Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Chemoresistance
and
metastasis
are
the
main
obstacles
to
clinical
success
of
anticancer
treatment
responsible
for
most
cancer
deaths.
Developing
effective
approaches
reverse
chemoresistance
inhibit
is
essential
efficient
chemotherapy.
Mitochondria
important
sources
cellular
energy
involved
in
mediating
driving
tumor
metastasis.
Due
relatively
weak
DNA
repair
capacity
mitochondria,
targeting
mitochondria
may
provide
a
paradigm
metastatic
treatment.
Herein,
exosomes
(Exos)
modified
with
integrin
ligands
mitochondriotropic
molecules
synthesized
encapsulating
oxaliplatin
(OXA)
construct
sequentially
targeted
mitochondrion‐dysfunctional
nanodrug
(OXA@Exo‐RD).
Subsequent
investigations
confirm
that
OXA@Exo‐RD
cells
sequence,
OXA
delivered
lacking
mechanisms
reduce
likelihood
deactivation.
Furthermore,
promotes
overproduction
ROS,
inhibited
ATP
generation,
induces
mitochondria‐mediated
apoptosis
mitochondrial
dysregulation.
Finally,
shows
potential
growth
HCT116/OXA
vitro,
which
further
validated
subcutaneous
orthotopic
CRC
models,
as
well
models.
Taken
together,
this
dual‐targeting
nanomedicine
via
signaling
pathways,
providing
an
attractive
strategy
drug‐resistant
CRC.
Nano Materials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Micro/nanoscale
robots
(MNRs)
have
attracted
significant
interest
in
various
fields
because
of
their
flexible
design,
physically
controlled
maneuvering,
and
barrier
targeting.
The
execution
specific
functions
using
MNRs
relies
on
precise
propulsion
methods.
Among
the
diverse
techniques,
physical
is
widely
used
owing
to
its
noninvasive,
safe,
convenient
attributes.
This
review
provides
an
analysis
mechanisms
magnetic,
electric,
thermal,
ultrasound
presents
a
comprehensive
summary
structures,
movements,
applications
while
also
examining
advantages
shortcomings
associated
with
Finally,
challenges
perspectives
future
development
are
presented.
content
this
can
serve
as
multidisciplinary
science
reference
for
physicists,
bioengineers,
clinicians,
roboticists,
chemists
involved
pharmaceutical
design
clinical
therapy
research.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 6, 2025
In
recent
years,
medical
micro-/nanorobots
(MNRs)
have
emerged
as
a
promising
technology
for
diagnosing
and
treating
malignant
tumors.
MNRs
enable
precise,
targeted
actions
at
the
cellular
level,
addressing
several
limitations
of
conventional
cancer
diagnosis
treatment,
such
insufficient
early
diagnosis,
nonspecific
drug
delivery,
chemoresistance.
This
review
provides
an
in-depth
discussion
propulsion
mechanisms
MNRs,
including
chemical
fuels,
external
fields
(light,
ultrasound,
magnetism),
biological
propulsion,
hybrid
methods,
highlighting
their
respective
advantages
limitations.
Additionally,
we
discuss
novel
approaches
tumor
precision
surgery,
emphasizing
potential
clinical
applications.
Despite
significant
advancements,
challenges
biocompatibility,
efficiency,
translation
persist.
examines
current
state
MNR
applications
outlines
future
directions
development,
with
aim
enhancing
diagnostic
therapeutic
efficacy
facilitating
integration
into
practice.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Bladder
cancer,
a
common
malignancy
of
the
urinary
tract,
presents
complex
therapeutic
challenges,
thereby
necessitating
exploration
innovative
treatment
strategies.
This
study
introduces
novel,
self-propelled
nanomedicine
delivery
system
that
forms
nanoparticles
within
bladder
lumen
by
co-infusing
dopamine
hydrochloride,
Mn2+,
cGAMP,
and
urease
into
to
initiate
in
situ
polymerization.
The
resulting
Mn-cGAMP@PDA-urease
(DMCU)
possess
urease-modified
surface,
which
acts
as
an
engine
generate
propulsive
force
breaking
down
urea.
Consequently,
this
process
enhances
nanoparticle
retention
mucosa
facilitates
efficient
drug
delivery.
self-assembled
activate
STING
pathway,
promoting
dendritic
cell
maturation
activation
T
cells,
enhancing
anti-tumor
immune
responses.
These
remain
for
extended
period,
significantly
improving
efficacy
sustaining
release
reducing
adverse
side
effects.
In
vivo,
experiments
using
mouse
orthotopic
model
cancer
demonstrate
DMCU
tumor
suppression
compared
with
conventional
therapies.
novel
approach
integrates
nanotechnology
immunomodulation
address
chemotherapy
resistance
improve
efficacy.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Chemoresistance
and
metastasis
are
the
main
obstacles
to
clinical
success
of
anticancer
treatment
responsible
for
most
cancer
deaths.
Developing
effective
approaches
reverse
chemoresistance
inhibit
is
essential
efficient
chemotherapy.
Mitochondria
important
sources
cellular
energy
involved
in
mediating
driving
tumor
metastasis.
Due
relatively
weak
DNA
repair
capacity
mitochondria,
targeting
mitochondria
may
provide
a
paradigm
metastatic
treatment.
Herein,
exosomes
(Exos)
modified
with
integrin
ligands
mitochondriotropic
molecules
synthesized
encapsulating
oxaliplatin
(OXA)
construct
sequentially
targeted
mitochondrion‐dysfunctional
nanodrug
(OXA@Exo‐RD).
Subsequent
investigations
confirm
that
OXA@Exo‐RD
cells
sequence,
OXA
delivered
lacking
mechanisms
reduce
likelihood
deactivation.
Furthermore,
promotes
overproduction
ROS,
inhibited
ATP
generation,
induces
mitochondria‐mediated
apoptosis
mitochondrial
dysregulation.
Finally,
shows
potential
growth
HCT116/OXA
vitro,
which
further
validated
subcutaneous
orthotopic
CRC
models,
as
well
models.
Taken
together,
this
dual‐targeting
nanomedicine
via
signaling
pathways,
providing
an
attractive
strategy
drug‐resistant
CRC.
