Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Science, Journal Year: 2019, Volume and Issue: 366(6465), P. 628 - 631

Published: Oct. 31, 2019

Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related not known. We used accelerated neuroimaging measure physiological dynamics human discovered a coherent pattern oscillating electrophysiological, hemodynamic, CSF that appears during non-rapid eye movement sleep. Neural slow followed by hemodynamic oscillations, which turn coupled flow. These results demonstrate sleeping exhibits flow on macroscopic scale, interlinked with rhythms.

Language: Английский

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Glymphatic failure as a final common pathway to dementia

Science, Journal Year: 2020, Volume and Issue: 370(6512), P. 50 - 56

Published: Oct. 2, 2020

Sleep is evolutionarily conserved across all species, and impaired sleep a common trait of the diseased brain. quality decreases as we age, disruption regular architecture frequent antecedent to onset dementia in neurodegenerative diseases. The glymphatic system, which clears brain protein waste products, mostly active during sleep. Yet system degrades with suggesting causal relationship between disturbance symptomatic progression dementias. ties that bind sleep, aging, clearance, aggregation have shed new light on pathogenesis broad range diseases, for failure may constitute therapeutically targetable final pathway.

Language: Английский

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Perivascular spaces in the brain: anatomy, physiology and pathology

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 16(3), P. 137 - 153

Published: Feb. 24, 2020

Language: Английский

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Functional characterization of the dural sinuses as a neuroimmune interface

Cell, Journal Year: 2021, Volume and Issue: 184(4), P. 1000 - 1016.e27

Published: Jan. 27, 2021

Language: Английский

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Circadian control of brain glymphatic and lymphatic fluid flow

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 2, 2020

The glymphatic system is a network of perivascular spaces that promotes movement cerebrospinal fluid (CSF) into the brain and clearance metabolic waste. This transport supported by water channel aquaporin-4 (AQP4) localized to vascular endfeet astrocytes. more effective during sleep, but whether sleep timing function remains unknown. We here show influx exhibit endogenous, circadian rhythms peaking mid-rest phase mice. Drainage CSF from cisterna magna lymph nodes exhibits daily variation opposite influx, suggesting distribution throughout animal depends on time-of-day. polarization AQP4 highest rest loss eliminates day-night difference in both drainage nodes. conclude under control supports this rhythm.

Language: Английский

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The Brain’s Glymphatic System: Current Controversies

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(7), P. 458 - 466

Published: May 15, 2020

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within central nervous system (CNS). Imaging studies, as well manipulations transport, point to a key role glymphatic-lymphatic clearance amyloid-β and other proteins. As such, represents new target combating neurodegenerative diseases. Not unexpectedly, introduction plumbing brain has stirred controversies. This opinion article will highlight what we know about brain's transport systems, where experimental data are lacking, still debated.

Language: Английский

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Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

Neuron, Journal Year: 2019, Volume and Issue: 105(3), P. 549 - 561.e5

Published: Dec. 3, 2019

Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important process in brain health and diseases such as Alzheimer's disease (AD) cerebral amyloid angiopathy (CAA). However, the major driving force for clearance remains largely unknown. Here we used vivo two-photon microscopy awake head-fixed mice assess role spontaneous vasomotion paravascular clearance. Vasomotion correlated with fluorescent dextran from interstitial fluid. Increasing amplitude by means visually evoked vascular responses resulted increased rates visual cortex mice. Evoked reactivity was impaired CAA, which corresponded slower rates. Our findings suggest that low-frequency arteriolar oscillations drive solutes. Targeting naturally occurring patients CAA or AD may a promising early therapeutic option prevention Aβ accumulation brain.

Language: Английский

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Fluid transport in the brain

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 1025 - 1151

Published: May 5, 2021

The brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the is geared fully toward processing information and behaving, while homeostatic functions predominate during sleep. blood-brain barrier establishes stable environment that optimal for neuronal function, yet imposes physiological problem; transcapillary filtration forms extracellular fluid in other organs reduced to minimum brain. Consequently, depends on special [the cerebrospinal (CSF)] flushed into along perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined term glymphatic system, based dependency endfeet their adluminal expression of aquaporin-4 water channels facing CSF-filled spaces. Glymphatic clearance potentially harmful metabolic or protein waste products, such as amyloid-β, primarily active sleep, when drivers, cardiac cycle, respiration, slow vasomotion, together efficiently propel CSF inflow periarterial brain's space contains an abundance proteoglycans hyaluronan, which provide low-resistance hydraulic conduit rapidly can expand shrink sleep-wake cycle. system brain, meets requisites maintain homeostasis similar peripheral organs, considering blood-brain-barrier paths formation egress CSF.

Language: Английский

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Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

Trends in Molecular Medicine, Journal Year: 2020, Volume and Issue: 26(3), P. 285 - 295

Published: Jan. 18, 2020

Language: Английский

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The Glymphatic System: A Novel Component of Fundamental Neurobiology

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(37), P. 7698 - 7711

Published: Sept. 15, 2021

Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess and metabolic waste. The glymphatic system is analog in CNS. As such, plays a key role regulating directional interstitial movement, waste clearance, and, potentially, brain immunity. enables bulk CSF from subarachnoid space along periarterial spaces, where it mixes with within parenchyma before ultimately exiting via perivenous spaces. This review focuses on important questions about structure this system, why needs transport unexplored aspects transport. We provide evidence that astrocytes blood vessels determine shape perivascular space, controlling fluid. Glymphatic has potential to alter local as well global signaling molecules metabolites. also highlight for cross talk among cardiovascular gastrointestinal tract, system. Much remains be studied, but we propose glymphatic/lymphatic acts cornerstone between body.

Language: Английский

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