Microbial education plays a crucial role in harnessing the beneficial properties of microbiota for infectious disease protection in Crassostrea gigas DOI Creative Commons
Luc Dantan,

Prunelle Carcassonne,

Lionel Dégremont

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Abstract The increase in marine diseases, particularly economically important mollusks, is a growing concern. Among them, the Pacific oyster ( Crassostrea gigas ) production faces challenges from several such as Oyster Mortality Syndrome (POMS) or vibriosis. microbial education, which consists of exposing host immune system to beneficial microorganisms during early life stages promising approach against diseases. This study explores concept education using controlled and pathogen-free bacterial communities assesses its protective effects POMS Vibrio aestuarianus infections, highlighting potential applications production. We demonstrate that it possible educate by adding larval stage. Adding culture based mixes larvae protects only disease while whole donors both efficiency protection depends on origin composition used for exposure. No preferential was observed when oysters were stimulated with their sympatric strains. Furthermore, added bacteria not maintained into microbiota, but this addition induced long term changes microbiota gene expression. Our reveals successful introducing improved long-term resistance critical diseases (POMS infections) aquaculture.

Language: Английский

Microbial education plays a crucial role in harnessing the beneficial properties of microbiota for infectious disease protection in Crassostrea gigas DOI Creative Commons
Luc Dantan,

Prunelle Carcassonne,

Lionel Dégremont

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Abstract Background Recently, the frequency and severity of marine diseases have increased in association with global changes, molluscs economic interest are particularly concerned. Among them, Pacific oyster ( Crassostrea gigas ) production faces challenges from several such as Oyster Mortality Syndrome (POMS) or vibriosis. Various strategies genetic selection immune priming been developed to fight some these infectious diseases. The microbial education, which consist exposing host system beneficial microorganisms during early life stages is a promising approach against This study explores concept education using controlled pathogen-free bacterial communities assesses its protective effects POMS Vibrio aestuarianus infections, highlighting potential applications production. Results We demonstrate that it possible educate by adding larval stage. Adding culture based mixes larvae protects only disease while whole donors both efficiency protection depends on origin composition used for exposure. No preferential was observed when oysters were stimulated their sympatric strains. further show added bacteria not maintained microbiota after exposure, but this addition induced long term changes gene expression. Conclusion Our reveals successful introducing micro-organisms improved long-term resistance critical (POMS infections) aquaculture.

Language: Английский

Citations

0
Reproductive aging weakens offspring survival and constrains the telomerase response to herpesvirus in Pacific oysters DOI Creative Commons
Andréaz Dupoué,

Hugo Koechlin,

Matthias Huber

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(37)

Published: Sept. 11, 2024

Telomere length (TL) is increasingly recognized as a molecular marker that reflects how reproductive aging affects intergenerational transmissions. Here, we investigated the effects of parental age on offspring survival and regulation TL by examining telomere-elongating activity telomerase in Pacific oyster. We assessed classical hallmarks parents at three classes (young, middle-aged, old) crossbred them using split-brood design to examine consequences nine maternal-by-paternal combinations their offspring. Reproductive leads increased larval mortality accelerated telomere shortening spats, rendering more susceptible infection Ostreid herpesvirus. Viral exposure stimulates activity, response identified adaptive, but weakened aging. While lengthens spat’s telomere, paradoxically, longer individual predicts higher adults. The telomerase-telomere complex appeared conservative biomarker for distinguishing survivors losers upon polymicrobial diseases.

Language: Английский

Citations

0
Microbial education plays a crucial role in harnessing the beneficial properties of microbiota for infectious disease protection in Crassostrea gigas DOI Creative Commons
Luc Dantan,

Prunelle Carcassonne,

Lionel Dégremont

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Abstract The increase in marine diseases, particularly economically important mollusks, is a growing concern. Among them, the Pacific oyster ( Crassostrea gigas ) production faces challenges from several such as Oyster Mortality Syndrome (POMS) or vibriosis. microbial education, which consists of exposing host immune system to beneficial microorganisms during early life stages promising approach against diseases. This study explores concept education using controlled and pathogen-free bacterial communities assesses its protective effects POMS Vibrio aestuarianus infections, highlighting potential applications production. We demonstrate that it possible educate by adding larval stage. Adding culture based mixes larvae protects only disease while whole donors both efficiency protection depends on origin composition used for exposure. No preferential was observed when oysters were stimulated with their sympatric strains. Furthermore, added bacteria not maintained into microbiota, but this addition induced long term changes microbiota gene expression. Our reveals successful introducing improved long-term resistance critical diseases (POMS infections) aquaculture.

Language: Английский

Citations

0