The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques DOI Open Access
Amber Howell, Shaun Warrington, Clara Fonteneau

et al.

Published: Feb. 29, 2024

Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences in extent their To address this knowledge gap, we used diffusion magnetic resonance imaging (dMRI) perform brain-wide probabilistic tractography for 828 healthy adults from Human Connectome Project. We then developed framework quantify spatial each area’s Additionally, leveraged resting-state functional MRI, myelin, human neural gene expression data test thalamus varied along hierarchy. Our results revealed two cortico-thalamic motifs: 1) sensorimotor motif characterized by focal targeting posterolateral associated with fast, feed-forward flow; 2) an associative diffuse anteromedial slow, feed-back These findings were consistent across subjects also observed macaques, indicating cross-species generalizability. Overall, our study demonstrates association support functionally-distinct

Language: Английский

Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

et al.

Nature, Journal Year: 2024, Volume and Issue: 633(8029), P. 398 - 406

Published: Aug. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Language: Английский

Citations

17
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity DOI Creative Commons
Wanling Peng, Xiaotong Liu, Guofen Ma

et al.

Cell Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Feb. 7, 2023

Astrocytes play a crucial role in regulating sleep-wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple lines of evidence supporting that modulation the behavior by astrocyte Ca2+ activity could occur without signaling. In basal forebrain brainstem, two brain regions are known essential for regulation, chemogenetically-induced elevation significantly modulated cycle. Although level positively correlated with amount extracellular adenosine, as revealed genetically encoded sensor, found no detectable change after suppressing elevation, transgenic mice lacking one major ATP-adenosine conversion enzymes showed similar Ca2+-induced sleep modulation. Furthermore, dependent primarily on local neuronal activity, causing region-specific regulation Thus, neural activity-dependent regulate independent

Language: Английский

Citations

36
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex DOI Creative Commons
Alex T. Piet,

Nick Ponvert,

Douglas R. Ollerenshaw

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(11), P. 1876 - 1890.e4

Published: March 5, 2024

In complex environments, animals can adopt diverse strategies to find rewards. How distinct differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize behavioral used by mice during a visual change detection task. Using dynamic logistic regression model, that individual use mixtures of comparison strategy statistical timing strategy. Separately, also have periods task engagement disengagement. Two-photon calcium imaging shows large strategy-dependent differences in neural activity excitatory, Sst inhibitory, Vip inhibitory cells response both image changes omissions. contrast, has limited effects population activity. diversity correlates be understood parsimoniously as increased activation strategy, which facilitates task-appropriate responses.

Language: Английский

Citations

10
Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells DOI Creative Commons
Leena A. Ibrahim, Shuhan Huang, Marian Fernández-Otero

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(21), P. 3473 - 3485.e5

Published: Sept. 2, 2021

Language: Английский

Citations

47
VIP-expressing interneurons in the anterior insular cortex contribute to sensory processing to regulate adaptive behavior DOI Creative Commons
Arnau Ramos-Prats, Enrica Paradiso, Federico Castaldi

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 39(9), P. 110893 - 110893

Published: May 1, 2022

Adaptive behavior critically depends on the detection of behaviorally relevant stimuli. The anterior insular cortex (aIC) has long been proposed as a key player in representation and integration sensory stimuli, implicated wide variety cognitive emotional functions. However, to date, little is known about contribution aIC interneurons processing. By using combination whole-brain connectivity tracing, imaging neural calcium dynamics, optogenetic modulation freely moving mice across different experimental paradigms, such fear conditioning social preference, we describe here role for vasoactive intestinal polypeptide-expressing (VIP+) mediating adaptive behaviors. Our findings enlighten VIP+ processing, showing that they are anatomically connected range sensory-related brain areas respond stimuli independent task modality.

Language: Английский

Citations

23
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(2), P. 184 - 200

Published: Oct. 31, 2023

Language: Английский

Citations

15
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Open Access

Shohei Furutachi,

Alexis D. Franklin, Thomas D. Mrsic‐Flogel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance error signals for various neural computations across multiple regions, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory required generating sensory errors in mouse primary visual cortex (V1). Using calcium imaging with optogenetic manipulations mice traverse familiar virtual environment, show that violation animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction specifically amplify input, rather than representing non-specific surprise or difference signal how input deviates from predictions. Selective amplification implemented cooperative mechanism requiring thalamic pulvinar, cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing (SOM) interneurons gate excitatory pulvinar V1, resulting pulvinar-driven response-amplification stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Language: Английский

Citations

13
Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex DOI Creative Commons
Yuxiao Li, Miao Ren,

Bimin Liu

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 15, 2025

The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent efferent connectivity of RSP essential for comprehending underlying mechanisms its functions. Here, via viral tracing fluorescence micro-optical sectioning tomography (fMOST), we systematically investigated anatomical organisation upstream downstream circuits glutamatergic GABAergic neurons dorsal ventral RSP. cortical connections show laminar which input are distributed more deeper layers cortex. Although different types have similar circuits, bidirectional hippocampus, whereas only unidirectional connections. Moreover, receive inputs from primary sensory than prefrontal association preferred such exhibits spatially topological visual lateral thalamus. systematic study on long-range across cell may provide useful information future revealing working mechanisms. Dissection mouse intermediate reveals subregions.

Language: Английский

Citations

0
Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse DOI Creative Commons
Miao Ren, Yuxiao Li, Tao Jiang

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract INTRODUCTION Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, mechanisms underlying AD‐associated changes in long‐range circuits remain poorly understood. METHODS In this study, we used viral tracing and fluorescence micro‐optical sectioning tomography (fMOST) imaging investigate whole‐brain input circuit of frontal cortex 5×FAD mice. RESULTS Pathological axonal degeneration was widely observed upstream regions, including cortex, hippocampus, thalamus, across all AD brains examined. The proportion neurons projecting parvalbumin‐expressing neurons, compared those somatostatin‐expressing decreased hippocampus basal forebrain. This decline closely related mouse age cell type presynaptic neurons. DISCUSSION study demonstrates selective vulnerability prelimbic area at mesoscopic level, thereby enhancing our understanding architecture brain. Highlights We with single‐cell resolution generate brain‐wide maps model. pathological proportions showed relevance age, distribution, Compared body dendrites medial prefrontal structure are more extensive.

Language: Английский

Citations

0
Deciphering neuronal variability across states reveals dynamic sensory encoding DOI Creative Commons
Shailaja Akella, Peter Ledochowitsch, Joshua H. Siegle

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Language: Английский

Citations

0