Journal of Gastrointestinal Oncology,
Journal Year:
2023,
Volume and Issue:
14(2), P. 1064 - 1076
Published: April 1, 2023
A
significant
desmoplastic
response,
particularly
in
the
fibroblasts,
is
a
characteristic
of
pancreatic
ductal
adenocarcinoma
(PDAC).
Increasing
evidence
has
shown
that
cancer-associated
fibroblasts
(CAFs)
assist
tumor
development,
invasion,
and
metastasis
PDAC.
However,
CAFs-derived
molecular
determinants
regulate
mechanisms
PDAC
have
not
been
fully
characterized.The
expression
microRNA
125b-5p
(miR-125b-5p)
Pancreas
Cancer
(PC)
tissue
para-cancerous
normal
was
examined
using
Polymerase
Chain
Reaction
(PCR).
Cell
counting
kit-8
(CCK8),
wound
healing,
transwell
experiments
were
utilized
to
assess
effect
miR-125b-5p.
Using
cell
luciferase
activity
test
bioinformatics,
it
demonstrated
miR-125b-5p
may
bind
3'-untranslated
region
(3'-UTR)
adenomatous
polyposis
coli
(APC),
thereby
limiting
progression
cancer.PDAC
cells
are
prompted
proliferate,
undergo
epithelial-mesenchymal
transition
(EMT),
spread.
Importantly,
CAFs
release
exosomes
into
cells,
which
significantly
increase
level
those
cells.
Meanwhile,
cancer
lines
tissues
considerably
higher
expression.
MiR-125b-5p's
elevated
mechanically
suppresses
APC
accelerates
spread
cancer.Exosomes
released
by
promote
growth,
metastasis.
Exosomal
inhibition
offers
an
alternate
strategy
for
combating
basic
malady
Trends in cancer,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Tumorigenesis
ensues
within
a
heterogeneous
tissue
microenvironment
that
promotes
malignant
transformation,
metastasis
and
treatment
resistance.
A
major
feature
of
the
tumor
is
population
cancer-associated
fibroblasts
myeloid
cells
stiffen
extracellular
matrix.
The
heterogeneously
stiffened
matrix
in
turn
activates
cellular
mechanotransduction
creates
hypoxic
metabolically
hostile
microenvironment.
elevated
mechanosignaling
also
drive
aggression
by
fostering
cell
growth,
survival,
invasion,
compromising
antitumor
immunity,
expanding
cancer
stem
frequency,
increasing
mutational
burden,
which
promote
intratumor
heterogeneity.
Delineating
molecular
mechanisms
whereby
mechanics
regulate
these
phenotypes
should
help
to
clarify
basis
for
heterogeneity
identify
novel
therapeutic
targets
could
improve
patient
outcome.
Here,
we
discuss
role
driving
through
its
impact
on
EMBO Reports,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Disruption
of
the
circadian
clock
is
associated
with
development
inflammatory
bowel
disease
(IBD),
but
underlying
mechanisms
remain
unclear.
Here,
we
observe
that
mice
in
early
active
phase
(Zeitgeber
time
12,
ZT12)
are
more
tolerant
to
dextran
sodium
sulfate
(DSS)-induced
colitis,
compared
those
resting
(ZT0).
The
expression
gene
Bmal1
peaks
and
declines
phase.
knockout
intestinal
epithelium
reduces
DSS-induced
symptoms.
Mechanistically,
BMAL1
promotes
apoptosis
by
binding
apoptosis-related
genes,
including
Bax,
p53,
Bak1,
their
expression.
Intriguingly,
apoptotic
rhythms
homeostatic
epithelium,
while
deletion
cell
apoptosis.
Consistently,
reducing
REV-ERBα
agonist
SR9009
has
best
therapeutic
efficacy
against
colitis
at
ZT0.
Collectively,
our
data
demonstrate
Bmal1-centered
involved
injury
repair.
Stem Cells,
Journal Year:
2023,
Volume and Issue:
41(4), P. 319 - 327
Published: Feb. 6, 2023
Abstract
First
described
in
the
early
20th
century,
diurnal
oscillations
stem
cell
proliferation
exist
multiple
internal
epithelia,
including
gastrointestinal
tract,
and
epidermis.
In
mouse
epidermis,
3-
to
4-fold
more
cells
are
S-phase
during
night
than
day.
More
recent
work
showed
that
an
intact
circadian
clock
intrinsic
keratinocytes
is
required
for
these
epidermal
proliferation.
The
also
regulates
DNA
excision
repair
damage
response
ultraviolet
B
radiation.
During
skin
inflammation,
increased
suspended.
Here
we
discuss
possible
reasons
evolution
of
this
phenomenon.
We
argue
coordinates
intermediary
metabolism
cycle
minimize
accumulation
from
metabolism-generated
reactive
oxygen
species.
Circadian
disruption,
common
modern
society,
leads
asynchrony
between
cycle,
speculate
will
lead
oxidative
damage,
dysfunction
cells,
aging.
Journal of Gastrointestinal Oncology,
Journal Year:
2023,
Volume and Issue:
14(2), P. 1064 - 1076
Published: April 1, 2023
A
significant
desmoplastic
response,
particularly
in
the
fibroblasts,
is
a
characteristic
of
pancreatic
ductal
adenocarcinoma
(PDAC).
Increasing
evidence
has
shown
that
cancer-associated
fibroblasts
(CAFs)
assist
tumor
development,
invasion,
and
metastasis
PDAC.
However,
CAFs-derived
molecular
determinants
regulate
mechanisms
PDAC
have
not
been
fully
characterized.The
expression
microRNA
125b-5p
(miR-125b-5p)
Pancreas
Cancer
(PC)
tissue
para-cancerous
normal
was
examined
using
Polymerase
Chain
Reaction
(PCR).
Cell
counting
kit-8
(CCK8),
wound
healing,
transwell
experiments
were
utilized
to
assess
effect
miR-125b-5p.
Using
cell
luciferase
activity
test
bioinformatics,
it
demonstrated
miR-125b-5p
may
bind
3'-untranslated
region
(3'-UTR)
adenomatous
polyposis
coli
(APC),
thereby
limiting
progression
cancer.PDAC
cells
are
prompted
proliferate,
undergo
epithelial-mesenchymal
transition
(EMT),
spread.
Importantly,
CAFs
release
exosomes
into
cells,
which
significantly
increase
level
those
cells.
Meanwhile,
cancer
lines
tissues
considerably
higher
expression.
MiR-125b-5p's
elevated
mechanically
suppresses
APC
accelerates
spread
cancer.Exosomes
released
by
promote
growth,
metastasis.
Exosomal
inhibition
offers
an
alternate
strategy
for
combating
basic
malady
