The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria–Tetanus–Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring the Roles of Heterologous Immunity DOI Creative Commons
Theresia Santi, Juandy Jo, Alida Harahap

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1032 - 1032

Published: Sept. 9, 2024

Background: Routine childhood vaccination, e.g., for diphtheria, tetanus, and pertussis (DTP), might provide additional protection against SARS-CoV-2 infection. This concept of heterologous immunity was explored in healthy children receiving both DTP inactivated vaccines. Methods: A cross-sectional study performed on 154 aged 6–8 years old Jakarta, Indonesia. Their vaccination status the (including a diphtheria–tetanus booster vaccine at 5 old) CoronaVac (from 6 vaccines were recorded. Peripheral blood samples collected from all participants, which anti-diphtheria toxoid IgG anti-SARS-CoV-2 S-RBD antibodies T cell-derived IFN-γ measured. Results: The participants with complete had significantly higher titers than ones without (median = 0.9349 versus 0.2113 IU/mL; p < 0.0001). Upon stratification based statuses, vaccinations highest titer 1196 U/mL) concentration SARS-CoV-2-specific 560.9 mIU/mL) among groups. Conclusions: Healthy exhibited stronger cell immune responses. suggest an benefit routine generating novel pathogens, presumably via immunity.

Language: Английский

Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections DOI Creative Commons
Dana Unninayar, Emilia Liana Falcone, Hugo Chapdelaine

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Purpose Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies examined specific cell-mediated (CMI) responses to coronavirus disease 2019 (COVID-19) vaccines in this population. Therefore, the purpose study was examine HI and CMI up 6 months post-COVID-19 dose 3 adults IEIs. Methods A multi-center prospective observational conducted across Canada collect severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific data at 4- 24-week intervals after doses 2 (D2 + 4wk/D2 24wk/D3 4wk/D3 24wk). Results total 149 IEIs 423 healthy controls were recruited from July 2021 October 2023. Geometric mean anti-spike IgG (binding antibody units/mL) spike-specific T-cell [IFN-γ T cells/10 peripheral blood mononuclear cells (PBMCs)] significantly lower compared D2 4wk, D3 24wk. However, completing primary series (three for two healthy), both IEI participants persisted comparable. There strong correlation between neutralizing titer (ID50) but not ID50 CMI. only one reported case hospitalized COVID-19 before none among participants. Conclusion Adults mounted following vaccines, which than those present least 3. These support initial recommendation three-dose

Language: Английский

Citations

0
Effects of Oregano Essential Oil on IgA+, IgG+, and IgM+ Cells in the Jejunum of Castrated Holstein Bulls DOI Creative Commons
Qiyan Liu,

Wangdong Zhang,

Baoshan Wang

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(24), P. 3766 - 3766

Published: Dec. 6, 2023

The aim of this study was to investigate the effect oregano essential oil on IgA+, IgG+, and IgM+ cells in jejunum castrated Holstein bulls. Twelve bulls were randomly divided into control (YCK) (YEO) groups. Pathological changes observed by HE staining, expression levels IgA, IgG, IgM detected ELISA. distributions analysed multiplex immunofluorescence immunohistochemistry. results showed that jejunal villi detached YCK group, which may have been related inflammation, while intestinal epithelium clear intact YEO group. expressions significantly reduced 40.75%, 30.76%, 50.87%. diffusely distributed lamina propria jejunum, 17.07%, 6.44%, 6.15%, respectively. Oregano did not alter distribution characteristics or but it suppressed inflammatory response, decreased immunoglobulin content, enhanced formation an immune barrier gastrointestinal mucosa.

Language: Английский

Citations

4
Stuck in pandemic uncertainty: a review of the persistent effects of COVID-19 infection in immune-deficient people DOI Creative Commons
Bevin Manuelpillai, Mackenzie Zendt,

Emma Chang-Rabley

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: 30(8), P. 1007 - 1011

Published: March 27, 2024

Background Immune-deficient/disordered people (IDP) are underrepresented in COVID-19 studies. Specifically, there is limited research on post-SARS-CoV-2 infection outcomes, including viral persistence and long-term sequelae these populations. Objectives This review aimed to examine the published literature occurrence of persistent SARS-CoV-2 positivity, relapse, reinfections, variant coinfection, post-acute IDP. While available largely centered those with secondary immunodeficiencies, studies inborn errors immunity also included. Sources PubMed was searched using Medical Subject Headings (MeSH) terms identify relevant articles from last four years. Articles primary immunodeficiencies were chosen a special emphasis placed that studied immunity. The absence extensive cohort individuals has most this case reports, whereas focusing include larger cohort, case-control, cross-sectional solely HIV/AIDS excluded. Content Scientific suggests IDP any age more likely experience infections. adult exhibit higher rate (PASC), milder infections children may reduce their risk experiencing PASC. Reinfections coinfections occur at slightly than general population. Implications increased inter-host evolution, it unlikely enough evidence can be generated population-level support or refute hypothesis significantly result variants concern Additional relationship between could inform understanding immune response

Language: Английский

Citations

1
An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity DOI Creative Commons

Emma Chang-Rabley,

Menno C. van Zelm, Emily Ricotta

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(6), P. 675 - 675

Published: June 18, 2024

The SARS-CoV-2 pandemic has heightened concerns about immunological protection, especially for individuals with inborn errors of immunity (IEI). While COVID-19 vaccines elicit strong immune responses in healthy individuals, their effectiveness IEI patients remains unclear, particularly against new viral variants and vaccine formulations. This uncertainty led to anxiety, prolonged self-isolation, repeated vaccinations uncertain benefits among patients. Despite some level response from vaccination, the definition protective is still unknown. Given susceptibility severe COVID-19, strategies such as immunoglobulin replacement therapy (IgRT) monoclonal antibodies have been employed provide passive immunity, protection both current emerging variants. review examines efficacy antibody-based therapies patients, capacity recognize variants, necessary advances required ongoing people IEIs.

Language: Английский

Citations

1
Impact of Exposure to Vaccination and Infection on Cellular and Antibody Response to SARS-CoV-2 in CVID Patients Through COVID-19 Pandemic DOI
Giulia Costanzo, Carla Maria Deiana, Giuseppina Sanna

et al.

Journal of Clinical Immunology, Journal Year: 2023, Volume and Issue: 44(1)

Published: Dec. 22, 2023

Language: Английский

Citations

1
An Overview of the Immune Response to COVID-19 Vaccination and Strategies to Boost SARS-CoV-2 Immunity in People with Inborn Errors of Immunity DOI Open Access

Emma Chang-Rabley,

Menno C. van Zelm, Emily Ricotta

et al.

Published: May 10, 2024

The ongoing SARS-CoV-2 pandemic has raised concerns surrounding immunological protection against the virus, particularly for people with inborn errors of immunity (IEI). While COVID-19 vaccination induces robust antibody, memory B-cell, and T-cell responses in healthy individuals, how well protects IEI infection severe disease remains unclear – especially context new viral variants vaccine formulations leading to anxiety, self-isolation, repeated limited evidence increased efficacy. Whilst most generate some level cellular and/or humoral vaccination, durability response are unclear. Alongside antibody-based therapeutics aimed at limiting this cohort. Immunoglobulin replacement therapy (IgRT) provides passive antibody-deficient individuals. However, successfully prevent infection, a sufficient number neutralizing antibodies must be present product. circulating eventually IgRT products (both from natural donors), their capacity recognize is limited. Furthermore, while pre- post-exposure prophylaxis can effective, they susceptible decreased efficacy variant evolution. This review an in-depth overview current knowledge about IEIs, SARS-CoV-2-specific antibody products, technological advances required continued IEI.

Language: Английский

Citations

0
The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria–Tetanus–Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring the Roles of Heterologous Immunity DOI Creative Commons
Theresia Santi, Juandy Jo, Alida Harahap

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1032 - 1032

Published: Sept. 9, 2024

Background: Routine childhood vaccination, e.g., for diphtheria, tetanus, and pertussis (DTP), might provide additional protection against SARS-CoV-2 infection. This concept of heterologous immunity was explored in healthy children receiving both DTP inactivated vaccines. Methods: A cross-sectional study performed on 154 aged 6–8 years old Jakarta, Indonesia. Their vaccination status the (including a diphtheria–tetanus booster vaccine at 5 old) CoronaVac (from 6 vaccines were recorded. Peripheral blood samples collected from all participants, which anti-diphtheria toxoid IgG anti-SARS-CoV-2 S-RBD antibodies T cell-derived IFN-γ measured. Results: The participants with complete had significantly higher titers than ones without (median = 0.9349 versus 0.2113 IU/mL; p < 0.0001). Upon stratification based statuses, vaccinations highest titer 1196 U/mL) concentration SARS-CoV-2-specific 560.9 mIU/mL) among groups. Conclusions: Healthy exhibited stronger cell immune responses. suggest an benefit routine generating novel pathogens, presumably via immunity.

Language: Английский

Citations

0