Mitochondrial signal transduction

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1620 - 1653

Published: Nov. 1, 2022

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.

Language: Английский

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Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(4), P. 546 - 562

Published: April 26, 2023

Language: Английский

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ROS production by mitochondria: function or dysfunction?

Oncogene, Journal Year: 2023, Volume and Issue: 43(5), P. 295 - 303

Published: Dec. 11, 2023

Language: Английский

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Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: July 18, 2022

Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cells response to therapy-induced hostile environment are largely unknown. As central organelle for cellular energy supply, mitochondria can rapidly undergo dynamic changes integrate signaling pathways provide bioenergetic biosynthetic flexibility cells, which contributes multiple aspects tumor characteristics, including drug resistance. Therefore, targeting therapy overcoming has attracted increasing attention various types cancer. Multiple mitochondrial processes, dynamics, metabolism, apoptotic regulatory machinery, have been demonstrated be potential targets. However, recent insights into revealed complexity structure functions, elusive functions biology, inaccessibility mitochondria, posed challenges clinical application mitochondrial-based therapeutic strategies. discovery both novel mitochondria-targeting agents innovative approaches is urgently required. Here, we review most literature summarize molecular their intricate connection with In addition, an overview emerging strategies target effectively chemoresistance highlighted, emphasis on repositioning delivery approaches, may accelerate compounds therapy.

Language: Английский

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Nuclear-Mitochondrial Interactions

Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 427 - 427

Published: March 10, 2022

Mitochondria, the cell’s major energy producers, also act as signaling hubs, interacting with other organelles both directly and indirectly. Despite having its own circular genome, majority of mitochondrial proteins are encoded by nuclear DNA. To respond to changes in cell physiology, mitochondria must send signals nucleus, which can, turn, upregulate gene expression alter metabolism or initiate a stress response. This is known retrograde signaling. A variety stimuli pathways fall under umbrella. Mitochondrial dysfunction has already been shown have severe implications for human health. Disruption signaling, whether associated cellular environmental changes, may contribute pathological deficits. In this review, we discuss between examine possibility direct contacts, identify consequences an altered relationship.

Language: Английский

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Mitochondrial signalling and homeostasis: from cell biology to neurological disease

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(2), P. 137 - 152

Published: Jan. 10, 2023

Efforts to understand how mitochondrial dysfunction contributes neurodegeneration have primarily focussed on the role of mitochondria in neuronal energy metabolism. However, progress understanding etiological nature emerging functions has yielded new ideas about basis neurological disease. Studies aimed at deciphering signal through interorganellar contacts, vesicular trafficking, and metabolic transmission revealed that regulation immunometabolism, cell death, organelle dynamics, neuroimmune interplay are critical determinants neural health. Moreover, homeostatic mechanisms exist protect health turnover via nanoscale proteostasis lysosomal degradation become integrated within signalling pathways support plasticity stress responses nervous system. This review highlights these distinct converge influence contribute disease pathology.

Language: Английский

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Stay in touch with the endoplasmic reticulum

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(2), P. 230 - 257

Published: Jan. 4, 2024

Language: Английский

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Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 234, P. 108048 - 108048

Published: Nov. 28, 2021

Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess diverse central nervous system (CNS) pathologies in preclinical clinical studies. Many studies have shown that animal models human neurological neurodegenerative disease the condition, TSPO levels increase brain neuropil, this driven by infiltration peripheral inflammatory cells activation glial cells. Therefore, clear understanding dynamics cellular sources response critically important interpretation Positron Emission Tomography (PET) for pathophysiology CNS diseases. Within normal compartment, there are tissues such as choroid plexus, ependymal lining ventricles, vascular endothelial also express at even higher than However, paucity knowledge if these cell types respond diseased brain. These do provide background signal needs be accounted TSPO-PET imaging More recently, reports may expressed neurons adult expression increased neuronal activity. it essential study topic with great deal detail, methodological rigor, rule out alternative interpretations artifacts. High present outer mitochondrial membrane. Recent provided evidence its localization other compartments including plasma membrane perinuclear regions which define functions different from mitochondria. A greater subcellular infiltrating immune associated function(s) an additional layer information neurobiology. This review effort outline recent advances examine remaining questions require rigorous investigation.

Language: Английский

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Mitochondrial Metabolism in Carcinogenesis and Cancer Therapy

Cancers, Journal Year: 2021, Volume and Issue: 13(13), P. 3311 - 3311

Published: July 1, 2021

Carcinogenesis is a multi-step process that refers to transformation of normal cell into tumoral neoplastic cell. The mechanisms promote tumor initiation, promotion and progression are varied, complex remain be understood. Studies have highlighted the involvement oncogenic mutations, genomic instability epigenetic alterations as well metabolic reprogramming, in different processes oncogenesis. However, underlying still clarified. Mitochondria central organelles at crossroad various energetic metabolisms. In addition their pivotal roles bioenergetic metabolism, they control redox homeostasis, biosynthesis macromolecules apoptotic signals, all which linked carcinogenesis. present review, we discuss how mitochondria contribute initiation carcinogenesis through gene mutations production oncometabolites, reprogramming mitochondrial dynamics. Finally, metabolism promising target for development novel therapeutic strategies.

Language: Английский

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Mitochondrial and metabolic alterations in cancer cells

European Journal of Cell Biology, Journal Year: 2022, Volume and Issue: 101(3), P. 151225 - 151225

Published: April 13, 2022

Metabolic alterations have been observed in many cancer types. The deregulated metabolism has thus become an emerging hallmark of the disease, where is frequently rewired to aerobic glycolysis. This led concept "metabolic reprogramming", which therefore extensively studied. Over years, it characterized enhancement glycolysis, key mutations some enzymes TCA cycle, and increased glucose uptake, are used by cells achieve a phenotype" useful gain proliferation advantage. Many studies highlighted detail signaling pathways molecular mechanisms responsible for glycolytic switch. However, glycolysis not only metabolic process that rely on. Oxidative Phosphorylation (OXPHOS), gluconeogenesis or beta-oxidation fatty acids (FAO) may be involved development progression several tumors. In cases, these metabolisms even more crucial than tumor survival. review will focus on contribution survival cancers. We also analyze balance between processes regulated, as well therapeutical approaches can derive from their study.

Language: Английский

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