The Gut-Brain Axis in Neurodevelopmental Disorders: Mechanistic Insights, Clinical Implications, and Public Health Strategies DOI
Nicholas A Kerna, Dabeluchi C. Ngwu,

Chukwuemeka O. Keke

et al.

European Journal of Theoretical and Applied Sciences, Journal Year: 2024, Volume and Issue: 2(6), P. 580 - 596

Published: Nov. 1, 2024

The integration of gut microbiota research into the understanding and treatment neurodevelopmental disorders has profound implications for both clinical practice public health. microbial community’s influence on neural development through mechanisms such as metabolites, immune regulation, gene expression underscores complexity like autism spectrum disorder (ASD) attention-deficit hyperactivity (ADHD). As continues to unravel intricate relationship between brain function, innovative therapeutic interventions, including probiotics, prebiotics, fecal transplantation, hold potential improve symptoms outcomes. However, safety long-term effectiveness these therapies remain critical areas future investigation. Advances in diagnostic tools personalized medicine, which incorporate biomarkers, offer exciting prospects early detection tailored treatments, ultimately improving quality life individuals with disorders. Continued interdisciplinary collaboration is essential translating findings practical solutions that address underlying complex This review highlights role disorders, emphasizing importance genetic interactions shaping development.

Language: Английский

Synergy of Traditional Practices and Modern Technology: Advancing the Understanding and Applications of Microbial Resources and Processes in Fermented Foods DOI
Yuli Zhang,

X.M. Zhu,

Nan Wang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104891 - 104891

Published: Jan. 1, 2025

Language: Английский

Citations

1
Mathematical Modeling and Artificial Intelligence to Explore Connections Between Glaucoma and the Gut Microbiome DOI Creative Commons
Madeline C. Rocks, P. K. Bhatnagar,

Alice Verticchio Vercellin

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 343 - 343

Published: Feb. 14, 2025

Background and Objectives: Glaucoma is a major cause of irreversible blindness, with primary open-angle glaucoma (POAG) being the most prevalent form. While elevated intraocular pressure (IOP) well-known risk factor for POAG, emerging evidence suggests that human gut microbiome may also play role in disease. This review synthesizes current findings on relationship between glaucoma, focus mathematical modeling artificial intelligence (AI) approaches to uncover key insights. Materials Methods: A comprehensive literature search was conducted using PubMed Google Scholar, covering studies from its inception 1 August 2024. Selected included basic science, observational research, those incorporating mathematical-related models. Results: Traditional statistical machine learning approaches, such as random forest regression Mendelian randomization, have identified associations specific microbiota POAG features. These highlight potential AI explore complex, nonlinear interactions gut-eye axis. However, limitations include variability study designs lack integrative, mechanistic Conclusions: Preliminary supports existence axis influencing Combining data-driven mechanism-driven models could identify therapeutic targets novel biomarkers. Future research should prioritize longitudinal diverse populations integrate physiological data improve model accuracy clinical relevance. Furthermore, physics-based deepen our understanding advancing beyond associative actionable

Language: Английский

Citations

0
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy DOI Creative Commons
Vicky Yao,

Nairui Fan,

Shuxia Ma

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 18, 2025

ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized

Language: Английский

Citations

0
The role of secondary genomes in neurodevelopment and co-evolutionary dynamics DOI

Siddharth Singh,

Vaishali Saini, Hem Chandra Jha

et al.

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Gut-Brain Axis in Neurodevelopmental Disorders: Mechanistic Insights, Clinical Implications, and Public Health Strategies DOI
Nicholas A Kerna, Dabeluchi C. Ngwu,

Chukwuemeka O. Keke

et al.

European Journal of Theoretical and Applied Sciences, Journal Year: 2024, Volume and Issue: 2(6), P. 580 - 596

Published: Nov. 1, 2024

The integration of gut microbiota research into the understanding and treatment neurodevelopmental disorders has profound implications for both clinical practice public health. microbial community’s influence on neural development through mechanisms such as metabolites, immune regulation, gene expression underscores complexity like autism spectrum disorder (ASD) attention-deficit hyperactivity (ADHD). As continues to unravel intricate relationship between brain function, innovative therapeutic interventions, including probiotics, prebiotics, fecal transplantation, hold potential improve symptoms outcomes. However, safety long-term effectiveness these therapies remain critical areas future investigation. Advances in diagnostic tools personalized medicine, which incorporate biomarkers, offer exciting prospects early detection tailored treatments, ultimately improving quality life individuals with disorders. Continued interdisciplinary collaboration is essential translating findings practical solutions that address underlying complex This review highlights role disorders, emphasizing importance genetic interactions shaping development.

Language: Английский

Citations

1