Harnessing exosomes for targeted drug delivery systems to combat brain cancer DOI Creative Commons

Abdullah E Basyoni,

Amira Atta,

Maha M. Salem

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Abstract Brain cancer remains a significant challenge in the field of oncology, primarily because its aggressive nature and limited treatment options available. Conventional therapies often fall short effectively targeting tumor cells, while sparing healthy brain tissue from collateral damage. However, exosomes are now recognized as promising nanocarriers for targeted drug delivery. These naturally occurring extracellular vesicles can cross blood–brain barrier selectively interact with cells. Utilizing delivery vehicles offers novel approach potential therapy. By encapsulating therapeutic agents within exosomes, drugs be specifically to maximizing their impact whilst minimizing damage tissue. Furthermore, modified display molecules that recognize bind further enhancing precision efficacy. While exosome-based show potential, scalability, purification, clinical application challenges remain. The scalability exosome production, modification techniques hurdle must overcome translation. Additionally, intricate interactions between microenvironment necessitate research optimize outcomes. review explores applications future perspectives advancing treatment.

Language: Английский

Harnessing exosomes for targeted drug delivery systems to combat brain cancer DOI Creative Commons

Abdullah E Basyoni,

Amira Atta,

Maha M. Salem

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Abstract Brain cancer remains a significant challenge in the field of oncology, primarily because its aggressive nature and limited treatment options available. Conventional therapies often fall short effectively targeting tumor cells, while sparing healthy brain tissue from collateral damage. However, exosomes are now recognized as promising nanocarriers for targeted drug delivery. These naturally occurring extracellular vesicles can cross blood–brain barrier selectively interact with cells. Utilizing delivery vehicles offers novel approach potential therapy. By encapsulating therapeutic agents within exosomes, drugs be specifically to maximizing their impact whilst minimizing damage tissue. Furthermore, modified display molecules that recognize bind further enhancing precision efficacy. While exosome-based show potential, scalability, purification, clinical application challenges remain. The scalability exosome production, modification techniques hurdle must overcome translation. Additionally, intricate interactions between microenvironment necessitate research optimize outcomes. review explores applications future perspectives advancing treatment.

Language: Английский

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