Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Nasopharyngeal
cancer
(NPC)
is
a
challenging
malignancy
with
poor
prognosis
due
to
late
diagnosis
and
resistance
conventional
treatments.
Nanotechnology
offers
promising
solutions
address
these
limitations
by
enabling
targeted
drug
delivery,
enhancing
therapeutic
efficacy,
facilitating
multimodal
treatment
strategies.
By
leveraging
the
unique
properties
of
nanomaterials
nanocarrier
systems,
innovative
approaches
for
early
detection,
treatment,
therapy
can
be
developed,
paving
way
more
effective
personalized
management
NPC.
This
review
provides
comprehensive
overview
recent
developments
applications
nanotechnology
in
NPC
therapy,
focusing
on
improving
stability,
biodistribution,
delivery
tumors.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(2)
Published: Dec. 4, 2024
Abstract
Cancer
treatment
has
witnessed
revolutionary
advancements
marked
by
the
emergence
of
immunotherapy,
specifically
immune
checkpoint
blockade
(ICB).
However,
inherent
low
immunogenicity
tumor
cells
and
intricate
immunosuppressive
network
within
microenvironment
(TME)
pose
significant
challenges
to
further
development
immunotherapy.
Nanotechnology
ushered
in
unprecedented
opportunities
vast
prospects
for
Nevertheless,
traditional
nano‐formulations
often
rely
on
inducing
apoptosis
kill
cancer
cells,
which
encounters
issue
silencing,
hindering
effective
activation.
The
non‐apoptotic
modes
regulated
cell
death
(RCD),
including
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
cuproptosis,
have
gradually
garnered
attention.
These
pathways
can
induce
immunogenic
(ICD),
enhancing
This
review
comprehensively
explores
advanced
nano‐formulation
design
strategies
their
applications
immunotherapy
promoting
RCD
recent
years.
It
also
discusses
potential
advantages
these
tumor‐specific
RCD.
By
deeply
understanding
significance
synergistic
this
article
provides
valuable
insights
developing
more
nano‐delivery
systems
that
robustly
highly
modes,
offering
novel
research
avenues
address
clinical
encountered
represented
ICB.
Cancer Pathogenesis and Therapy,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Copper
(Cu)
is
an
indispensable
micronutrient
that
maintains
signaling
pathways
and
biological
homeostasis
in
almost
all
cell
types;
however,
its
excess
affects
the
tricarboxylic
acid
cycle,
causes
accumulation
of
fatty
acylated
proteins,
destabilization
iron–sulfur
cluster
increases
levels
intracellular
reactive
oxygen
species,
leading
to
proteotoxic
stress
death.
Cuproptosis,
a
form
Cu-dependent
death,
differs
from
other
types
regulated
death
(RCD)
was
first
reported
Science
2022.
Recently,
RCD
have
been
targeted
cancer
therapy.
However,
escape
apoptosis
tumor
cells
resistance
treatment
recurrence.
Therefore,
there
urgent
need
study
alternative
mechanisms
mortality.
Compared
normal
patients,
significant
increase
serum
Cu
ion
has
observed
patients
with
tumors.
Moreover,
proliferation,
angiogenesis,
metastasis
are
associated
cuproptosis.
Thus,
exploring
related
cuproptosis
will
provide
new
perspective
for
development
anti-cancer
drugs.
Importantly,
closely
modulation
anti-tumor
immunity.
The
expression
cuproptosis-related
genes
(CRGs)
significantly
correlated
immune
infiltration
checkpoint
programmed
protein
1
(PD-1)/programmed
death-ligand
(PD-L1).
Based
on
these
findings,
series
drugs
used
tumor-targeted
combination
therapy
or
as
synergists.
elucidating
role
per
stage
microenvironment
(TIME)
helpful
clarifying
potential
value
specific
cancers.
In
this
review,
we
summarize
based
regulation
concentration.
two
approaches
may
help
researchers
develop
more
therapies
targeting
pathways.
focused
effect
TIME
systematically
discussed
CRGs
immunity
considering
CRG-related
pathways,
prognosis
scoring
system,
immunotherapy,
experiments
bioinformatics
prediction
models,
ideas
anticancer
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 16, 2024
Abstract
Immune
checkpoint
blockade
(ICB)
generates
sustained
responses
in
immunogenic
cancers,
but
its
effectiveness
is
limited
tumors
lacking
immune
activity.
Here,
we
construct
a
bioinspired
bimetallic
ions
functionalized
nanoscale
metal-organic
framework
(NMOF)
single-atom
nanozyme
(SAzyme)
loaded
with
doxorubicin
(Dox)
(NMOF-Fe/Cu-Dox
nanocomposite)
to
effectively
trigger
anti-tumor
while
addressing
the
immunosuppressive
tumor
microenvironment
(TME).
The
NMOF-Fe/Cu-Dox
nanocomposite
has
been
demonstrated
efficiently
reverse
TME
by
generating
reactive
oxygen
species
and
oxidizing
glutathione.
Camouflaging
nanocomposites
cancer
cell
membrane
(NMOF-Fe/Cu-Dox@M)
enables
navigation
region
through
homologous
targeting.
highly
efficient
uptaken
cells
selectively
induced
synergistic
ferroptosis
cuproptosis
these
cells.
Furthermore,
vitro
vivo
experiments
demonstrate
that
can
polarize
tumor-associated
macrophages
(TAMs)
towards
anti-tumoral
M1
phenotype
significantly
diminish
pro-tumoral
M2
phenotype.
We
find
NMOF-Fe/Cu-Dox@M
could
induce
of
macrophages,
no
effect
macrophages.
In
addition,
significant
increase
infiltrating
CD8
+
T
cells,
remarkable
decrease
CD4
regulatory
were
observed.
These
findings
suggested
modulate
TME,
enhance
tumoricidal
immunity
elevate
therapeutic
efficiency
ICB.
Moreover,
combination
αPD-1
eradicated
hepatocellular
carcinoma
,
outperforming
use
either
or
alone.
summary,
our
study
presents
strategy
leverages
coordinated
ICB,
underscoring
promise
combined
chemoimmunotherapy.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 8, 2024
Osteosarcoma,
a
highly
aggressive
malignant
bone
tumor,
is
significantly
influenced
by
the
intricate
interactions
within
its
tumor
microenvironment
(TME),
particularly
involving
neutrophils.
This
review
delineates
multifaceted
roles
of
neutrophils,
including
tumor-associated
neutrophils
(TANs)
and
neutrophil
extracellular
traps
(NETs),
in
osteosarcoma’s
pathogenesis.
TANs
exhibit
both
pro-
anti-tumor
phenotypes,
modulating
growth
immune
evasion,
while
NETs
facilitate
cell
adhesion,
migration,
immunosuppression.
Clinically,
neutrophil-related
markers
such
as
neutrophil-to-lymphocyte
ratio
(NLR)
predict
patient
outcomes,
highlighting
potential
for
neutrophil-targeted
therapies.
Unraveling
these
complex
crucial
developing
novel
treatment
strategies
that
harness
TME
to
improve
osteosarcoma
management.
Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Nasopharyngeal
cancer
(NPC)
is
a
challenging
malignancy
with
poor
prognosis
due
to
late
diagnosis
and
resistance
conventional
treatments.
Nanotechnology
offers
promising
solutions
address
these
limitations
by
enabling
targeted
drug
delivery,
enhancing
therapeutic
efficacy,
facilitating
multimodal
treatment
strategies.
By
leveraging
the
unique
properties
of
nanomaterials
nanocarrier
systems,
innovative
approaches
for
early
detection,
treatment,
therapy
can
be
developed,
paving
way
more
effective
personalized
management
NPC.
This
review
provides
comprehensive
overview
recent
developments
applications
nanotechnology
in
NPC
therapy,
focusing
on
improving
stability,
biodistribution,
delivery
tumors.
