Lubricating and Dual‐Responsive Injectable Hydrogels Formulated From ZIF‐8 Facilitate Osteoarthritis Treatment by Remodeling the Microenvironment DOI
Hongtao Zhang, Shiguo Yuan, Boyuan Zheng

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and proliferation bone, along with ongoing inflammation. Although precise pathogenesis remains somewhat elusive, restoring homeostatic balance intra‐articular microenvironment crucial for management OA. Intra‐articular injection medication one most direct effective treatment methods; however, injectable drugs used osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, frequent injections, leading increased risk infection suboptimal therapeutic outcomes. In this study, lubricating dual‐responsive hydrogel based on zeolitic imidazolate frameworks‐8 (ZIF‐8) impregnated Quercetin (Que) designed, which can facilitate OA remodeling microenvironment. The prepared nanocomposite (MH/CCM@ZIF‐8@Que) exhibits pH reactive oxygen species (ROS) responsiveness, alongside controllable release bioactive substances modulate bone tissue, thereby mitigating synovitis degeneration matrix, while simultaneously facilitating repair. This developed thermosensitive hydrogel, effectively balances lubrication controlled substances, represents highly promising approach osteoarthritis.

Language: Английский

Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine DOI Creative Commons
Jiming Guo, Zhijie Huang, Qinjing Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 3, 2025

Language: Английский

Citations

6
Nanomaterial-enabled anti-biofilm strategies: new opportunities for treatment of bacterial infections DOI Creative Commons

Yijia Xie,

Huanhuan Liu, Zihao Teng

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biofilms play a pivotal role in bacterial pathogenicity and antibiotic resistance, representing major challenge the treatment of infections. The limited diffusion inactivation efficacy antibiotics within biofilms hinder their clearance, while increasing dosage may enhance effectiveness, it also promotes resistance. Nano-delivery systems that target antimicrobial agents directly to offer promising strategy overcome this challenge. This review summarizes resistance mechanisms therapeutic challenges associated with biofilms, focus on recent advances nano-delivery such as liposomes, nanoemulsions, cell membrane vesicles (CMVs), polymers, dendrimers, nanogels, inorganic nanoparticles, metal-organic frameworks (MOFs). Furthermore, explores potential applications biofilm provides recommendations guide future research development field.

Language: Английский

Citations

1
Bacteria extracellular vesicle as nanopharmaceuticals for versatile biomedical potential DOI Creative Commons
Ming Yao Ho, Songhan Liu, Bengang Xing

et al.

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: July 11, 2024

Abstract Bacteria extracellular vesicles (BEVs), characterized as the lipid bilayer membrane-surrounded nanoparticles filled with molecular cargo from parent cells, play fundamental roles in bacteria growth and pathogenesis, well facilitating essential interaction between host systems. Notably, benefiting their unique biological functions, BEVs hold great promise novel nanopharmaceuticals for diverse biomedical potential, attracting significant interest both industry academia. Typically, are evaluated promising drug delivery platforms, on account of intrinsic cell-targeting capability, ease versatile engineering, capability to penetrate physiological barriers. Moreover, attributing considerable immunogenicity, able interact immune system boost immunotherapy nanovaccine against a wide range diseases. Towards these directions, this review, we elucidate nature role activating response better understanding BEV-based nanopharmaceuticals’ development. Additionally, also systematically summarize recent advances achieving target genetic material, therapeutic agents, functional materials. Furthermore, vaccination strategies using carefully covered, illustrating flexible potential combating bacterial infections, viral cancer. Finally, current hurdles further outlook will be provided. Graphical

Language: Английский

Citations

7
A Sequential Therapeutic Strategy Based on Aptamer/Polymer‐Functionalized PDA/Ag for Precise Acinetobacter Baumannii Imaging and Pneumonia Treatment DOI
Yun Li, Zhen‐Chao Dong, Yingfei Ma

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Acinetobacter baumannii ( A. ) is a leading cause of pneumonia. Conventional antibiotics can increase the risk drug resistance and non‐specifically harm microflora, disrupting their balance. In addition to pathogenic bacteria, lung inflammation also damages tissue. This study develops an aptamer/polymer‐functionalized mesoporous polydopamine/silver nanocomposite (Apt/ODEA‐PDA/Ag‐ICG) specifically target sequentially exhibit antibacterial/antioxidative properties for pneumonia treatment. After synthesizing polyzwitterion (ODEA), polymer/aptamer conjugated with PDA/Ag core, ICG further labeled fabricate nanocomposite. Upon intratracheal instillation, nanocomposites penetrate mucus barrier help polyzwitterions. The precisely targets through specific recognition by aptamer, without affecting other microflora. Moreover, distributed disorderedly within polymer. near core contributes high NIR‐I absorbance good photothermal ability. from acts as fluorescent molecule imaging. Furthermore, efficiently exhibits synergistic antibacterial activity owing acidic environment/heat‐accelerated Ag + release effect. Importantly, alongside release, antioxidant ability PDA scavenges reactive oxygen species alleviates inflammation, thereby accelerating summary, provide alternative approach designing advanced systems.

Language: Английский

Citations

0
Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria DOI Creative Commons

Yujie Zhai,

Zhiqing Liang, Xijun Liu

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 708 - 708

Published: March 21, 2025

The rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development innovative therapeutic strategies overcome these challenges. Copper-based nanomaterials have emerged as promising agents due their intrinsic antibacterial properties, cost-effectiveness, and adaptability for multifunctional approaches. These materials exhibit exceptional potential in advanced therapies, including chemodynamic therapy (CDT), photothermal (PTT), photodynamic (PDT). Their unique physicochemical such controlled ion release, reactive oxygen species (ROS) generation, tunable catalytic activity, enable them target MDR effectively while minimizing off-target effects. This paper systematically reviews mechanisms through which Cu-based enhance efficiency emphasizes specific performance field. Key factors influencing properties—such electronic interactions, characteristics, size effects, ligand single-atom doping, geometric configurations—are analyzed depth. By uncovering copper-based nanomaterials, this work aims inspire approaches that improve patient outcomes, reduce burden bacterial infections, health initiatives.

Language: Английский

Citations

0
Recent Advances in Crystalline Porous Materials for Antibacterial Applications DOI

Peijie Wu,

Liangming Wei,

Rui Yao

et al.

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Bacterial infections remain a significant and escalating threat to global health, exacerbated by multidrug‐resistant strains that undermine the efficacy of conventional antibiotics. This pressing issue underscores urgent need for development new antimicrobial materials. Among these, molecular‐based crystalline porous materials, such as metal–organic frameworks (MOFs), covalent organic (COFs), hydrogen‐bonded (HOFs), supramolecular assembly (SAFs), have emerged promising class antibacterial agents. These materials exhibit well‐defined crystallinity tunable structures, offering exceptional versatility applications. Notably, their high surface area, adjustable pore size, potential functionalization enable efficient loading controlled release agents, including metal ions molecules. review provides comprehensive analysis recent advancements in this field, highlighting design strategies, structural diversity, mechanisms, Finally, we discuss current challenges outline future opportunities practical deployment

Language: Английский

Citations

0
Lubricating and Dual‐Responsive Injectable Hydrogels Formulated From ZIF‐8 Facilitate Osteoarthritis Treatment by Remodeling the Microenvironment DOI
Hongtao Zhang, Shiguo Yuan, Boyuan Zheng

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and proliferation bone, along with ongoing inflammation. Although precise pathogenesis remains somewhat elusive, restoring homeostatic balance intra‐articular microenvironment crucial for management OA. Intra‐articular injection medication one most direct effective treatment methods; however, injectable drugs used osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, frequent injections, leading increased risk infection suboptimal therapeutic outcomes. In this study, lubricating dual‐responsive hydrogel based on zeolitic imidazolate frameworks‐8 (ZIF‐8) impregnated Quercetin (Que) designed, which can facilitate OA remodeling microenvironment. The prepared nanocomposite (MH/CCM@ZIF‐8@Que) exhibits pH reactive oxygen species (ROS) responsiveness, alongside controllable release bioactive substances modulate bone tissue, thereby mitigating synovitis degeneration matrix, while simultaneously facilitating repair. This developed thermosensitive hydrogel, effectively balances lubrication controlled substances, represents highly promising approach osteoarthritis.

Language: Английский

Citations

1