Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss
Fundamental Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Irx3/5 Null Deletion in Mice Blocks Cochlea‐Saccule Segregation and Disrupts the Auditory Tonotopic Map
The Journal of Comparative Neurology,
Journal Year:
2024,
Volume and Issue:
532(12)
Published: Dec. 1, 2024
A
gene
cadre
orchestrates
the
normal
development
of
sensory
and
non-sensory
cells
in
inner
ear,
segregating
cochlea
with
a
distinct
tonotopic
sound
frequency
map,
similar
brain
projection,
five
vestibular
end-organs.
However,
role
genes
driving
ear
is
largely
unknown.
Here,
we
show
double
deletion
Iroquois
homeobox
3
5
transcription
factors
(Irx3/5
DKO)
leads
to
fusion
saccule
cochlear
base.
The
overlying
otoconia
tectorial
membranes
are
absent
Irx3/5
DKO
primary
auditory
neurons
project
fibers
both
hair
cells.
central
neuronal
projections
from
apex-base
contour
not
fully
segregated
into
dorsal
ventral
innervation
nucleus,
obliterating
characteristic
map.
Additionally,
reveals
pronounced
cochlear-apex-vestibular
"vestibular-cochlear"
nerve
(VCN)
bilateral
connection
that
less
noticeable
wild-type
control
mice.
Moreover,
incomplete
segregation
apex
base
expands
connect
nuclei.
results
suggest
mammalian
derived
lagena
reminiscent
sarcopterygians.
Thus,
Irx3
potential
evolutionary
branch-point
necessary
for
balance-sound
segregation,
which
fused
saccule-cochlea
organization.
Language: Английский
Introduction to the special issue on fish bioacoustics: Hearing and sound communication
The Journal of the Acoustical Society of America,
Journal Year:
2024,
Volume and Issue:
155(4), P. 2385 - 2391
Published: April 1, 2024
Fish
bioacoustics,
or
the
study
of
fish
hearing,
sound
production,
and
acoustic
communication,
was
discussed
as
early
Aristotle.
However,
questions
about
how
fishes
hear
were
not
really
addressed
until
20th
century.
Work
on
bioacoustics
grew
after
World
War
II
considerably
in
21st
century
since
investigators,
regulators,
others
realized
that
anthropogenic
(human-generated
sounds),
which
had
primarily
been
interest
to
workers
marine
mammals,
likely
have
a
major
impact
(as
well
aquatic
invertebrates).
Moreover,
passive
monitoring
fishes,
recording
sounds
field,
has
blossomed
noninvasive
technique
for
sampling
abundance,
distribution,
reproduction
various
sonic
fishes.
The
field
is
vital
invertebrates
make
up
portion
protein
eaten
by
signification
humans.
To
help
better
understand
engage
it
with
issues
sound,
this
special
issue
Journal
Acoustical
Society
America
(JASA)
brings
together
papers
explore
breadth
topic,
from
historical
perspective
latest
findings
Language: Английский