Cited by Data-driven synapse classification reveals a logic of glutamate receptor composition

BDNF mediates the heart-brain axis: implications for cardiovascular diseases and mental disorders DOI

Huang Fan, Jiahao Duan, Wei Liu

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

β-adrenergic receptor activation modulates the induction of complex spike burst-dependent LTP by regulating multiple forms of heterosynaptic plasticity DOI

Thomas J. O’Dell

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

ABSTRACT The modulatory neurotransmitter norepinephrine and activation of β-adrenergic receptors (β-ARs) has a crucial role in hippocampus-dependent forms learning. Although β-AR also facilitates the induction Hebbian LTP at excitatory synapses hippocampus, recent findings indicate that non-Hebbian form synaptic plasticity, known as behavioral timescale plasticity (BTSP), underlies spatial Because little is about noradrenergic signaling BTSP, I examined effects on BTSP-like, complex spike (CS) burst-dependent induced by theta-pulse stimulation (TPS) protocols CA1 region mouse hippocampal slices. find not only enhances homosynaptic potentiation transmission TPS but regulates how interact during CS LTP. ability to cooperative fashion undergo LTP, which mediated heterosynaptic facilitation EPSP-evoked bursting brief trains TPS, was enhanced activation. Moreover, unlike conventional where requires near synchronous coactivation synapses, enabled interactions between activated up ten seconds apart. potent competition emerges longer TPS. This effect depression produces an unusual, bidirectional modulation β-AR-mediated suppression other synapses. Together, these fundamental properties postsynaptic rules modulating multiple plasticity.

Language: Английский

Citations

Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus DOI

Zhenrui Liao, Attila Losonczy

Annual Review of Neuroscience, Journal Year: 2024, Volume and Issue: 47(1), P. 187 - 209

Published: April 25, 2024

The hippocampus is critical for memory and spatial navigation. ability to map novel environments, as well more abstract conceptual relationships, fundamental the cognitive flexibility that humans other animals require survive in a dynamic world. In this review, we survey recent advances our understanding of how implemented anatomically functionally by hippocampal circuitry, during both active exploration (online) rest (offline). We discuss advantages limitations spike timing–dependent plasticity recently discovered behavioral timescale synaptic supporting distinct learning modes hippocampus. Finally, suggest complementary roles these types explaining many-shot single-shot rules could work together support maps.

Language: Английский

Citations

Nonlinear slow-timescale mechanisms in synaptic plasticity DOI

Cian O’Donnell

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 82, P. 102778 - 102778

Published: Aug. 30, 2023

Language: Английский

Citations

Variable recruitment of distal tuft dendrites shapes new hippocampal place fields DOI

Justin K. O’Hare, Jamie Wang, Margjele D. Shala

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

SUMMARY Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are widely thought to initiate place field formation locally generating prolonged, globally-spreading Ca 2+ spikes known as plateau potentials. However, the hitherto experimental inaccessibility of distal in hippocampus has rendered their vivo function entirely unknown. Here we gained direct optical access this elusive dendritic compartment. We report that do not serve point origin for field-forming Instead, timing and extent peri-formation recruitment is variable closely predicts multiple properties resultant fields. Therefore, play a more powerful role hippocampal feature selectivity than simply initiating formation. Moreover, accompanied global influx previously thought. In addition shaping somatic fields, possess own local Tuft fields back-shifted relative soma appear maintain via post-formation Through observation, provide revised basis during navigational learning.

Language: Английский

Citations

CaMKII activity and metabolic imbalance-related neurological diseases: Focus on vascular dysfunction, synaptic plasticity, amyloid beta accumulation, and lipid metabolism DOI

Jeongsik Yong, Juhyun Song

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116688 - 116688

Published: April 30, 2024

Metabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive fat accumulation and dyslipidemia, known to be accompanied neuropathological symptoms such as memory loss, anxiety, depression. As the number of MetS patients rapidly increasing globally, studies on mechanisms metabolic imbalance-related neuropathology are emerging an important issue. Ca2+/calmodulin-dependent kinase II (CaMKII) main Ca2+ sensor contributes diverse intracellular signaling in peripheral organs central nervous system (CNS). CaMKII exerts functions cells, related RNA splicing, reactive oxygen species (ROS) generation, cytoskeleton, protein-protein interactions. In CNS, regulates vascular function, neuronal circuits, neurotransmission, synaptic plasticity, amyloid beta toxicity, lipid metabolism, mitochondrial function. Here, we review recent evidence for role neuropathologic issues associated with disorders.

Language: Английский

Citations

Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion DOI

Mark Plitt, Konstantin Kaganovsky, Thomas C. Südhof

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 21, 2023

Summary Rapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component synaptic plasticity. However, it unknown how this process supports specific neural computations during behavior. To bridge gap, we combined conditional genetic deletion machinery, Syntaxin3 (Stx3), in hippocampal CA1 neurons mice with population vivo calcium imaging. This approach revealed that Stx3 necessary for forming dynamics support novelty processing, spatial reward memory and offline consolidation. In contrast, was dispensable maintaining aspects code exist presynaptic such as representations context space. Thus, manipulating identified specifically require restructuring trafficking distinguished them from representation could be inherited upstream brain regions or learned through other mechanisms.

Language: Английский

Citations

Neuronal calcium spikes enable vector inversion in theDrosophilabrain DOI

Itzel G. Ishida, Sachin Sethi, Thomas L. Mohren

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 24, 2023

A typical neuron signals to downstream cells when it is depolarized and firing sodium spikes. Some neurons, however, also fire calcium spikes hyperpolarized. The function of such bidirectional signaling remains unclear in most circuits. Here we show how a class that participates vector computation the fly central complex employs hyperpolarization-elicited invert two-dimensional mathematical vectors. When switch from spikes, this leads ~180° realignment between encoded neuronal population fly's internal heading signal, thus inverting vector. We rely on T-type channel Ca-α1T, argue, via analytical experimental approaches, these enable computations portions angular space would otherwise be inaccessible. These results reveal seamless interaction molecular, cellular circuit properties for implementing math brain.

Language: Английский

Citations

Non-spatial hippocampal behavioral timescale synaptic plasticity during working memory is gated by entorhinal inputs DOI

Conor C. Dorian, Jiannis Taxidis, Peyman Golshani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

ABSTRACT Behavioral timescale synaptic plasticity (BTSP) is a form of potentiation where the occurrence single large plateau potential in CA1 hippocampal neurons leads to formation reliable place fields during spatial learning tasks. We asked whether BTSP could also be mechanism for generation non-spatial responses hippocampus and what roles medial lateral entorhinal cortex (MEC LEC) play driving BTSP. By performing simultaneous calcium imaging dorsal chemogenetic inhibition LEC or MEC while mice performed an olfactory working memory task, we discovered BTSP-like events which formed stable odor-specific fields. Critically, success rate generating significant odor-field increased with event amplitude, exhibited asymmetrical newly odor-fields preceding timepoint their induction event. found that distinct modulating BTSP: reduced frequency events, generation. Using two-photon temporammonic axons projecting CA1, projections were strongly odor selective even early task learning, projection odor-selectivity but remained weaker than LEC. Finally, both slowed representational drift representations across 48 hours. Altogether, information from strong odor-timed activity are crucial may role explaining one-shot information.

Language: Английский

Citations

CaMKII mechanisms in plasticity, learning and memory: Approaches and concepts DOI

K. Ulrich Bayer, Carolyn N. Brown, Karl-Peter Giese

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations