The recent development, application, and future prospects of muscle atrophy animal models DOI Creative Commons
Gongchang Zhang,

Fengjuan Hu,

Tingting Huang

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский

Selenium and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications DOI Creative Commons

Shahidin,

Yan Wang, Yi-Long Wu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 437 - 437

Published: Jan. 21, 2025

Selenium (Se) is an essential trace element crucial for human health that primarily functions as immunonutrient. It incorporated into polypeptides such selenocysteine (SeC) and selenomethionine (SeMet), two key amino acids involved in various biochemical processes. All living organisms can convert inorganic Se biologically active organic forms, with SeMet being the predominant form a precursor SeC production humans animals. The genome encodes 25 selenoprotein genes, which incorporate low-molecular-weight compounds of SeC. Organic Se, especially selenoproteins, more efficiently absorbed than driving demand selenoprotein-based products, functional foods. Se-enriched foods offer practical means delivering bioavailable are associated enhanced antioxidant properties benefits. Recent advancements synthesis have improved our understanding their roles defense, cancer prevention, immune regulation, anti-inflammation, hypoglycemia, cardiovascular health, Alzheimer’s disease, fertility, COVID-19. This review highlights selenoproteins biological functions, biosynthetic pathways, emerging applications while highlighting need further research.

Language: Английский

Citations

1
A novel zearalenone lactonase can effectively mitigate zearalenone-induced reproductive toxicity in gilts DOI

Jiali Song,

Zhe Peng,

Y Y Ning

et al.

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108257 - 108257

Published: Jan. 1, 2025

Language: Английский

Citations

0
T-2 toxin-induced splenic injury by disrupting the gut microbiota–spleen axis via promoting IL-6/JAK/STAT1 signaling-mediated inflammation and apoptosis and its mitigation by elemental nano-selenium DOI
Meng Liu, Xuewu Li, Hua Sun

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Five glutathione S-transferase isozymes played crucial role in the detoxification of aflatoxin B1 in chicken liver DOI Creative Commons
Jiang Deng, Zhe Peng, Zhiyuan Xia

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 7, 2025

Abstract Background AFB 1 -8,9-exo-epoxide (AFBO) is the highly toxic product of Aflatoxin B (AFB ). Glutathione S -transferases (GSTs) play pivotal roles in detoxifying by catalyzing conjugation AFBO with glutathione (GSH). Although there are over 20 GST isozymes that have been identified chicken, involved detoxification process not yet. The objective this study was to determine which played key role . Results A total 17 pcDNA3.1(+)-GST isozyme plasmids were constructed and genes overexpressed 80–2,500,000 folds chicken Leghorn male hepatoma (LMH) cells. Compared treatment, overexpression GSTA2X, GSTA3, GSTT1L, GSTZ1-1, GSTZ1-2 increased cell viability 6.5%–17.0% LMH Moreover, five reduced release lactate dehydrogenase reactive oxygen species 8.8%–64.4%, 57.2%–77.6%, respectively, as well enhanced production AFBO-GSH 15.8%–19.6%, thus mitigating DNA damage induced After comprehensive evaluation various indicators, GSTA2X displayed best effects against expressed Pichia pastoris X-33 its enzymatic properties for GSH showed optimum temperature pH 20–25 °C 7.6–8.6 kinetic parameter V max 0.23 nmol/min/mg Michaelis constant 86.05 μmol/L substrate. Conclusions In conclusion, detoxification, will provide new remediation strategies prevent aflatoxicosis chickens.

Language: Английский

Citations

0
Selenium Reduces the Accumulation of as in Rice Grains by Weakening the Mobility of as in Rice Rhizosphere and Root System DOI

Yongqiang Yang,

Yanfang Wu, Xin Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
The recent development, application, and future prospects of muscle atrophy animal models DOI Creative Commons
Gongchang Zhang,

Fengjuan Hu,

Tingting Huang

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский

Citations

0