At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities

Translational research, Journal Year: 2021, Volume and Issue: 234, P. 58 - 73

Published: March 10, 2021

Language: Английский

---

The Role of Sleep in the Transition from Acute to Chronic Musculoskeletal Pain in Youth—A Narrative Review

Children, Journal Year: 2021, Volume and Issue: 8(3), P. 241 - 241

Published: March 20, 2021

Musculoskeletal pain is common in the general pediatric population and a challenge to youth, their parents, society. The majority of children experiencing musculoskeletal will recover; however, small subgroup youth develops chronic pain. There limited understanding factors that affect transition from acute youth. This review introduces sleep deficiency transition, exploring potential mediational or mechanistic role pathways this process, including interaction with sensory, psychological, social components highlighting new avenues for treatment. Biological mechanisms include increased production inflammatory mediators effect on hypothalamus-pituitary-adrenal (HPA) axis dopaminergic signaling. Psychological emotional-affective behavioral pain, negative impact daily activities coping strategies reward system, catastrophizing, fear pain-related anxiety, hypervigilance, isolation. Future longitudinal studies are needed elucidate these which may lead development treatment targets prevent transition.

Language: Английский

---

Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(11), P. 4777 - 4792

Published: Sept. 6, 2023

Abstract Opioid craving and relapse vulnerability is associated with severe persistent sleep circadian rhythm disruptions. Understanding the neurobiological underpinnings of rhythms opioid use disorder (OUD) may prove valuable for developing new treatments addiction. Previous work indicated molecular disruptions in human brain OUD, highlighting synaptic alterations dorsolateral prefrontal cortex (DLPFC) nucleus accumbens (NAc)—key regions involved cognition reward, heavily implicated pathophysiology OUD. To provide further insights into we used mass-spectrometry based proteomics to deeply profile protein expression bulk tissue synaptosome preparations from DLPFC NAc unaffected OUD subjects. We identified 55 differentially expressed (DE) proteins homogenates, 44 DE between In synaptosomes, 161 56 NAc, respectively, By comparing homogenate expression, enriched specifically synapses that were significantly altered both Across regions, subjects primarily glutamate, GABA, signaling. Using time-of-death (TOD) analyses, where TOD each subject as a time-point across 24-h cycle, able map circadian-related changes proteomes vesicle-mediated transport membrane trafficking platelet-derived growth factor receptor beta signaling DLPFC. Collectively, our findings lend support key

Language: Английский

---

Associations between adolescent sleep deficiency and prescription opioid misuse in adulthood

SLEEP, Journal Year: 2020, Volume and Issue: 44(3)

Published: Sept. 26, 2020

Abstract Study objectives The main aim of this study was to estimate the association between sleep deficiency in adolescence and subsequent prescription opioid misuse adulthood using United States nationally representative longitudinal data. Methods Self-reported data captured National Longitudinal Adolescent Adult Health at baseline (Wave 1; mean age = 16 years) 12 year follow-up 4; 29 years). Participants (n 12,213) reported on four measures during 1) lifetime 4). Associations adolescent adult were estimated multivariate logistic regression analysis controlling for sociodemographics, chronic pain, mental health, childhood adverse events, a history substance use. Results During adolescence, 59.2% participants deficiency. Prospectively, adolescents reporting not getting enough sleep, unrestful insomnia associated with an increased risk (adjusted odds ratios [OR] 1.2, p < 0.005 all three variables). Short duration misuse. Conclusion This is first longitudinally link as independent factor development Sleep could be driver crisis affecting young people States. Future studies should determine whether early targeted interventions may decrease high-risk patients prescribed opioids pain.

Language: Английский

---

The complexities of the sleep-pain relationship in adolescents: A critical review

Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 67, P. 101715 - 101715

Published: Nov. 12, 2022

Language: Английский

---