Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

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Implantable physical sensors for in vivo organ monitoring

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 8, 2025

Abstract Implantable sensors can provide access to accurate, continuous, and minimally invasive monitoring of physiological signals from internal organs tissues, thereby facilitating timely diagnosis, closed-loop intervention, advanced health management. Among the various types implantable sensors, those capable measuring physical parameters–such as temperature, force, flow–are particularly important due their ability monitor conditions critical nearly all insights into a wide range conditions. This review presents recent progress in four key sensors: strain pressure temperature flow sensors. It covers engineering principles, design considerations, vivo performances, clinical relevance. The also addresses challenges future opportunities development such flexibility stretchability, biocompatibility, long-term stability, translation these sensing technologies bench clinic. Graphical

Language: Английский

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Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract The healing of bacterial biofilm‐infected wounds is a complex process, and the construction emerging therapeutic modalities that regulate microenvironment to magnify effects reduce biotoxicity still highly challenging. Herein, an engineered microneedle (MN) patch reported mediate efficient delivery black phosphorus nanosheets (BP NSs) copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization methicillin‐resistant staphylococcus aureus (MRSA)‐infected wound healing. Results demonstrate system can eliminate biofilm, cytotoxicity, promote angiogenesis tissue regeneration by multiple advantages chemodynamic therapy (CDT), enhanced photodynamic (PDT), improved degradation process from BP NSs phosphate promoting cell proliferation. Notably, balance between excellent stability rapid degradability maintained, mechanism vividly elucidated density functional theory (DFT)‐based molecular dynamics (MD) calculations. Furthermore, transcriptional changes treated MRSA‐infected skin are studied using RNA‐seq technology reveal potential mechanism. As envisaged, proposed MN provides safe, easy, also effective approach achieve temporal regulation wounds.

Language: Английский

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Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording

Microsystems & Nanoengineering, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 23, 2025

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Language: Английский

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Advancements in Flexible Electrode Implantation for Invasive Brain-Computer Interfaces

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 125, P. 55 - 65

Published: Feb. 18, 2025

In recent years, with the development of flexible electronic devices and advances in material science, electrodes have played an important role field invasive brain-computer interface (BCI). Compared traditional rigid electrodes, implanted brain cause less damage to tissue are more biocompatible stable. Most made glass or metal, which prone damage, inflammation, other problems, although they can avoid interference from skull skin record neural signals accurately low noise. However, main materials for polymers, hydrogels, graphene, etc., reduce immune rejection prolong service life implants. This paper describes five implantation methods years: microneedle arrays, coiled implantation, minimally injections, biodegradable stretchable electronics implantation. They be used most appropriate way different structures acquire stable reliable fidelity. Flexible potential a wide range applications neuromonitoring providing safer durable solution interfaces. Then authors will propose new idea combining their respective advantages hope bringing enlightenment.

Language: Английский

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Microneedle electrodes: materials, fabrication methods, and electrophysiological signal monitoring-narrative review

Biomedical Microdevices, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 25, 2025

Language: Английский

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A Facile Strain Visualization Method for Stretchable Serpentine Interconnects

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Evaluating the stretchability of stretchable interconnects is crucial for ensuring stable operation in practical applications electronics. Conventional methods often involve destructive testing and lack comprehensive strain distribution data. Digital image correlation (DIC) can provide clear visualization, but its application to serpentine electrodes, which generally deform out‐of‐plane direction, remains challenging. With growing interest in‐plane stretching this study proposes possibility resolve problems conventional approaches using DIC thick electrodes. Herein, a facile method analysis presented by utilizing simple speckle patterning optical microscopy. Using method, various electrode designs bonded soft substrate under extension be experimentally visualized. Furthermore, accumulation plastic at positions on investigated. The proposed offers new way evaluating has profound implications development future

Language: Английский

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Highly Stable Polymeric Electrooculography Electrodes for Contactless Human-Machine Interactions

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Capturing the electrooculography (EOG) signals is very attractive for assistive devices and user interfaces virtual reality (VR) systems. However, current EOG acquisition systems face challenges in ensuring comfort, particularly terms of electrode electrical mechanical performance, long-term usability, thermal effects, overall system portability. This study presents polymeric dry flexible electrodes, composed a composite poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS), poly(vinyl alcohol) (PVA), Gallic acid (GA), D-sorbitol, forming dynamic cross-linked network that ensures strong adhesion, stretchability, stability. These electrodes maintain their performance up to 72 h, can be restored through heat reactivation if degrades after prolonged storage. exhibits excellent biocompatibility, causing no skin irritation or effects with continuous use. We have also developed circuit real-time signal processing wireless transmission, which operates coordination electrodes. The employs convolutional neural (CNN) achieve 97.1% accuracy classifying various eye movement patterns. enables contactless control digital simple movements, offering solution long-term, comfortable, high-fidelity EOG-based human-machine interfaces, VR integration technologies individuals disabilities.

Language: Английский

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先进激光用于图形化加工基底的技术与应用

Laser & Optoelectronics Progress, Journal Year: 2025, Volume and Issue: 62(7), P. 0700005 - 0700005

Published: Jan. 1, 2025

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Engineering sampling microneedles for biomolecules sensing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130

Published: Sept. 1, 2024

Language: Английский

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