The interplay between the microbiota and opioid in the treatment of neuropathic pain

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 10, 2024

Neuropathic pain (NP) is characterized by its complex and multifactorial nature limited responses to opioid therapy; NP associated with risks of drug resistance, addiction, difficulty in treatment cessation, psychological disorders. Emerging research on gut microbiota their metabolites has demonstrated effectiveness alleviating augmenting opioid-based management, concurrently mitigating the adverse effects opioids. This review addresses following key points: (1) current advances challenges using opioids treat NP, (2) reciprocal benefits (3) interaction between microbiota, as well NP. Through various intricate mechanisms, influences onset progression ultimately enhancing efficacy management These insights pave way for further pragmatic clinical research, management.

Language: Английский

Ghrelin Modulates Voltage-Gated Ca²⁺Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons

Molecular Pharmacology, Journal Year: 2024, Volume and Issue: 106(5), P. 253 - 263

Published: Aug. 26, 2024

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic administration has previously been shown to increase gastric motility and emptying. While these effects are known be mediated by vagus nerve, cellular mechanism underlying remains unclear. Therefore, purpose of present study was investigate signaling which GHSR1a inhibits voltage-gated Ca

Language: Английский