Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Open Access
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

Published: Sept. 24, 2024

When retrieved, seemingly stable memories can become sensitive to modification through significant events, such as acute stress. While memory dynamics after retrieval have profound implications, for instance, in eyewitness testimony or aberrant mental disorders, the mechanisms underlying these remain poorly understood. Here, we show healthy humans that increases noradrenaline impairs subsequent remembering, depending on hippocampal and cortical reactivation during retrieval. In a three-day fMRI study, measured brain activity initial encoding (Day 1), 24h-delayed cueing accompanied by administration of placebo, hydrocortisone, α2-adrenoceptor antagonist yohimbine 2), final recall, 24h later 3). post-retrieval hydrocortisone did not affect (i.e., recall), impairing effect recall depended strength category-level reinstatement ventral temporal cortex Day 2 Notably, was contingent specifically neural patterns from online were also reinstated rest-period, this offline interact with pharmacological manipulation. Additionally, original trace significantly reactivated rest, further supporting critical dependency manipulations signal emerging retrieval-related reactivation. Our findings demonstrate that, memories, noradrenergic arousal alter future accessibility consolidated memories.

Language: Английский

Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Creative Commons
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood. Here, we show that noradrenergic stimulation after retrieval impairs subsequent remembering, depending on hippocampal and cortical signals emerging during retrieval. In a three-day study, measured brain activity using fMRI initial encoding, 24 hr-delayed cueing followed by pharmacological elevations of glucocorticoid or activity, final recall. While post-retrieval glucocorticoids did not affect memory, the impairing effect arousal recall depended reactivation category-level reinstatement in ventral temporal cortex cueing. These effects require original trace interact with offline rest. Our findings demonstrate that, retrieval-related neural memories, alter future accessibility consolidated memories.

Language: Английский

Citations

0
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Open Access
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

Published: Jan. 9, 2025

When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood. Here we show that noradrenergic stimulation after retrieval impairs subsequent remembering, depending on hippocampal and cortical signals emerging during retrieval. In a three-day study, measured brain activity using fMRI initial encoding, 24h-delayed cueing followed by pharmacological elevations of glucocorticoid or activity, final recall. While post-retrieval glucocorticoids did not affect memory, the impairing effect arousal recall depended reactivation category-level reinstatement in ventral temporal cortex cueing. These effects require original trace interact with offline rest. Our findings demonstrate that, retrieval-related neural memories, alter future accessibility consolidated memories.

Language: Английский

Citations

0
Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents DOI
Chad A. Brunswick,

Chelsea Carpenter,

Nancy A. Dennis

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106195 - 106195

Published: May 1, 2025

Language: Английский

Citations

0
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Creative Commons
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Abstract When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood. Here we show that noradrenergic stimulation after retrieval impairs subsequent remembering, depending on hippocampal and cortical signals emerging during retrieval. In a three-day study, measured brain activity using fMRI initial encoding, 24h-delayed cueing followed by pharmacological elevations of glucocorticoid or activity, final recall. While post-retrieval glucocorticoids did not affect memory, the impairing effect arousal recall depended reactivation category-level reinstatement in ventral temporal cortex cueing. These effects require original trace interact with offline rest. Our findings demonstrate that, retrieval-related neural memories, alter future accessibility consolidated memories.

Language: Английский

Citations

0
Long COVID patients’ brain activation is suppressed during walking and severer symptoms lead to stronger suppression DOI

Gengbin Chen,

Quan Liu,

Jialin Chen

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Language: Английский

Citations

0
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Open Access
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

Published: Sept. 24, 2024

When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood. Here, we show that noradrenergic stimulation after retrieval impairs subsequent remembering, depending on hippocampal and cortical signals emerging during retrieval. In a three-day study, measured brain activity using fMRI initial encoding, 24 hr-delayed cueing followed by pharmacological elevations of glucocorticoid or activity, final recall. While post-retrieval glucocorticoids did not affect memory, the impairing effect arousal recall depended reactivation category-level reinstatement in ventral temporal cortex cueing. These effects require original trace interact with offline rest. Our findings demonstrate that, retrieval-related neural memories, alter future accessibility consolidated memories.

Language: Английский

Citations

0
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation DOI Open Access
Hendrik Heinbockel, Gregor Leicht, Anthony D. Wagner

et al.

Published: Sept. 24, 2024

When retrieved, seemingly stable memories can become sensitive to modification through significant events, such as acute stress. While memory dynamics after retrieval have profound implications, for instance, in eyewitness testimony or aberrant mental disorders, the mechanisms underlying these remain poorly understood. Here, we show healthy humans that increases noradrenaline impairs subsequent remembering, depending on hippocampal and cortical reactivation during retrieval. In a three-day fMRI study, measured brain activity initial encoding (Day 1), 24h-delayed cueing accompanied by administration of placebo, hydrocortisone, α2-adrenoceptor antagonist yohimbine 2), final recall, 24h later 3). post-retrieval hydrocortisone did not affect (i.e., recall), impairing effect recall depended strength category-level reinstatement ventral temporal cortex Day 2 Notably, was contingent specifically neural patterns from online were also reinstated rest-period, this offline interact with pharmacological manipulation. Additionally, original trace significantly reactivated rest, further supporting critical dependency manipulations signal emerging retrieval-related reactivation. Our findings demonstrate that, memories, noradrenergic arousal alter future accessibility consolidated memories.

Language: Английский

Citations

0