity and Stimulus-Driven Attention by fNIRS-based Neurofeedback – a Randomized Controlled Proof-of-Concept Study DOI Creative Commons
Simon H. Kohl,

Pia Melies,

Johannes Uttecht

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract The right temporoparietal junction (rTPJ) is a core hub in neural networks associated with reorienting of attention and social cognition. However, it remains unknown whether participants can learn to actively modulate their rTPJ activity via neurofeedback. Here, we explored the feasibility functional near-infrared spectroscopy (fNIRS)-based neurofeedback modulating its effect on functions such as visual perspective taking. In bidirectional regulation control group design, 50 healthy were either reinforced up- or downregulate activation over four days training. Both groups showed an increase from beginning trainingbut only upregulation maintained this effect, while downregulation decline initial activation. This suggests learning exclusively, making challenging draw definitive conclusions about effectiveness observed group-specific effects behavioral level. We found significant x time interaction performance task changes, decreased reaction times (RTs) increased RTs across all conditions after Those low baseline greater improvements. perspective-taking task, however, that non-group-specific.These findings demonstrate fNIRS-based feasible method preliminary evidence neurophysiologically specific effects, thus paving way for future applications non-invasive modulation neuropsychiatric disorders. Graphical abstract Highlights attentive socio-cognitive promising target neuromodulatory interventions first single-blinded, randomized controlled study demonstrates training adults subjects are able regulate different characteristics stimulus-driven have important implications clinical translation targeting

Language: Английский

Citations

0