Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Astrocytes play a pivotal role in the inflammatory response triggered by traumatic brain injury (TBI). They are not only involved initial following but also significantly contribute to Astrocyte activation and inflammasome release key processes pathophysiology of TBI, affecting progression secondary long-term outcomes. This comprehensive review explores complex triggering mechanisms astrocyte intricate pathways controlling inflammasomes from activated astrocytes, subsequent neuroinflammatory cascade its multifaceted roles after injury. The exploration these deepens our understanding highlights potential astrocytes as critical therapeutic targets for TBI interventions. We then evaluate cutting-edge research aimed at targeted approaches modulate pro-inflammatory discuss emerging pharmacological interventions their efficacy preclinical models. Given that there has yet be relevant elucidating specific intracellular targeting substances, this aims provide nuanced astrocyte-mediated neuroinflammation elucidate promising avenues could fundamentally change management improve patient development neurological sequelae. By releasing variety cytokines chemokines, regulate neuroinflammation, thereby influencing survival function surrounding cells. In recent years, researchers have concentrated efforts on signaling crosstalk between other cells under various conditions, while exploring paper which produce mediators during acute phase post-TBI, including signaling, blood-brain barrier integrity, neuronal protection. Additionally, we current clinical intervention strategies mitigate damage enhance recovery TBI. Finally, explore feasibility pharmacologically assessing activity post-TBI biomarker predicting acute-phase changes.

Language: Английский