Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility easy fabrication, their application reconstruction is often impeded by inadequate structural integrity biological functions. Graphene oxide (GO) emerged as a transformative additive, renowned its exceptional mechanical chemical properties, well ability to enhance the hydrogels. In this study, incorporation GO into chitosan (CS) investigated, achieving bioinspired with enhanced strength stability, which are crucial supporting regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) employed facilitate biomimetic mineralization hydrogels, critical process effective remodeling. This innovative composite hydrogel not only achieves but also exhibits osteogenic, pro‐angiogenic, antioxidant properties essential repair. novel method takes advantage distinctive GO, PNFs, biomass providing robust material solution potential significantly advance field tissue engineering.

Language: Английский

---

Exploring Present and Future Directions in Nano-Enhanced Optoelectronic Neuromodulation

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(9), P. 1398 - 1410

Published: April 23, 2024

ConspectusElectrical neuromodulation has achieved significant translational advancements, including the development of deep brain stimulators for managing neural disorders and vagus nerve seizure treatment. Optoelectronics, in contrast to wired electrical systems, offers leadless feature that guides multisite high spatiotemporal system targeting, ensuring specificity precision therapies known as "photoelectroceuticals". This Account provides a concise overview developments novel optoelectronic nanomaterials are engineered through innovative molecular, chemical, nanostructure designs facilitate interfacing with efficiency minimally invasive implantation.This outlines progress made both within our laboratory across broader scientific community, particular attention implications materials innovation strategies, studying bioelectrical activation methods, applications regenerative medicine. In innovation, we highlight nongenetic, biocompatible, approach spans various length scales, from single neurons tissues using nanosized particles monolithic membranes. Furthermore, discussion exposes critical unresolved questions field, mechanisms interaction at nanobio interface, cellular or tissue integration into existing networks modulation. addition, present challenges pressing needs long-term stability biocompatibility, scalability clinical applications, noninvasive monitoring control systems.In addressing field interfaces, particularly envisage promising strategic directions could significantly advance this burgeoning domain. involves deeper theoretical understanding nanobiointerfaces, where simulations experimental validations on how interact spatiotemporally biological systems crucial. The more durable is vital prolonged dynamic ability manipulate activity spatial resolution, paves way targeting individual specific circuits. Additionally, integrating these interfaces advanced possibly leveraging artificial intelligence machine learning algorithms programming dynamically responsive designs, ease implementation stimulation recording. These innovations hold potential introduce treatment modalities wide range neurological systemic disorders.

Language: Английский

---

In vitro and in vivo biocompatibility assessment of chalcogenide thermoelectrics as implants

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(28), P. 6847 - 6855

Published: Jan. 1, 2024

The ability of thermoelectric materials to generate electricity in response local temperature gradients makes them a potentially promising solution for the regulation cellular functions and reconstruction tissues. Biocompatibility implants is crucial attribute successful integration techniques biomedical applications. This work focuses on vitro vivo evaluation biocompatibility 12 typical chalcogenide thermoelectrics, which are composed biocompatible elements. Ag2Se, SnSe, Bi2Se3, Bi2Te2.88Se0.12 Bi2Te3, each with released ion concentration lower than 10 ppm extracts, exhibited favorable biocompatibility, including cell viability, adhesion, hemocompatibility, as observed initial assessments. Moreover, assessment, achieved by hematological histopathological analyses rat subcutaneous model, further substantiated possessing superior performance at room temperature. offers robust evidence promote Bi2Te3 potential biomaterials, establishing foundation their future applications biomedicine.

Language: Английский

---

Novel multi-functional microsphere scaffold with shape memory function for bone regeneration

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 163, P. 213958 - 213958

Published: July 14, 2024

Language: Английский

---

Engineering Stimuli‐Responsive Materials for Precision Medicine

Small, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 23, 2024

Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.

Language: Английский

---

Beyond Tissue replacement: The Emerging role of smart implants in healthcare

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100784 - 100784

Published: Aug. 29, 2023

Smart implants are increasingly used to treat various diseases, track patient status, and restore tissue organ function. These devices support internal organs, actively stimulate nerves, monitor essential functions. With continuous monitoring or stimulation, observation quality subsequent treatment can be improved. Additionally, using biodegradable entirely excreted implant materials eliminates the need for surgical removal, providing a patient-friendly solution. In this review, we classify smart discuss latest prototypes, materials, technologies employed in their creation. Our focus lies exploring medical beyond replacing an incorporating new functionality through sensors electronic circuits. We also examine advantages, opportunities, challenges of creating implantable that preserve all critical By presenting in-depth overview current state-of-the-art implants, shed light on persistent issues limitations while discussing potential avenues future advancements these devices.

Language: Английский

---

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

Soft Science, Journal Year: 2024, Volume and Issue: 4(2)

Published: April 23, 2024

Biodegradable electronics have revolutionized the field of medical devices by offering inherent advantages such as natural disintegration after a useful functional period, thereby eliminating need for removal surgery. This paradigm shift addresses challenges with long-term implantation, risks secondary surgeries, and potential complications, safer more patient-friendly approach to temporary implantable devices. review delves into dissolution kinetics materials strategies lifetime control providing comprehensive overview recent advancements in biodegradable electronics. Understanding is crucial meeting required applications, which varies based on application scope target diseases. The silicon metals form core discussion, focusing studies aimed at controlling rate enhancing properties. exploration extends ideas accelerating material degradation or initiating on-demand stable function. Additionally, compilation encapsulation layer enhances understanding how improve operation time Emphasis placed efforts adjust electronics, particularly applications.

Language: Английский

---

Remote actuation and on-demand activation of biomaterials pre-incorporated with physical cues for bone repair

Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4438 - 4461

Published: Jan. 1, 2024

The high incidence of bone defect-related diseases caused by trauma, infection, and tumor resection has greatly stimulated research in the field regeneration. Generally, healing is a long complicated process wherein manipulating biological activity interventional scaffolds to support long-term regeneration significant for treating bone-related diseases. It been reported that some physical cues can act as growth factor substitutes promote osteogenesis through continuous activation endogenous signaling pathways. This review focuses on latest progress repair remote actuation on-demand biomaterials pre-incorporated with (heat, electricity, magnetism). As an alternative method treat defects, show many advantages, including effectiveness, noninvasiveness, manipulation. First, we introduce impact different potential internal regulatory mechanisms. Subsequently, mediate various their respective characteristics are summarized. Additionally, challenges discussed, aiming provide new insights suggestions developing intelligent defects clinical translation.

Language: Английский

---

A Fractal‐Like Hierarchical Bionic Scaffold for Osseointegration

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Millions of patients each year are impacted by critical‐size bone tissue defects, the repair which involves inflammation and formation new tissue. In this study, a fractal biomimetic design for 3D‐printed scaffold that combined 3D printing with high‐energy plasma tantalum alloy fabrication, enabling easy production on an industrial scale is proposed. The bionic leverages principles geometry, employing self‐affine patterns random fractals to attain surface scaffolds. This approach aimed emulate dimensions observed in natural structures closely. While roughness implants plays critical role restoration outcomes, findings suggest incorporating dimension may hold greater significance than mere roughness. A rat skull‐defect model utilized assess osteogenic potential three scaffolds, photoacoustic technology first employed long‐term, situ monitoring physiological signals during process. Results from both cell animal experiments demonstrated scaffolds offer notable advantages over surface‐modified experimental results showed group manifested better bone‐promoting

Language: Английский

---

A biomimetic magnetically responsive scaffold with tunable and stable compression for dynamic 3D cell culture

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

---