Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients? DOI Open Access

Olivia Kline,

Karthik Vishwanath,

Boyd Colbrunn

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

Abstract Significance Shuntodynia is patient reported pain at the site of implanted ventriculo-peritoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement a chronic and prevalent standard care treatment lifetime management. subjective measure dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in clinic. Aim subjects were recruited for optical sensing during routine clinical follow-up visits, post VP implantations. Acquired signals translated into skin-hemodynamic signatures compared between that shuntodynia vs. those did not. Approach Diffuse reflectance (DRS) measurements collected 450-700 nm using single-channel fiber-optical probe from (N=35) patients. Multiple spectra obtained by attending physician regions both proximal distal sites, matched contralateral each subject. processed quantitatively functional endpoints. A two- way, repeated measures analysis variance (ANOVA) was assess whether which variables statistically separable, across with without. Results showed vascular oxygen saturation significantly lower reporting shuntodynia, when measured sites. Subjects also had total hemoglobin relative Both groups higher scattering sites comparison Conclusions Optically derived hemodynamic different presenting DRS provide viable mode bedside monitoring shunts management risk assessment shuntodynia.

Language: Английский

Measuring Brain Haemodynamic Activity and Afferent Visual Function: A Preliminary Study on the Relationship Between fNIRS, the King–Devick Test and Suspected Sport-Related Concussions DOI Creative Commons
Mark Hecimovich, Terence Moriarty, Doug King

et al.

Physiologia, Journal Year: 2025, Volume and Issue: 5(1), P. 4 - 4

Published: Jan. 7, 2025

Background/Objectives: Functional near-infrared spectroscopy (fNIRS) may help quantify changes in brain haemodynamics during sport-related concussions (SRCs). This study compared post-match prefrontal cortex (PFC) measured by fNIRS the King–-Devick test (K-DT) with players suspected of having sustained an SRC. It was hypothesized that K-DT would correspond haemodynamic processes. Methods: Twenty-two male and female collegiate rugby (six males twenty-two females; age range: 18–22) completed a baseline K-DT+fNIRS assessment. Over course two to three matches, all participants were invited complete at least one If player SRC, they re-assessed K-DT+fNIRS. participant who not SRC performed worse on post-match, included category ‘concussion’ for analysis. A repeated measures ANOVA performed. Test–retest reliability calculated using intra-class correlation coefficient (ICC). Pearson (r) assessed linear relationship between measurements left right PFC. Results: Differences identified concussive injury (χ2(1) =5.0; p = 0.0253; z −2.0; 0.0431; d 0.16). There also significant differences results concussed PFC (t(8) 250; 0.0371; 0.92) females (t(6) 2.78; 0.0319; 0.52). no correlations values group. Conclusions: The group had decreased cognitive performance notable change activation, while non-concussed showed increase activation scores. represents possible acute adjustment provides insight into how SRCs can negatively impact performance.

Language: Английский

Citations

0
Near infrared spectroscopy in the pediatric cardiac intensive care unit: accurately interpreting the data DOI
Ilias Iliopoulos, Saúl Flores, Rohit S. Loomba

et al.

Current Opinion in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Purpose of review Near infrared spectroscopy (NIRS) has been increasingly adopted as standard monitoring in postoperative care pediatric cardiac patients. Several reports have established its association with both markers perfusion and adverse outcomes. The correlation is not strong exhibits wide limit agreement, making the determination critical thresholds integration treatment algorithms challenging. Recent findings A growing body literature support use NIRS for hemodynamic corroborate prior weak to moderate global regional confirm challenge lack remains, limiting clinical utility. Evidence improvement outcomes remains limited. Summary a useful monitor can inform management decisions but cannot be used sole decision-making tool. Large, randomized studies are needed define decision tool facilitate algorithms.

Language: Английский

Citations

0
Time-Domain Diffuse Optical Tomography for Precision Neuroscience DOI Creative Commons

Yaroslav Chekin,

Dakota Decker,

Hamid Dehghani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Recent years have witnessed a rise in research utilizing neuroimaging for precision neuromedicine, but clinical translation has been hindered by scalability and cost. Time Domain functional Near Infrared Spectroscopy (TD-fNIRS), the gold standard of optical techniques, offers unique opportunity this domain since it provides superior depth sensitivity enables resolution absolute properties unlike its continuous wave counterparts. However, current TD systems limited commercial availability, slow sampling rates, sparse head coverage. Our team overcome technical challenges involved developing whole-head time-domain diffuse tomography (TD-DOT) system. Here, we present system characterization results using standardized protocols compare them to state-of-the-art. Furthermore, showcase performance retrieving cortical activation maps during hemodynamic, sensory, motor tasks. A combination performance, signal quality, ease-of-use can enable future studies aimed at investigating TD-DOT applications.

Language: Английский

Citations

3
Special Section Guest Editorial: Thirty Years of Functional Near-Infrared Spectroscopy DOI Creative Commons
David Highton, David A. Boas,

Yasuyo Minagawa

et al.

Neurophotonics, Journal Year: 2023, Volume and Issue: 10(02)

Published: July 6, 2023

Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive optical technique that measures cerebral hemodynamics across multiple regions of interest, and thereby characterises brain functional activation. Since its first description in 1993, fNIRS has undergone substantial developments hardware, analysis techniques, applications. Thirty years later, this significantly enchancing our understanding diverse areas neuroscience research such as neurodevelopment, cognitive neuroscience, psychiatric disorders, neurodegenerative conditions, injury management intensive care settings. This special issue outlines the latest progress instrumentation techniques showcases some applications within expanding field over past decade.

Language: Английский

Citations

8
Neuromonitoring practices for neonates with congenital heart disease: a scoping review DOI Creative Commons
Andrea C. Pardo, Melisa Carrasco, Pia Wintermark

et al.

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 25, 2024

Abstract Neonates with congenital heart disease (CHD) are at risk for adverse neurodevelopmental outcomes. This scoping review summarizes neuromonitoring methods in neonates CHD. We identified 84 studies investigating the use of near-infrared spectroscopy (NIRS) ( n = 37), electroencephalography (EEG) 20), amplitude-integrated (aEEG) 10), transcranial Doppler sonography (TCD) 6), and multimodal monitoring 11). NIRS was used to evaluate cerebral oxygenation, identify thresholds events intensive care unit (ICU), EEG utilized screen seizures predict Studies aEEG have focused on characterizing background patterns, detecting seizures, TCD correlation short-term clinical Multimodal characterized physiologic dynamics. Most were performed single centers, had a limited number (range 3–183), demonstrated variability practices, lacked standardized approaches testing. areas improvement future research: (1) large multicenter developmental correlates practices; (2) guidelines standardize testing methodologies; (3) research address geographic variation resource utilization; (4) integration synchronization monitoring; (5) establish framework techniques across diverse settings. Impact literature regarding practices (CHD). The identification low oxygenation may be ICU or Postoperative continuous screening subclinical status epilepticus, allow early appropriate therapy. Future should focus enrolling larger cohorts CHD this population. utilize standard assessments intervals.

Language: Английский

Citations

2
Feasibility of noninvasive near-infrared spectroscopy monitoring in predicting the prognosis of spontaneous intracerebral hemorrhage DOI Creative Commons

Zhen Sun,

Jing Liu,

Kunpeng Wang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Objective This study aimed to assess the impact of multimodal monitoring on predicting prognosis patients with spontaneous intracerebral hemorrhage (SICH) and examine feasibility using noninvasive near-infrared spectroscopy (NIRS) for clinical prognosis. Methods Clinical data 38 SICH who underwent surgery in Department Neurosurgery Shaanxi Provincial People’s Hospital from May 2022 December were retrospectively analyzed. The categorized into two groups based Glasgow Outcome Scale (GOS) 3 months after operation: poor outcome group (GOSI-III) good (GOSIV V). Multimodal included invasive intracranial pressure (ICP), brain temperature (BT), internal jugular venous oxygen saturation (SjvO 2 ), NIRS. NIRS comprised assessment tissue (StO blood volume index (BVI), hemoglobin (THI). prognostic differences between compared. predictive values evaluated receiver operating characteristic (ROC) curve area under (AUC). Results ICP, BT, BVI, THI lower than those group. SjvO StO a higher Conclusion levels , reflect changes function cerebral flow significantly correlate SICH. has high utility assessing

Language: Английский

Citations

1
Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients? DOI Creative Commons

Olivia Kline,

Karthik Vishwanath,

Boyd Colbrunn

et al.

Journal of Biomedical Optics, Journal Year: 2024, Volume and Issue: 29(03)

Published: March 12, 2024

SignificanceShuntodynia is patient reported pain at the site of implanted ventriculoperitoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement a chronic and prevalent standard care treatment requires lifetime management. Shuntodynia subjective measure dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in clinic.AimPediatric subjects were recruited for optical sensing during routine clinical follow-up visits, post-VP implantations. Acquired signals translated into skin-hemodynamic signatures compared between that shuntodynia versus those did not.ApproachDiffuse reflectance (DRS) measurements collected 450 700 nm using single-channel fiber-optical probe from (N=35) patients. Multiple spectra obtained by attending physician regions both proximal distal VP sites matched contralateral each subject. processed quantitatively functional endpoints. A two-way, repeated measures analysis variance was assess whether which variables statistically separable, across with without.ResultsAnalyses indicated intrapatient differences vascular oxygen saturation measured relative scar or significantly lower group. We also find total hemoglobin concentrations lowest other reporting pain. These findings suggest arises scalp around shunts may caused due hypoxia inflammation.ConclusionsOptically derived hemodynamic different presenting without. DRS provide viable mode bedside monitoring management assessment shuntodynia.

Language: Английский

Citations

0
Full Wavelength Selection and Deep Spectra Feature Extraction Network for Near-Infrared Spectroscopy Quantitative Analysis DOI
Jinlong Liu, Xiaoli Luan, Fei Liu

et al.

2022 IEEE 11th Data Driven Control and Learning Systems Conference (DDCLS), Journal Year: 2024, Volume and Issue: unknown, P. 1350 - 1355

Published: May 17, 2024

Language: Английский

Citations

0
Microcirculation: Current Perspective in Diagnostics, Imaging, and Clinical Applications DOI Open Access
Uğur Aksu,

Berna Yavuz-Aksu,

Nandu Goswami

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6762 - 6762

Published: Nov. 10, 2024

This review discusses the pivotal role of microcirculation in maintaining tissue oxygenation and waste removal highlights its significance various pathological conditions. It delves into cellular mechanisms underlying hemodynamic coherence, elucidating roles endothelium, glycocalyx, erythrocytes sustaining microcirculatory integrity. Furthermore, gives comprehensive information about changes observed cardiac surgery, sepsis, shock, COVID-19 disease. Through exploration, underscores intricate relationship between microcirculation, disease states, clinical outcomes, emphasizing importance understanding monitoring microvascular dynamics critical care settings.

Language: Английский

Citations

0
DIAGNOSTIC SIGNIFICANCE OF THE NEAR-INFRARED SPECTROSCOPY IN THE PREVENTION OF CEREBRAL INJURY DURING SURGICAL CORRECTION OF CONGENITAL HEART DEFECTS IN CHILDREN DOI
А. А. Михайлова, A. A. Ivkin, E. V. Grigoryev

et al.

Complex Issues of Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 13(4S), P. 241 - 253

Published: Dec. 28, 2024

Highlights With the recent advancement in cardiopulmonary bypass techniques pediatric cardiac surgery, issue of organ protection during surgery is becoming more urgent, particular cerebral turning into one most important parts patient management. The aim this literature review to determine role near-infrared spectroscopy among a variety for monitoring function. Abstract Near-infrared evaluates regional tissue perfusion and oxygenation brain tissues with (CPB). Data on correlation laboratory markers injury indicators oximetry children make it possible create effective strategies prevention postoperative cognitive dysfunction as part comprehensive intraoperative assessment patient's condition. article was analyze effectiveness surgical correction congenital heart defects CPB children. search Russian English publications (up 10 years old) performed using following databases: Web Science, PubMed, E-library. keywords were: “organ protection”, “congenital defects”, “children”, “cardiopulmonary bypass”, “near-infrared spectroscopy”. Publications that did not meet specified criteria were excluded from analysis. findings substantiate use assess purpose defects. various types has been shown. routine technique assessing CPB. data presented demonstrate relationship between Further research needed explore prospects described method protection.

Language: Английский

Citations

0