ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(12), P. 6824 - 6832
Published: Nov. 27, 2024
Cardiovascular
diseases
(CVDs)
are
a
major
global
health
concern,
highlighting
the
need
for
effective
diagnostic
tools.
Zinc
ions
(Zn2+)
play
role
in
CVDs,
but
their
detection
is
challenging.
This
study
presents
multifunctional
optical
sensor,
HD-Zn,
designed
to
detect
Zn2+
relation
CVDs.
We
developed
novel
fluorescence
probe,
by
conjugating
N,N-di(2-picolyl)ethylenediamine
(DPEN)
HD
via
an
amide
bond,
which
results
quenching
due
photoinduced
electron
transfer
(PeT).
Adding
significantly
increased
intensity
near-infrared
region
(NIR-I).
The
probe
showed
linear
response
varying
concentrations,
with
limit
of
9.8
nM,
appropriate
physiological
conditions.
Fluorescence
imaging
RAW264.7
macrophages
indicated
lower
intracellular
levels
foam
cells
compared
healthy
cells,
linked
CVDsprogression.
In
vivo
mouse
models
decreased
aorta
disease
progression.
Our
findings
confirm
that
HD-Zn
reliable
tool
measuring
plaques
and
demonstrate
its
biosafety
detecting
serum
urine,
offering
potential
clinical
applications
CVDs
diagnosis
monitoring.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(8), P. 960 - 960
Published: Aug. 7, 2024
Cardiovascular
diseases
(CVDs)
are
one
of
the
leading
causes
death
worldwide.
Despite
significant
advances
in
current
drug
therapies,
issues
such
as
poor
targeting
and
severe
side
effects
persist.
In
recent
years,
nanomedicine
has
been
extensively
applied
research
treatment
CVDs.
Among
these,
biomembrane-modified
biomimetic
nanodrug
delivery
systems
(BNDSs)
have
emerged
a
focus
due
to
their
unique
biocompatibility
efficient
capabilities.
By
modifying
with
biological
membranes,
BNDSs
can
effectively
reduce
recognition
clearance
by
immune
system,
enhance
circulation
time
vivo,
improve
targeting.
This
review
first
provides
an
overview
classification
pathological
mechanisms
CVDs,
then
systematically
summarizes
progress
discussing
design
principles,
functional
characteristics,
clinical
application
potential.
Finally,
it
highlights
challenges
faced
translation
BNDSs.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4898 - 4905
Published: Sept. 5, 2024
Copper
ions,
implicated
in
processes
such
as
oxidative
stress
and
inflammation,
are
believed
to
play
a
crucial
role
cardiovascular
disease,
prevalent
deadly
disease.
Despite
this,
current
diagnostic
methods
fail
detect
early
stage
disease
or
track
copper
ion
accumulation,
limiting
our
understanding
of
the
disease's
progression.
Therefore,
development
noninvasive
techniques
image
ions
is
urgently
needed
enhance
precision
therapeutic
strategies.
In
this
study,
we
report
successful
synthesis
application
ion-activated
photoacoustic
probe,
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Understanding
the
interaction
between
nanomaterials
and
cellular
structures
is
crucial
for
nanoparticle
applications
in
biomedicine.
We
have
identified
a
subtype
of
stress
granules,
called
nanomaterial-provoked
granules
(NSGs),
induced
by
gold
nanorods
(AuNRs).
These
NSGs
differ
from
traditional
SGs
their
physical
properties
biological
functions.
Uptake
AuNRs
causes
reactive
oxygen
species
accumulation
protein
misfolding
cell,
leading
to
NSG
formation.
Physically,
gel-like
core
liquid-like
shell,
influenced
positively
HSP70
negatively
HSP90
ubiquitin-proteasome
system.
promote
assembly
interacting
with
G3BP1,
reducing
energy
needed
liquid-liquid
phase
separation
(LLPS).
impact
functions
affecting
mRNA
surveillance
activating
Adenosine
5'-monophosphate
(AMP)-activated
kinase
signaling,
response.
Our
study
highlights
role
LLPS
nanomaterial
metabolism
suggests
as
potential
targets
drug
delivery
strategies,
advancing
field
nanomedicine.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Precise
imaging
of
atherosclerotic
plaques
using
biomarkers
could
prompt
the
diagnosis
and
clinical
management
atherosclerosis
(AS)-driven
cardiovascular
diseases.
MicroRNA-155
(miR-155)
plays
a
critical
role
in
AS
development,
with
its
expression
notably
upregulated
foam
cells
within
plaques.
However,
miRNA
methods
for
face
significant
challenges,
including
low
specificity,
inefficient
delivery,
poor
cell
selectivity.
Herein,
we
develop
an
endogenous
hypochlorous
acid
(HClO)-gated
cascade
signal
amplification
strategy
precise
miR-155
living
cells,
enabling
accurate
vivo
ex
detection
This
utilizes
phosphorothioate
(PT)-modified
hairpin
probe
that
is
specifically
deprotected
by
HClO
uncaged
miR-155,
triggering
catalytic
assembly
(CHA)
to
amplify
fluorescence
signals.
The
PT-CHA
probes
are
encapsulated
lipid
nanoparticles
(LNs),
followed
conjugating
phosphatidylserine
(PS)-binding
peptide
(PBP)
selectively
targeting
intensity
PT-CHA@LN-PBP
aorta
region
shows
clear
differentiation
among
AS-bearing
mice,
miR-155-/-
healthy
mice.
Moreover,
strongly
correlates
plaque
area
progression
can
discriminate
vulnerability
risk
under
curve
(AUC)
0.94.
Imaging
human
aortic
tissues
further
validates
probe's
capacity
distinguish
from
normal
endarterium.
These
findings
establish
as
noninvasive,
reliable
diagnostic
tool
assessment
AS.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
vitro
diagnostics
often
detects
biomarkers
in
body
fluids
(such
as
blood,
urine,
sputum,
and
cerebrospinal
fluids)
to
identify
life-threatening
diseases
at
an
early
stage,
monitor
overall
health,
or
provide
information
help
cure,
treat,
prevent
diseases.
Most
clinically
used
optical
diagnostic
tests
utilize
dye-labeled
biomolecules
for
biomarker
recognition
signal
readout,
which
typically
involve
complex
steps
long
processing
times.
Activatable
probes
(AOPs),
spontaneously
activate
their
signals
only
the
presence
of
disease
biomarkers,
offer
higher
signal-to-background
ratios
improved
detection
specificity.
They
also
have
potential
simplify
procedures
by
eliminating
multiple
washing
steps.
this
review,
we
summarize
recent
advances
use
AOPs
pre-clinical
clinical
fluid
across
various
diseases,
including
cancer,
nephro-urological
disorders,
infectious
digestive
We
begin
discussing
molecular
design
strategies
achieve
different
readouts
then
highlight
applications
models
fluids.
Finally,
address
challenges
future
perspectives
enhancing
advancing
precision
medicine.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
The
hypoxic
microenvironment
and
radioresistance
of
tumor
cells,
as
well
the
delay
in
efficacy
evaluation,
significantly
limit
effect
clinical
radiotherapy.
Therefore,
developing
effective
radiosensitizers
with
monitoring
response
is
great
significance
for
precise
Herein,
a
novel
radiosensitizer
(term
as:
SCuFs)
developed,
consisting
traditional
Chinese
medicine
(TCM)
compounds
salidroside,
Cu
2+
,
hydroxyl
radical
(•OH)
activated
second
near‐infrared
window
fluorescence
(NIR‐II
FL)
molecules,
which
make
radiosensitization
boosted
chemodynamic
therapy
(CDT)
efficacy.
overexpressed
glutathione
induces
SCuFs
dissociation,
allowing
deep
penetration
drug
to
whole
region.
After
X‐ray
irradiation,
salidroside
inhibits
Nuclear
factor
erythroid
2‐like
2
(Nrf2)protein
expression
blocks
cells
G2/M
phase
highest
radiosensitivity,
amplifies
reactive
oxygen
species
(ROS)
generation
exacerbate
DNA
damage,
thus
achieving
radiosensitization.
Meanwhile,
upregulated
ROS
provides
sufficient
chemical
fuel
+
‐mediated
CDT
produce
more
•OH.
NIR‐II
FL
imaging
can
monitor
•OH
changes
during
process,
confirming
process
related
This
study
not
only
achieves
cascaded
ROS‐mediated
efficacy,
but
also
useful
tool
therapeutic
showing
prospects
application.
