Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection

Biomaterials, Journal Year: 2024, Volume and Issue: 307, P. 122532 - 122532

Published: March 14, 2024

Language: Английский

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An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 301 - 321

Published: Nov. 27, 2024

Language: Английский

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Low-Temperature Trigger Nitric Oxide Nanogenerators for Anti-biofilm and Wound Healing

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 512 - 528

Published: Feb. 13, 2024

Language: Английский

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Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6990 - 7010

Published: Feb. 22, 2024

The clinical treatment efficacy for implant-associated infections (IAIs), particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA), remains unsatisfactory, primarily due to the formation of biofilm barriers and resulting immunosuppressive microenvironment, leading chronicity recurrence IAIs. To address this challenge, we propose a light-induced immune enhancement strategy, synthesizing BSA@MnO2@Ce6@Van (BMCV). BMCV exhibits precise targeting adhesion S. biofilm-infected region, coupled with its capacity catalyze oxygen generation from H2O2 in hypoxic acidic microenvironment (BME), promoting oxygen-dependent photodynamic therapy while ensuring continuous release manganese ions. Notably, targeted can penetrate biofilms, producing ROS that degrade extracellular DNA, disrupting structure impairing barrier function, making it vulnerable infiltration elimination system. Furthermore, reactive species (ROS) around lyse aureus, triggering bacterium-like immunogenic cell death (ICD), releasing abundant costimulatory factors, facilitating recognition maturation antigen-presenting cells (APCs), activating adaptive immunity. Additionally, ions BME act as immunoadjuvants, further amplifying macrophage-mediated innate responses reversing immunologically cold an hot BME. We prove our synthesized elicits robust response vivo, effectively clearing primary IAIs inducing long-term memory prevent recurrence. Our study introduces potent immunomodulatory nanoplatform capable biofilm-induced biofilm-mediated protective barriers, offering promising immunotherapeutic strategy addressing challenging

Language: Английский

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Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1088 - 1112

Published: Jan. 29, 2024

Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.

Language: Английский

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Deep Red‐Light‐Mediated Nitric Oxide and Photodynamic Synergistic Antibacterial Therapy for the Treatment of Drug‐Resistant Bacterial Infections

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Infections caused by persistent, drug‐resistant bacteria pose significant challenges in inflammation treatment, often leading to severe morbidity and mortality. Herein, the photosensitizer rhodamine derivatives are selected as light‐trapping dye electron‐rich substituent N‐nitrosoaminophen nitric oxide (NO)‐releasing component develop a multifunctional (deep) red‐light activatable NO photocage/photodynamic prodrug for efficient treatment of wounds diabetic foot infections. The prodrug, RhB‐NO‐2 integrates antimicrobial photodynamic therapy (aPDT), sterilization, NO‐mediated anti‐inflammatory properties within small organic molecule is capable releasing generating Reactive oxygen species (ROS) when exposed red laser (660 nm). This strategy overcomes limitation using single photosensitizer, which inadequate eliminating bacteria. Additionally, it demonstrates that released from can interact with superoxide anions (O 2 •− ) generated PDT form more reactive oxidative agent, peroxynitrite (ONOO − ). These three components act synergistically enhance effects. Furthermore, inhibit NF‐κB pathway regulating expression toll‐like receptor (TRL2) tumor necrosis factor‐α (TNF‐α), thereby alleviating tissue inflammation. developed ， has potential expedite healing superficial infected offer promising approach treating ulcers (DFUs).

Language: Английский

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Light-activated nanoclusters with tunable ROS for wound infection treatment

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 385 - 399

Published: July 30, 2024

Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO

Language: Английский

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Direct and indirect approaches to red-shift photoactivated nitric oxide release

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 515, P. 215921 - 215921

Published: May 21, 2024

Nitric oxide (NO) is an important biochemical molecule that endogenously produced to act for instance as neurotransmitter, effect cell growth, or regulate the immune response. Therapeutic treatment with exogeneous NO difficult owing its gaseous and reactive nature and, not surprising, specific molecules deliver have been developed. Amongst various triggers deliberately release from these NO-releasing molecules, light most elegant allows a high degree of control over time location NO-release. For therapeutic applications, it necessary use long-wavelength light, preferably in red near infrared region, which challenging achieve. This review gives overview on approaches red-shift activation wavelength light-activated NO-release nitrosoamines, o-substituted nitroarenes, L-arginine, cupferron, nitrosyl metal complexes. While focusing single photon excitation events, direct mechanisms are covered well photoelectron transfer, energy chemiluminescence photothermal light-triggered oxidation pathways. each NO-releaser class, photochemical mechanism discussed, biological applications mentioned.

Language: Английский

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Heterostructure Nanozyme with Hyperthermia‐amplified Enzyme‐like Activity and Controlled Silver Release for Synergistic Antibacterial Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Heterostructure nanozymes as antibiotic-free antimicrobial agents exhibit great potential for multidrug-resistant (MDR) bacterial strains elimination. However, realization of heterostructure antimicrobials with enhanced interfacial interaction synergistically amplified antibacterial therapy is still a challenge. Herein, oxygen-vacancy-enriched glucose modified MoO

Language: Английский

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On-demand release of enrofloxacin-loaded chitosan oligosaccharide-oxidized hyaluronic acid composite nanogels for infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127248 - 127248

Published: Oct. 5, 2023

Language: Английский

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