Neurobiology of Learning and Memory, Journal Year: 2022, Volume and Issue: 195, P. 107683 - 107683
Published: Sept. 26, 2022
Language: Английский
Frontiers in Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 16
Published: July 1, 2022
Fear and anxiety-based disorders are highly debilitating among the most prevalent psychiatric disorders. These associated with abnormal network oscillations in brain, yet a comprehensive understanding of role regulation aversively motivated behavior is lacking. In this review, we examine oscillatory correlates fear anxiety particular focus on rhythms theta gamma-range. First, describe neural their link to function by detailing well-studied gamma spatial memory functions hippocampus. We then how act synchronize brain structures guide adaptive anxiety-like behavior. short, that hippocampal integrate information motivationally salient from amygdala during states before routing via appropriate target regions, such as prefrontal cortex. Moreover, develop neocortical areas encoding memories, interregional synchronization reflects retrieval both recent remotely encoded memories. Finally, argue thalamic nucleus reuniens represents key node synchronizing prefrontal-hippocampal dynamics for episodic extinction memories
Language: Английский
Citations
23
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 18, 2024
Abstract Empathy enables understanding and sharing of others’ feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), cingulate (ACC), amygdala, inferior frontal gyrus (IFG). However, to date, precise spatio-temporal profiles empathic neural responses inter-regional communications remain elusive. Here, using intracranial electroencephalography, we investigated electrophysiological signatures vicarious pain perception. Others’ perception induced early increases in high-gamma activity IFG, beta power ACC, but decreased AI amygdala. Vicarious also altered beta-band-coordinated coupling between AI, as well increased modulation IFG amplitudes by phases amygdala/AI/ACC. We a necessary combination features decoding These spatio-temporally specific regional activities interactions within network suggest neurodynamic model human empathy.
Language: Английский
Citations
5
Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(10)
Published: Oct. 1, 2023
Commonly encountered nontraumatic, moderate noise is increasingly implicated in anxiety; however, the neural substrates underlying this process remain unclear.We investigated circuit mechanism through which chronic exposure to moderate-level causes anxiety-like behaviors.Mice were exposed chronic, white [85 decibel (dB) sound pressure level (SPL)], 4 h/d for wk induce behaviors, assessed by open field, elevated plus maze, light-dark box, and social interaction tests. Viral tracing, immunofluorescence confocal imaging, brain slice patch-clamp recordings used characterize projections from auditory regions lateral amygdala. Neuronal activities characterized vivo multielectrode fiber photometry awake mice. Optogenetics chemogenetics manipulate specific circuitry.Mice chronically (4 wk) (85 dB SPL, h/d) demonstrated greater neuronal activity amygdala (LA), LA played a critical role noise-induced behavior these model tracing showed that received monosynaptic medial geniculate body (MG) cortex (ACx). Optogenetic excitation of MG→LA or ACx→LA circuits acutely evoked whereas their chemogenetic inactivation abolished behavior. Moreover, mice more susceptible acute stress, with firing LA, even after withdrawal.Mice behavioral physiological differences compared controls. The mechanisms involved glutamatergic neurons MG ACx under exposure, ultimately promoted behaviors. Our findings support hypothesis nontraumatic pollution potentially serious but unrecognized public health concern. https://doi.org/10.1289/EHP12532.
Language: Английский
Citations
12
BJPsych Open, Journal Year: 2024, Volume and Issue: 10(2)
Published: March 1, 2024
Background Borderline personality disorder (BPD) is a severe psychiatric conceptualised as of emotion regulation. Emotion regulation has been linked to frontolimbic network comprising the dorsolateral prefrontal cortex and amygdala, which apparently synchronises its activity via oscillatory coupling in theta frequency range. Aims To analyse whether there are distinct differences frontal brain regions between individuals with BPD matched controls during by cognitive reappraisal. Method Electroencephalogram (EEG) recordings were performed 25 women diagnosed reappraisal task participants instructed downregulate negative emotions evoked aversive visual stimuli. Between- within-group time–frequency analyses conducted regulation-associated (3.5–8.5 Hz). Results Oscillatory differed Regulation-associated increases lower cohort compared controls. Functional connectivity analysis for changes band revealed multivariate interaction measure (MIM) increase persons Conclusions Our findings support notion alterations BPD, may be underlying core symptoms such deficits The results add growing body evidence altered dynamics populations, might investigated individualised treatment targets using non-invasive stimulation methods.
Language: Английский
Citations
4
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Summary Recent studies have shown that sensory rhythmic stimulation can enhance executive functions by synchronizing, entraining, oscillations within higher-order cortical networks. However, whether this entrainment extends to subcortical structures and shapes human behavior remains unclear. In a first experiment, we used intracranial EEG recordings in epileptic patients during visual search task. While neutral induced moderate entrainment, demonstrated 5 Hz negative-valence significantly entrain theta widespread task-related cortico-subcortical network, with increased synchrony the ventral stream, hippocampus, dorsolateral prefrontal cortex. second behavioral experiment healthy individuals, performance improved under both conditions, but memory for target images, assessed through an additional recognition task, was enhanced after negative stimulation. These findings unravel role of valence modulating brain activity behaviors pave way its further application clinical intervention.
Language: Английский
Citations
0
NeuroImage, Journal Year: 2025, Volume and Issue: 307, P. 121037 - 121037
Published: Jan. 17, 2025
Observational fear learning delineates the process by which individuals learn about potential threats through observing others' reactions. Prior research indicates that with high trait anxiety (HTA) manifest pronounced responses in direct scenarios. However, specific influence of on observational remains insufficiently explored. This study aimed to fill this gap examining 64 university students, divided equally between those HTA and low (LTA), selected from an initial pool 483 participants. Participants were subjected tasks, their behavioral responses, physiological reactions, brain activations recorded. Results demonstrated participants exhibited differentiated skin conductance threat safety stimuli during acquisition phase, notwithstanding prior assurances against shock delivery. Furthermore, test reported significantly elevated expectancy ratings for both types stimuli, contrast LTA counterparts. Neuroimaging data, derived via functional near-infrared spectroscopy (fNIRS) revealed heightened medial prefrontal cortex activation when directly facing threats. systematically explores learning, uncovering exhibit excessive responses. These findings highlight critical role as a significant risk factor development disorders.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 12, 2025
Objective To investigate the quantitative characteristics and major subtypes of local structural connectomes for medial temporal lobe (MTL) parcellations. Methods The Q-Space Diffeomorphic Reconstruction (QSDR) method was used to track white matter fibers ROIs within MTL based on integrating high-resolution T1 MR imaging diffusion 100 adult Chinese individuals. Graph theoretical analysis employed construct connectome models acquire network parameters. These connectivity matrices these were classified into undergoing hierarchical clustering. Results (1) In brain connectomes, overall features exhibited a low characteristic path length paired with moderate high global efficiency, suggesting effectiveness construction. amygdala longer weaker efficiency than ipsilateral hippocampus parahippocampal connectomes. (2) hubs dispersed across ventral frontal, olfactory area, limbic, parietal regions subcortical nuclei, hippocampal mainly situated parietal, regions. distribution resembled but lacking interhemispheric connections nuclei. (3) each ROI by clustering, bilateral amygdala-prefrontal connectome; amygdala-ipsilateral or contralateral limbic amygdala-posterior connectome. primarily included hippocampus-ipsilateral anterior temporal-hippocampus-ventral temporal-occipital in domain hemisphere. resemblances those hippocampus. Conclusion We have constructed parcellations acquired parameters delineate through graph theory analysis. can be different subtypes, which closely related functional connectivity.
Language: Английский
Citations
0
Epilepsia, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Objective Recent studies highlight the amygdala's crucial role in temporal lobe epilepsy (TLE), particularly magnetic resonance imaging‐negative cases and new TLE subtypes with structural amygdala changes. This study aims to investigate electrophysiological properties connectivity patterns of amygdaloid complex patients using stereoelectroencephalography (SEEG). Methods From March 2020 December 2023, we collected data from nine drug‐resistant who underwent SEEG dual trajectories: dorsal (DA) targeting medial central nuclei, ventral (VA) basal lateral nuclei. We analyzed interictal ictal activities, focusing on power spectral density, epileptiform discharges (IEDs), coherence between DA VA regions ipsilateral temporal–limbic network, including hippocampus, superior gyrus, entorhinal cortex, fusiform orbitofrontal pole, insula. Results IEDs were significantly higher DA, epileptogenic zones involving amygdala. identified frequency‐dependent cortical areas interest during activity. The exhibited limbic network a greater number seizures, hippocampal head, pole delta theta frequencies. In contrast, was mainly confined hippocampus high‐gamma frequency ranges. Significance Our findings reveal distinct functional potentially divergent roles TLE. These insights could refine intracranial sampling protocols complex, guiding more precise strategies for resection neuromodulation patients.
Language: Английский
Citations
0
NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121161 - 121161
Published: March 1, 2025
Revealing the neurophysiological mechanisms underlying pain empathy has profound implications for understanding of social emotions and regulation. This study aimed to elucidate by which modulates individual experiences, focusing on two primary questions: When individuals empathize with pain, do they attend more emotional content associated or nociceptive experience itself? How does lexical labeling modulate negative affect during empathy? In this EEG study, we employed a paradigm divided into labeling, tool distinguish from stimuli. We collected data 39 participants analyzed their components frequency-specific brain activity across experimental conditions. Cross-frequency coupling analyses were conducted uncover responses. Our findings revealed that compared effectively reduces empathy. was evidenced decreased amplitude P300 component lower theta-band within prefrontal cortex, predominantly later stages labeling. Additionally, enhanced theta-gamma phase-amplitude coupling, theta phase modulation in posterior parietal sensorimotor cortices influencing gamma-band activity. These results suggest that, empathy, allocate greater attentional cognitive resources aspects pain. Thus, implicit regulation involves coordinated interactions multiple regions.
Language: Английский
Citations
0
NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121164 - 121164
Published: March 1, 2025
The amygdala exhibits distinct different activity patterns to threat and safety stimuli. Animal studies have demonstrated that the fear (i.e., threat) extinction safety) memory are encoded by its interaction with ventromedial prefrontal cortex (vmPFC). Recent in both animals humans suggest inter-regional between vmPFC can be supported theta oscillations during processing. However, mechanism which human vmPFC-amygdala pathway dynamically supports neural representations of same stimulus remains elusive, as it alternatively reflects situations. To investigate this phenomenon, we conducted intracranial EEG recordings drug-resistant epilepsy patients (n = 8) implanted depth electrodes who performed a conditioning task. This task was designed fixed structure whereby specific CS+ could either safe (never paired US) or threatening (possibly based on an implicit rule acquisition. Our findings showed embodying potential information accompanied increased activities acquisition early extinction. Furthermore, learning associated enhanced theta-related direction from amygdala. study provided directly electrophysiological evidence supporting dynamic oscillatory modulation amygdala-vmPFC circuit, suggests processing depends inputs
Language: Английский
Citations
0