The
immune
and
sensory
nervous
systems,
having
evolved
together,
use
a
shared
language
of
receptors
transmitters
to
maintain
homeostasis
by
responding
external
internal
disruptions.
Although
beneficial
in
many
cases,
neurons
can
exacerbate
inflammation
during
allergic
reactions,
such
as
asthma.
Our
research
modeled
asthma
aggravated
pollution,
exposing
mice
ambient
PM
2.5
particles
ovalbumin.
This
exposure
significantly
increased
bronchoalveolar
lavage
fluid
neutrophils
γδ
T
cells
compared
ovalbumin
alone.
We
normalized
airway
lung
neutrophil
levels
silencing
nociceptor
at
inflammation’s
peak
using
intranasal
QX-314
or
ablating
TRPV1-expressing
neurons.
Additionally,
we
observed
heightened
sensitivity
chemical-sensing
TRPA1
channels
from
pollution-exacerbated
asthmatic
mice.
Elevated
artemin
were
detected
the
pollution-exposed
mice,
with
normalizing
ablated
Upon
particles,
alveolar
macrophages
expressing
pollution-sensing
aryl
hydrocarbon
receptors,
identified
source
artemin.
molecule
enhanced
responsiveness
influx,
providing
novel
mechanism
which
lung-innervating
respond
air
pollution
suggesting
potential
therapeutic
target
for
controlling
neutrophilic
asthma,
clinically
intractable
condition.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(32)
Published: July 29, 2024
California
faces
several
serious
direct
and
indirect
climate
exposures
that
can
adversely
affect
public
health,
some
of
which
are
already
occurring.
The
health
burden
now
in
the
future
will
depend
on
atmospheric
greenhouse
gas
concentrations,
underlying
population
vulnerabilities,
adaptation
efforts.
Here,
we
present
a
structured
review
recent
literature
to
examine
leading
risks
California,
including
extreme
heat,
precipitation,
wildfires,
air
pollution,
infectious
diseases.
Comparisons
among
different
climate-health
pathways
difficult
due
inconsistencies
study
design
regarding
spatial
temporal
scales
outcomes
examined.
We
find,
however,
current
likely
affects
thousands
Californians
each
year,
depending
exposure
pathway
outcome.
Further,
while
more
evidence
exists
for
proximal
effects
focus
this
review,
distal
(e.g.,
impacts
drought
nutrition)
uncertain
but
could
add
burden.
find
measures
provide
significant
benefits,
particularly
disadvantaged
communities.
conclude
with
priority
recommendations
analyses
solution-driven
policy
actions.
American Journal of Perinatology Reports,
Journal Year:
2025,
Volume and Issue:
15(01), P. e18 - e24
Published: Jan. 1, 2025
Background
Wildfires
produce
air
pollutants
that
have
been
associated
with
complications
during
pregnancy.
This
study
examined
the
association
between
wildfire
exposure
before
and
pregnancy
odds
of
congenital
heart
defect
(CHD)
in
offspring.
Methods
retrospective
cohort
used
California
Linked
Birth
File
Forestry
Fire
Protection
data
2007
2010.
Patients
living
within
15
miles
were
considered
exposed.
Multivariate
logistic
regression
models
to
estimate
by
these
various
metrics
atrial
septal
(ASD)
or
ventricular
(VSD)
types
CHD
compared
pregnancies
without
exposure.
Results
Compared
births
exposure,
those
first-,
second-,
third-trimester
a
higher
risk
ASD
first-trimester
adjusted
ratio
(aOR)
1.11
(95%
confidence
interval
(CI):
1.04–1.18),
second-trimester
aOR
1.12
CI:
1.07–1.18),
1.08
1.02–1.14).
Wildfire
critical
window
fetal
development
(weeks
3–8)
was
1.02–1.23).
Conclusion
appears
increase
developing
ASD.
Key
points
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 26, 2025
Low-income
families
in
dry
regions,
including
the
Southwestern
United
States,
frequently
cool
their
homes
with
evaporative
("swamp")
coolers
(ECs).
While
inexpensive
and
energy
efficient
compared
to
central
air
conditioners,
ECs
pull
unfiltered
outdoor
into
home,
creating
a
health
hazard
occupants
when
wildfire
smoke
heat
events
coincide.
A
community-engaged
research
project
reduce
was
conducted
California's
San
Joaquin
Valley
of
Spanish-speaking
agricultural
workers.
total
88
study
participants
were
asked
about
level
satisfaction
EC
willingness
pay
for
filtration.
About
47%
reported
dissatisfaction
EC,
most
reason
being
that
it
brings
dust
pollution.
Participants
highly
satisfied
cleaners
filters
offered
them
free-of-charge.
However,
analysis
showed
filtration
solutions
would
not
be
adopted
without
significant
subsidies;
furthermore,
an
ongoing
cost
due
need
regularly
replace
filters.
Short-term
users
are
feasible
implement
may
exposure
during
events.
Such
at
low-or
no-cost
barriers
adoption.
Longer
term
include
prioritizing
exposed
regions
replacement
cooling
technologies
provide
clean
air.
Because
disproportionately
low-income
homes,
addressing
intrusion
through
these
devices
is
environmental
justice
issue.
Environment International,
Journal Year:
2025,
Volume and Issue:
199, P. 109513 - 109513
Published: May 1, 2025
Wildfire
events
in
the
US
are
becoming
more
frequent
and
intensive
due
to
climate
change.
Fire
smoke
can
significantly
contribute
ambient
PM2.5
(PM2.5,
particles
smaller
than
2.5
µm
diameter)
levels
alter
its
chemical
composition.
An
emerging
body
of
literature
has
linked
COPD
mortality
episodic
wildfire
exposure,
but
studies
on
effect
long-term
fire
exposure
is
lacking.
We
aimed
evaluate
how
affect
among
elderly
people
explore
spatial
variability
this
effect.
investigated
all
aged
65-100
years
contiguous
United
States
using
Medicare
National
Death
Index
data
from
2008
2016.
identified
three
subregions
based
risk
indicate
differences
exposure.
used
time-varying
Cox
Proportional
Hazards
Models
mortality.
found
that
strongly
associated
with
increase
1
µg/m3
was
a
9.2
%
(95
CI:
8.8
%-9.7
%).
Specifically,
A
may
deaths
by
40.4
%,
9.6
3.9
low,
moderate,
high
areas,
respectively.
Our
study
reveals
contributes
people.
Notably,
those
living
regions
relatively
lower
appear
vulnerable.
Therefore,
prevention
should
be
emphasized
areas
not
typically
active.
Atmosphere,
Journal Year:
2025,
Volume and Issue:
16(5), P. 582 - 582
Published: May 13, 2025
In
recent
years,
frequent
open
biomass
burning
(OBB)
activities
such
as
agricultural
residue
and
forest
fires
have
led
to
severe
air
pollution
carbon
emissions
across
South
Southeast
Asia
(SSEA).
We
selected
this
area
our
study
divided
it
into
two
sub-regions
based
on
climate
characteristics
geographical
location:
the
Asian
Subcontinent
(SEAS),
which
includes
India,
Laos,
Thailand,
Cambodia,
etc.,
Equatorial
(EQAS),
Indonesia,
Malaysia,
etc.
However,
existing
methods—primarily
emission
inventories
relying
burned
area,
fuel
load,
factors—often
lack
accuracy
temporal
resolution
for
capturing
fire
dynamics.
Therefore,
in
study,
we
employed
high-resolution
point
data
from
China’s
Feng
Yun-4A
(FY-4A)
geostationary
satellite
Fire
Radiative
Power
(FRP)
method
construct
a
daily
OBB
inventory
at
5
km
region
2020–2022.
The
results
show
that
average
annual
of
(C),
dioxide
(CO2),
monoxide
(CO),
methane
(CH4),
non-methane
organic
gases
(NMOGs),
hydrogen
(H2),
nitrogen
oxide
(NOX),
sulfur
(SO2),
fine
particulate
matter
(PM2.5),
total
(TPM),
(TPC),
(OC),
black
(BC),
ammonia
(NH3),
nitric
(NO),
(NO2),
hydrocarbons
(NMHCs),
≤
10
μm
(PM10)
are
178.39,
598.10,
33.11,
1.44,
4.77,
0.81,
1.02,
0.28,
3.47,
5.58,
2.29,
2.34,
0.24,
0.58,
0.43,
0.99,
1.87,
3.84
Tg/a,
respectively.
Taking
C
an
example,
90%
SSEA’s
come
SEAS,
especially
concentrated
Laos
western
Thailand.
Due
La
Niña
anomaly
2021,
surged,
while
EQAS
showed
continuous
growth
16.7%.
Forest
woodland
were
dominant
sources,
accounting
over
85%
emissions.
Compared
with
datasets
Global
Emissions
Database
(GFED)
Assimilation
System
(GFAS),
FY-4A
stronger
sensitivity
regional
adaptability,
SEAS.
This
work
provides
robust
dataset
source
identification,
quality
modeling,
control
strategies.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(20)
Published: May 14, 2025
Wildfires
have
become
more
frequent
and
severe,
evidence
showed
that
exposure
to
wildfire-caused
PM
2.5
(fire-PM
)
is
associated
with
adverse
health
effects.
Fire-PM
occurs
mainly
indoors,
where
people
spend
most
of
their
time.
As
an
effective
timely
approach
mitigating
indoor
pollution,
air
purifiers
incur
notable
costs.
However,
the
long-term
global
population
fire-PM
economic
burden
using
remain
unknown.
Here,
we
estimated
concentration
cost
reducing
exposure,
along
extra
incurred
because
,
at
a
resolution
0.5°
by
globally
during
2003
2022.
Our
findings
revealed
1009
million
individuals
exposed
least
one
substantial
wildfire-air
pollution
day
per
year.
We
identified
pronounced
socioeconomic
disparities
in
costs
low-income
countries
bearing
disproportionately
higher
burden,
emphasizing
critical
need
for
addressing
these
disparities.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(20)
Published: May 14, 2025
Using
air
purifiers
to
reduce
indoor
exposure
wildfire-related
PM
2.5
is
effective
but
costly,
placing
a
disproportionately
higher
financial
burden
on
low-income
countries.
International Journal of Climatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 15, 2025
ABSTRACT
Warming
and
drying
meteorological
conditions
associated
with
anthropogenic
climate
change
have
increased
the
risk
of
extreme
heat
wildfire
in
many
regions
around
world.
Extreme
smoke
fine
particulate
matter
(smoke
PM
2.5
)
individually
contribute
to
substantial
global
morbidity
mortality
burdens,
while
emerging
evidence
suggests
that
co‐occurring
events
mayssssssssss
synergistic
impacts
exacerbate
adverse
health
outcomes.
Despite
potential
for
a
high
societal
burden,
these
are
an
underexplored
climate‐related
hazard.
To
quantify
co‐occurrence
smoke,
we
combined
daily
estimates
index
(a
combination
temperature
relative
humidity)
over
western
United
States
document
spatiotemporal
patterns
frequency,
duration
intensity
individual
from
2006
2020.
We
found
130
million
person‐days
exposure
exceedances
15‐year
study
period.
These
were
most
often
late
summer
when
temporal
distributions
typically
coincide,
spatially
northern
California
Montana
where
overlap.
best
our
knowledge,
this
presents
largest
database
population‐level
events.
also
show
specific
definitions
can
substantially
affect
both
number
spatial
distribution
events,
implications
future
epidemiological
or
studies.