Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(9)
Published: Jan. 22, 2021
Development
of
enzyme
mimics
for
the
scavenging
excessive
mitochondrial
superoxide
(O2•-
)
can
serve
as
an
effective
strategy
in
treatment
many
diseases.
Here,
protein
reconstruction
technology
and
nanotechnology
is
taken
advantage
to
biomimetically
create
artificial
hybrid
nanozyme.
These
nanozymes
consist
ferritin-heavy-chain-based
scaffold
a
metal
nanoparticle
core
active
center.
This
cascade
nanozyme
possesses
dismutase-
catalase-like
activities
also
targets
mitochondria
by
overcoming
multiple
biological
barriers.
Using
cardiac
ischemia-reperfusion
animal
models,
protective
advantages
are
demonstrated
vivo
during
oxidative
injury
recovery
heart
functionality
following
infarction
via
systemic
delivery
localized
release
from
adhesive
hydrogels
(i.e.,
patch),
respectively.
study
illustrates
de
novo
design
development
provides
promising
therapeutic
option
alleviating
damage
regenerative
medicine.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(7)
Published: Jan. 12, 2021
Abstract
Mesenchymal
stem
cells
(MSCs)
have
been
widely
studied
as
a
versatile
cell
source
for
tissue
regeneration
and
remodeling
due
to
their
potent
bioactivity,
which
includes
modulation
of
inflammation
response,
macrophage
polarization
toward
proregenerative
lineage,
promotion
angiogenesis,
reduction
in
fibrosis.
This
review
focuses
on
profiling
the
effects
paracrine
signals
MSCs,
commonly
referred
secretome,
highlighting
various
engineering
approaches
tune
MSC
secretome.
Recent
advances
biomaterials‐based
therapeutic
strategies
delivery
MSCs
MSC‐derived
secretome
form
extracellular
vesicles
are
discussed,
along
with
advantages
challenges.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(10), P. 7455 - 7472
Published: Feb. 28, 2024
The
epithelial
mucosa
is
a
key
biological
barrier
faced
by
gastrointestinal,
intraoral,
intranasal,
ocular,
and
vaginal
drug
delivery.
Ligand-modified
nanoparticles
demonstrate
excellent
ability
on
this
process,
but
their
efficacy
diminished
the
formation
of
protein
coronas
(PCs)
when
they
interact
with
matrices.
PCs
are
broadly
implicated
in
affecting
fate
NPs
vivo
vitro,
yet
few
studies
have
investigated
formed
during
interactions
mucosa,
especially
mucus.
In
study,
we
constructed
transferrin
modified
(Tf-NPs)
as
model
explored
mechanisms
effects
that
had
subsequent
impact
transcellular
transport
Tf-NPs.
mucus-secreting
cells,
Tf-NPs
adsorbed
more
proteins
from
mucus
layers,
which
masked,
displaced,
dampened
active
targeting
Tf-NPs,
thereby
weakening
endocytosis
efficiencies.
mucus-free
intracellular
trafficking,
enhanced
transcytosis
related
functions.
Inspired
soft
artificial
biomimetic
membranes,
used
mucin
an
"active
PC"
to
precoat
(M@Tf-NPs),
limited
negative
impacts
"passive
PCs"
interface
improved
favorable
routes
endocytosis.
M@Tf-NPs
associated
endoplasmic
reticulum-Golgi
functions,
prompting
exocytosis.
summary,
shielded
against
absorption
also
could
be
employed
spear
break
through
barrier.
These
findings
offer
theoretical
foundation
design
platform
enhance
efficiency
oral-administered
nanomedicines.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(14)
Published: Feb. 2, 2022
Restoration
of
sufficient
blood
supply
for
the
treatment
ischemia
remains
a
significant
scientific
and
clinical
challenge.
Here,
cell-like
nanoparticle
delivery
technology
is
introduced
that
capable
recapitulating
multiple
cell
functions
spatiotemporal
triggering
vascular
regeneration.
Specifically,
copper-containing
protein
successfully
prepared
using
recombinant
scaffold
based
on
de
novo
design
strategy,
which
facilitates
timely
release
nitric
oxide
improved
accumulation
particles
within
ischemic
tissues.
Through
closely
mimicking
physiological
cues,
authors
demonstrate
benefits
bioactive
factors
secreted
from
hypoxic
stem
cells
promoting
angiogenesis.
Following
this
cell-mimicking
manner,
artificial
hybrid
nanosized
(Hynocell)
are
constructed
by
integrating
secretome
into
nanoparticles
with
surface
coatings
membranes
fused
protein.
The
Hynocell,
hybridized
different
cell-derived
components,
provides
synergistic
effects
targeting
tissues
regeneration
in
acute
hindlimb
myocardial
infarction
models.
This
study
offers
new
insights
utilization
nanotechnology
to
potentiate
development
cell-free
therapeutics.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(13)
Published: Jan. 30, 2023
Abstract
Despite
the
promise
in
whole‐tumor
cell
vaccines,
a
key
challenge
is
to
overcome
lack
of
costimulatory
signals.
Here,
agonistic‐antibody‐boosted
tumor
nanovaccines
are
reported
by
genetically
engineered
antibody‐anchored
membrane
(AAM)
technology,
capable
effectively
activating
pathways.
Specifically,
AAM
can
be
stably
constructed
following
genetic
engineering
membranes
with
anti‐CD40
single
chain
variable
fragment
(scFv),
an
agonistic
antibody
induce
The
versatilely
designed
and
obtained
based
on
scFv‐anchored
nanotechnology.
Following
vaccination,
nanovaccine
(Nano‐AAM/CD40)
significantly
facilitates
dendritic
maturation
CD40‐humanized
transgenic
mice
subsequent
adaptive
immune
responses.
Compared
membrane‐based
alone,
enhanced
antitumor
efficacy
both
“hot”
“cold”
models
Nano‐AAM/CD40
demonstrates
importance
antibodies
development
tumor‐cell‐based
vaccines.
To
expand
design
nanovaccines,
further
incorporation
lysates
into
conceptually
construct
cell‐like
results
boosted
responses
improved
against
malignant
tumors
inoculated
mice.
Overall,
this
technology
provides
versatile
components
checkpoints.
