Cited by Bioactive Self‐Assembled Nanoregulator Enhances Hematoma Resolution and Inhibits Neuroinflammation in the Treatment of Intracerebral Hemorrhage

Intricate Role of the Cyclic Guanosine Monophosphate Adenosine Monophosphate Synthase-Stimulator of Interferon Genes (cGAS-STING) Pathway in Traumatic Brain Injury-Generated Neuroinflammation and Neuronal Death DOI

Deepali Kumari,

Simranjit Kaur,

Manoj P. Dandekar

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(10), P. 2936 - 2950

Published: Oct. 2, 2024

The secondary insult in the aftermath of traumatic brain injury (TBI) causes detrimental and self-perpetuating alteration cells, resulting aberrant function death neuronal cells. is mainly driven by activation neuroinflammatory pathway. Among several classical pathways, cGAS-STING pathway, a primary route, encompasses cyclic GMP-AMP synthase (cGAS), stimulator interferon genes (STING), downstream signaling adaptor. Recently, research domain has gained exponential attention. stimulation machinery corresponding neuroinflammation have also been reported after TBI. In addition to critical contribution neuroinflammation, provokes cell through various mechanisms. This review highlights structural molecular mechanisms associated with We focus on intricate relationship framework between (autophagy, apoptosis, pyroptosis, ferroptosis, necroptosis) suggest that targeting may open new therapeutic strategies combat neurodegeneration

Language: Английский

Citations

Engineered Bio‐Heterojunction with Robust ROS‐Scavenging and Anti‐Inflammation for Targeted Acute Pancreatitis Therapy DOI

Hongxing Shi,

Yaoyu Guo,

Chong Geng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 35(3)

Published: Oct. 12, 2024

Abstract Acute pancreatitis (AP) is one of the most severe mortal inflammatory diseases worldwide, which characterized by over‐activation reactive oxygen species (ROS)‐induced inflammation and pancreatic enzymes (PEs). As PEs induced ROS exacerbate progression AP, therefore, scavenging within a prerequisite for AP treatment. To address daunting issue, engineered bio‐heterojunctions (bio‐HJs) consisting Mo 2 C‐Au (MA), phospholipid, protease inhibitors are devised. First, decorated phospholipid facilitate delivery MA to pancreas as well neutralization PEs. Next, exhibits outstanding antioxidant abilities, primarily benefiting from increased empty orbitals on attributed electron transfer between C Au confirmed theoretical calculation. The in vitro experiments demonstrate that bio‐HJs exhibit splendid biocompatibility, excellent trypsin neutralization, efficient elimination properties. More encouragingly, vivo studies further reveal prevent infiltration cells alleviate severity suppressing ROS‐induced activation TLR4‐ERK1/2 MAPK‐MLCK signaling pathway. envisioned, represent promising approach treatment prevention AP.

Language: Английский

Citations

Bacteria‐Mediated Tumor‐Targeting Delivery of Multienzyme‐Mimicking Covalent Organic Frameworks Promoting Pyroptosis for Combinatorial Sono‐Catalytic Immunotherapy DOI

Yunyun Liu,

Lihua Xiang,

Yitong Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Pyroptosis, an inflammatory cell death, has attracted great attention for potentiating a strong immune response against tumor cells. However, developing powerful pyroptosis inducers and then activating specific still remains challenging. Herein, PEG‐CuP‐COF@∆St nanosystem is rationally designed, consisting of PEG‐CuP‐COF nanozyme tumor‐targeting bacteria the Salmonella Typhimurium strain VNP20009 (ΔSt), with affinity hypoxic microenvironment. The nanozymes possessed excellent sonodynamic performance multienzyme‐mimicking activities to generate reactive oxygen species (ROS) induce potent pyroptosis. superoxide dismutase‐ peroxidase‐mimicking catalytically produced hydrogen peroxide (H 2 O ) hydroxyl radicals (•OH) which have important value in triggering acute responses Moreover, showed outstanding glutathione activities, impairing antioxidant defense cells enhancing efficiency by making them more vulnerable ROS‐induced damage. During vivo studies, its self‐driven property exhibited impressive capability activated Caspase‐3/gasdermin E‐dependent inhibit growth. More importantly, it induced memory effect prevent bone metastasis. In summary, this study introduces innovative approach combinatorial sono‐catalytic immunotherapy using bacteria‐mediated delivery as inducers.

Language: Английский

Citations

Nucleophosmin 1 overexpression enhances neuroprotection by attenuating cellular stress in traumatic brain injury DOI

Jiashuo Zhao,

Weixin Xing,

Chengyuan Ji

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 383, P. 115019 - 115019

Published: Oct. 18, 2024

Language: Английский

Citations

Bioactive Self‐Assembled Nanoregulator Enhances Hematoma Resolution and Inhibits Neuroinflammation in the Treatment of Intracerebral Hemorrhage DOI

Wenyan Yu,

Chengyuan Che,

Yi Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Hematoma and secondary neuroinflammation continue to pose a significant challenge in the clinical treatment of intracerebral hemorrhage (ICH). This study describes nanoregulator formed through self-assembly Mg

Language: Английский

Citations