Mitochondrial proteostasis in axons: key roles for neuronal health DOI Creative Commons
Marta Zaninello, Elena I. Rugarli

BIOspektrum, Journal Year: 2024, Volume and Issue: 30(6), P. 631 - 633

Published: Oct. 1, 2024

Abstract Neurons integrate perception, motor, and cognitive functions, relying heavily on mitochondria for ATP production to support axonal transport, synaptic activity, maintenance of membrane potential. Mitochondrial dysfunction disrupts energy supply, increases oxidative stress, impairs calcium buffering, contributing degeneration in neurodegenerative diseases. Mitochondria are strategically located transported within highly polarised neurons, posing the problem maintaining functional organelles dendritic regions far away from cell body. This article highlights mechanisms that ensure quality mitochondrial proteome neurons.

Language: Английский

RNA-binding proteins as versatile metabolic regulators DOI Creative Commons

Ellie Koletsou,

Ina Huppertz

npj Metabolic Health and Disease, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 13, 2025

Abstract Metabolic shifts are a hallmark of numerous biological processes, including the differentiation stem cells along specific lineage and activation diverse cell types, such as immune cells. This review examines intricate energy metabolic alterations that occur in settings, from embryonic development to adult tissue homoeostasis disease states. In particular, we emphasise regulatory function RNA-binding proteins (RBPs) coordinating these examine how they modulate key pathways, glycolysis oxidative phosphorylation, meet dynamic cellular demands. highlights various mechanisms by which RBPs regulate changes, ranging active involvement post-transcriptional regulation metabolically relevant genes alteration an RBP’s RNAs, metabolites or growth factors. Finally, consider ageing affect can disrupt delicate balance regulation. Taken together, this provides comprehensive overview critical interplay between metabolism offers insights into potential therapeutic targets for regenerative medicine age-related diseases.

Language: Английский

Citations

0
Multi-organelle-mediated mRNA localization in neurons and links to disease DOI Creative Commons

Vance K. Bauer,

Max Koppers

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 92, P. 102332 - 102332

Published: March 7, 2025

Brain function requires precise spatiotemporal regulation of the neuronal proteome. To allow adaptation proteome in distal outposts neurons, mRNAs are transported into neurites for localized translation. This mRNA localization and local translation is crucial neuron maintenance, dysregulation these processes can contribute to neurological disease. Recently, organelles have emerged as key players regulating dendrites axons. In this review, we discuss current evidence open questions organelle-mediated localization. We highlight an emerging model which multiple create orchestrate a subcellular microenvironment that support selective seems essential maintaining organellar health, mutations many involved proteins lead various disorders.

Language: Английский

Citations

0
The role of mitochondrial mRNA translation in cellular communication DOI Creative Commons
Eleonora Zilio, Tim Schlegel, Marta Zaninello

et al.

Journal of Cell Science, Journal Year: 2025, Volume and Issue: 138(9)

Published: May 1, 2025

ABSTRACT Mitochondria are dynamic and heterogeneous organelles that rewire their network metabolic functions in response to changing cellular needs. To this end, mitochondria integrate a plethora of incoming signals influence cell fate survival. A crucial highly regulated node cell–mitochondria communication is the translation nuclear-encoded mitochondrial mRNAs. By controlling monitoring spatio-temporal these mRNAs, cells can rapidly adjust function meet demands, optimise ATP production regulate organelle biogenesis turnover. In Review, we focus on how RNA-binding proteins recognise mRNAs acutely modulate rate nutrient availability. We further discuss relevance localised for subsets polarised cells. Finally, highlight quality control mechanisms monitor process at surface connections mitophagy stress responses. propose processes collectively contribute specialisation signalling function.

Language: Английский

Citations

0
Mitochondrial Dynamics and mRNA Translation: A Local Synaptic Tale DOI Creative Commons
Marta Zaninello, Pedro Baptista, Filipe V. Duarte

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(9), P. 746 - 746

Published: Sept. 23, 2024

Mitochondria are dynamic organelles that can adjust and respond to different stimuli within a cell. This plastic ability allows them effectively coordinate several cellular functions in cells becomes particularly relevant highly complex such as neurons. An imbalance mitochondrial dynamics disrupt function, leading abnormal function ultimately range of diseases, including neurodegenerative disorders. Regulation mRNA transport local translation inside neurons is crucial for maintaining the proteome distal mitochondria, which vital energy production synaptic function. A significant portion axonal transcriptome dedicated mRNAs proteins, emphasizing importance sustaining areas far from cell body. In neurons, regulation encoding mitochondrial-shaping proteins could be essential plasticity neuronal health. The these mRNAs, their translation, may influence morphology thereby affecting overall status responsiveness synapses. Comprehending mitochondria-related well its on near synapses will help better understand physiology neurological diseases where dysfunction impaired play central role.

Language: Английский

Citations

2
Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions DOI Creative Commons
Leonor Miller‐Fleming, Wing Hei Au,

Laura Raik

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

ABSTRACT Mitochondria perform essential metabolic functions and respond rapidly to changes in stress conditions. As the majority of mitochondrial proteins are nuclear-encoded, intricate post-transcriptional regulation is crucial enable mitochondria adapt changing cellular demands. The eukaryotic Clustered protein family has emerged as an important regulator function during shifts. Here, we show that Drosophila melanogaster Saccharomyces cerevisiae Clu/Clu1 form dynamic, membraneless granules adjacent response changes. Yeast Clu1 regulates translation a subset nuclear-encoded by interacting with their mRNAs while these engaged translation. We further polysomes, independently whether it diffuse or granular state. Our results demonstrate remarkable functional conservation other members suggests isolate concentrate ribosomes translating mRNA targets, thus, integrating signals synthesis.

Language: Английский

Citations

0
Mitochondrial proteostasis in axons: key roles for neuronal health DOI Creative Commons
Marta Zaninello, Elena I. Rugarli

BIOspektrum, Journal Year: 2024, Volume and Issue: 30(6), P. 631 - 633

Published: Oct. 1, 2024

Abstract Neurons integrate perception, motor, and cognitive functions, relying heavily on mitochondria for ATP production to support axonal transport, synaptic activity, maintenance of membrane potential. Mitochondrial dysfunction disrupts energy supply, increases oxidative stress, impairs calcium buffering, contributing degeneration in neurodegenerative diseases. Mitochondria are strategically located transported within highly polarised neurons, posing the problem maintaining functional organelles dendritic regions far away from cell body. This article highlights mechanisms that ensure quality mitochondrial proteome neurons.

Language: Английский

Citations

0