Pt-Induced Sublattice Distortion Facilitates Enzyme Cascade Reactions for Eradicating Intracellularly Methicillin-Resistant Staphylococcus aureus and Enhancing Diabetic Wound Healing

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Metal oxide nanozymes hold significant potential in combating bacterial infections; however, their ordered crystal structures limit the enhancement of catalytic activity, posing challenges addressing clinical needs for eliminating intracellularly colonized bacteria. Here, we report development an integrated diagnostic-therapeutic microneedle patch incorporates Res@PtZ-Z nanozyme hybrid. consists a ZIF shell loaded with natural compound resveratrol (Res), encapsulating Pt-doped zinc (ZnO) core (PtZ). The Res component modulates charge distribution on and attenuates virulence, thereby promoting uptake by host cells. PtZ core, doped Pt4+ to induce sublattice distortion ZnO, exhibits oxidase-like, peroxidase-like, catalase-like activities. Under intracellular hypoxic conditions, cascade these enzyme-like activities ensures sustained generation reactive oxygen species (ROS), enabling robust antibacterial effects. Additionally, enables real-time infection monitoring oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) substrate produce distinct colorimetric response. This approach addresses both methicillin-resistant Staphylococcus aureus (MRSA) invasion persistence, contributing improved management wound healing.

Language: Английский

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Enhanced antibiofilm photodynamic therapy: Leveraging the slow photon effect for maximized efficacy with minimal photosensitizer and light doses

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102225 - 102225

Published: March 16, 2024

Language: Английский

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Material-based treatment strategies against intraosseous implant biofilm infection

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 39, P. 101764 - 101764

Published: June 30, 2024

Language: Английский

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Fast fabrication of “all-in-one” injectable hydrogels as antibiotic alternatives for enhanced bacterial inhibition and accelerating wound healing

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 26, 2024

Abstract Skin wound infection has become a notable medical threat. Herein, the polysaccharide-based injectable hydrogels with multifunctionality were developed by simple and fast gelation process not only to inactivate bacteria but also accelerate bacteria-infected healing. Sodium nitroprusside (SNP) loaded PCN-224 nanoparticles introduced into polymer matrix formed dynamic reversible coordinate bonds between Ag + carboxyl amino or hydroxyl groups on carboxymethyl chitosan (CMCS), hydrogen electrostatic interactions in fabricate SNP@PCN@Gel hydrogels. displayed interconnected porous structure, excellent self-healing capacity, low cytotoxicity, good blood compatibility, robust antibacterial activity. could produce reactive oxygen species (ROS) NO along Fe 2+ , showed long-term sustained release of thereby effectively killing synergistic photothermal (hyperthermia), photodynamic (ROS), chemodynamic (Fenton reaction), gas (NO) ion (Ag -NH 3 CMCS) therapy. Remarkably, significantly promoted granulation tissue formation, reepithelization, collagen deposition angiogenesis as well contraction Taken together, strategy represented general method engineer unprecedented photoactivatable “all-in-one” enhanced activity paved new way for development antibiotic alternatives dressing. Graphical abstract

Language: Английский

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Dual osmotic controlled release platform for antibiotics to overcome antimicrobial-resistant infections and promote wound healing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 627 - 642

Published: Sept. 23, 2024

Language: Английский

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