Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 439 - 464

Published: May 13, 2023

Language: Английский

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Advanced drug delivery system against ischemic stroke

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 344, P. 173 - 201

Published: March 4, 2022

Language: Английский

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Surface Engineering of Central Venous Catheters via Combination of Antibacterial Endothelium‐Mimicking Function and Fibrinolytic Activity for Combating Blood Stream Infection and Thrombosis

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 11, 2023

Abstract Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration endothelium‐mimicking fibrinolytic functions. In proposal, lysine (Lys)/Cu 2+ ‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed robustly fabricated onto commercial using facile two‐step process. Initially, adhesive ene ‐functionalized dopamine covalently reacted with Lys simultaneously coordinated bactericidal Cu ions, leading to deposition PDA/Lys/Cu on through mussel foot protein inspired chemistry. Next, poly(sulfobetaine methacrylate) (pSB) brushes are grafted endow lubricant antifouling properties. final PDA/Lys/Cu‐SB coating, function achieved combining catalytic generation nitric oxide from chelated pSB brushes, which led significant prevention thrombosis, bacterial vivo. Furthermore, immobilized activity show remarkably enhanced long‐term anti‐thrombogenic properties evidenced vivo demonstrating capability lyse nascent clots. Therefore, developed provides promising solution combat infection.

Language: Английский

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Ultrasound-powered hydrogen peroxide-responsive Janus micromotors for targeted thrombolysis and recurrence inhibition

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149187 - 149187

Published: Jan. 29, 2024

Language: Английский

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Platelet‐inspired nanomedicine in hemostasis thrombosis and thromboinflammation

Journal of Thrombosis and Haemostasis, Journal Year: 2022, Volume and Issue: 20(7), P. 1535 - 1549

Published: April 18, 2022

Platelets are anucleate cell-fragments derived predominantly from megakaryocytes in the bone marrow and released blood circulation, with a normal count of 150 000-40 000 per μl lifespan approximately 10 days humans. A primary role platelets is to aid vascular injury site-specific clot formation stanch bleeding, termed hemostasis. render hemostasis by complex concert mechanisms involving platelet adhesion, activation aggregation, coagulation amplification, retraction. Additionally, secretome can influence kinetics morphology. Therefore, defects dysfunctions result bleeding complications. Current treatment for such complications involve prophylactic or emergency transfusion platelets. However, logistics constantly suffer limited donor availability, challenges portability storage, high bacterial contamination risks, very short shelf life (~5 days). To address these issues, an exciting area research focusing on development microparticle- nanoparticle-based surrogate technologies that mimic various hemostatic On other hand, aberrant occurrence lead pathological manifestation thrombosis thromboinflammation. The treatments this focused inhibiting resolving formed clots. Here, platelet-inspired provide unique platforms disease-targeted drug delivery achieve therapeutic efficacy while avoiding systemic side-effects. This review will brief mechanistic insight into hemostasis, thromboinflammation, present current state-of-art design nanomedicine applications areas.

Language: Английский

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Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(43)

Published: Sept. 6, 2022

Microrobots are recognized as transformative solutions for drug delivery systems (DDSs) because they can navigate through the body to specific locations and enable targeted release. However, their realization is substantially limited by insufficient payload capacity, unavoidable leakage/deactivation, strict modification/stability criteria drugs. Natural puffballs possess fascinating features that highly desirable DDSs, including a large fruitbody storing spores, flexible protective cap, environmentally triggered release mechanisms. This report presents puffball-inspired microrobotic system which incorporates an internal chamber loading quantities spatial separation, near-infrared-responsive top-sealing layer offering strong protection on-demand These microrobots (PIMs) display tunable capacities up high concentrations enhanced with minimal leakage. Upon near-infrared laser irradiation, rapid efficiency achieved. The PIMs also demonstrate translational motion velocities, switchable modes, precise locomotion under rotating magnetic field. work provides proof-of-concept DDS combines superior capability of unique characteristics puffballs, thereby illustrating versatile avenue development new generation delivery.

Language: Английский

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Annexin V‐Modified Platelet‐Biomimetic Nanomedicine for Targeted Therapy of Acute Ischemic Stroke

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(16)

Published: June 16, 2022

Thromboembolic stroke is typically characterized by the activation of platelets, resulting in thrombus cerebral vascular system, leading to high morbidity and mortality globally. Intravenous thrombolysis tissue plasminogen activator (tPA) administration within 4.5 h from onset symptoms providing a standard therapeutic strategy for ischemic stroke, but this reagent simultaneously shows potential serious adverse effects, e.g., hemorrhagic transformation. Herein, novel delivery platform based on Annexin V platelet membrane developed tPA (APLT-PA) enhance targeting efficiency, reduce risk intracerebral hemorrhage acute stroke. After preparation extrusion subsequent insertion liposomes, APLT-PA exhibits efficiency activated vitro thrombosis site vivo, due binding phosphatidylserine (PS) proteins. One dose leads obvious significant improvement neurological function 7 days mice with photochemically induced This study provides novel, safe platelet-biomimetic nanomedicine precise thrombolytic treatment offers new theories design exploitation cell-mimetic diverse biomedical applications.

Language: Английский

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Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)

Published: March 31, 2023

Abstract Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels development advanced technologies for CVD diagnosis and treatment. Biomarker‐responsive nanomaterials are appealing therapeutic platforms that provide new horizons theranostics. In this review, recent advances in with endogenous biomarkers as stimuli or targets theranostics presented. First, categories involved comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet inflammation, osteopontin. The role these bridge‐building between then Next, biomedical applications responsive to treatment elaborated. Finally, challenges future research directions biomarker‐responsive also discussed. This review will scientific guidance facilitate clinical nanomaterials.

Language: Английский

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Redox-responsive peptide-based complex coacervates as delivery vehicles with controlled release of proteinous drugs

Communications Chemistry, Journal Year: 2023, Volume and Issue: 6(1)

Published: Nov. 7, 2023

Proteinous drugs are highly promising therapeutics to treat various diseases. However, they suffer from limited circulation times and severe off-target side effects. Inspired by active membraneless organelles capable of dynamic recruitment releasing specific proteins, here, we present the design coacervates as therapeutic protocells, made small metabolites (anionic molecules) simple arginine-rich peptides (cationic motif) through liquid-liquid phase separation. These complex demonstrate that their assembly disassembly can be regulated redox chemistry, which helps control release protein. A model proteinous drugs, tissue plasminogen activator (tPA), rapidly compartmentalize inside coacervates, formed conjugated with arginine-glycine-aspartic acid (RGD) motif (a fibrinogen-derived peptide sequence), show selective binding thrombus site thus enhance on-target efficacy tPA. Furthermore, burst tPA controlled redox-induced dissolution coacervates. Our proof-of-principle coacervate system provides insights into sequestration advanced drug delivery systems represents a step toward construction synthetic protocells for biomedical applications.

Language: Английский

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Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 338, P. 813 - 836

Published: Aug. 31, 2021

Language: Английский

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